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Double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, preparation method and application of compound system

A combination therapy and dual-targeting technology, applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., to improve treatment efficiency, synergistic high-efficiency photothermal treatment ability, and high drug-loading capacity Effect

Active Publication Date: 2018-10-30
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the fact that the current design of cancer treatment systems based on composite materials has not been reported to use folic acid and supramolecular nano-valve assisted polypyrrole-MOFs composite materials to prepare dual-target mediated chemotherapy-photothermal therapy combined therapy for cancer, the present invention actively Through research and innovation, a high-efficiency combined cancer compound system was finally prepared to expand the organic combination of supramolecular chemistry, material science, and medical materials, and to develop a new direction for the development and utilization of high-efficiency anti-cancer compound systems in the future.

Method used

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  • Double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, preparation method and application of compound system
  • Double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, preparation method and application of compound system
  • Double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, preparation method and application of compound system

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of Polypyrrole Nanoparticles (PPy NPs)

[0045] Add ferric chloride hexahydrate (1.3g) to an aqueous solution (20mL) of polyvinyl alcohol (1.5g) and stir at 500rpm for 2.5h, and then add pyrrole monomer (150μL, 0.1mol / L) to continue stirring under the same conditions for 5h, centrifuge (13000rpm, 30min), and wash with water for 5 times to obtain PPy NPs, which were then redispersed in 20mL DMF for use. The concentration is 30mg / mL.

Embodiment 2

[0047] Preparation of PPy-MOFs hybrid materials

[0048] Get PPy NPs solution 1mL among the embodiment 1, zirconium tetrachloride (23.15mg) and 2-aminoterephthalic acid (18.16mg) are dissolved in DMF (4mL) to obtain MOFs precursor solution, PPy NPs solution and MOFs The precursor solutions were mixed, and the resulting mixture was transferred to a pressure-resistant tube at 100°C for 12 h of reaction. After the reaction was completed, the sample was cooled to room temperature, centrifuged, washed with DMF and ethanol three times, and dried to obtain the PPy-MOFs material (PU NPs), the mass is 40mg.

Embodiment 3

[0050] Preparation of Linker Molecule 1-(6-Bromohexane)pyridine Bromide (Py)

[0051] Add 5 mL of 1,6-bromohexane to 50 mL of CH 2 Cl 2 0.5 mL of pyridine was slowly added dropwise to the above mixture, refluxed at 70°C for 36 h, cooled, distilled under reduced pressure, and dried to obtain Py molecule with a mass of 500 mg.

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Abstract

The invention discloses a folic acid recognition and pillararene nano-valve controlled-release double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, a preparationmethod and application of the compound system, and belongs to the technical field of compound medical materials. The preparation method includes that polypyrrole nanoparticles (PPy NPs) are used as anuclear matrix, a metal organic frame material (MOFs) reaction mother solution directly reacts with the nuclear matrix by means of in-situ growth to form a PPy-MOFs compound nanomaterial, and 'connecting shaft' molecules are modified on the PPy-MOFs compound nanomaterial by means of post-modification for subsequent mounting of a pillararene nano-valve mediated by subject-object acting force; polyethyleneimine polymer (PEI-Fa) modified by folic acid is post-modified on a compound material equipped with a supermolecule nano-valve. Design of the whole compound material therapy system brings synergism of all parts into full play, organic combination of chemotherapy and photothermal therapy is realized, and targeted and controlled drug release is realized through controllability of the nano-valve and folic acid recognition.

Description

technical field [0001] The invention belongs to the technical field of composite medical materials, and specifically relates to a dual-targeting mediated chemotherapy-photothermal combination therapy cancer composite system for folic acid recognition and pillar aromatic hydrocarbon nano-valve controlled release, a preparation method for post-synthesis modification and its application. The present invention realizes targeted recognition of cancer cells, targeted controllable drug release at lesion sites, photothermal therapy, and chemotherapy for efficient treatment of cervical cancer, which is beneficial to improving disease treatment efficiency. Background technique [0002] Cervical cancer is one of the major diseases that threaten human health. With the continuous improvement of medical requirements and the development of medical materials, people are paying more and more attention to the design and preparation of multifunctional and efficient composite material treatment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/513A61K47/34A61P35/00
CPCA61K31/513A61K41/0052A61K47/34A61P35/00A61K2300/00
Inventor 杨英威武明雪
Owner JILIN UNIV
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