Method for preparing gold nanometer spherical shells with polydopamine as template

A technology of polydopamine and nanospheres, which is applied in the field of materials, can solve the problems of nanomaterials such as environmental pollution, complex process, and high mechanical strength, and achieve the effects of simple molecular composition, simple preparation process, and low cost

Inactive Publication Date: 2018-10-02
YANSHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned traditional preparation methods generally have disadvantages such as high cost, high mechanical strength, complicated process, and long time

Method used

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  • Method for preparing gold nanometer spherical shells with polydopamine as template
  • Method for preparing gold nanometer spherical shells with polydopamine as template
  • Method for preparing gold nanometer spherical shells with polydopamine as template

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Take 5 mg of dopamine hydrochloride (produced by Shanghai Aladdin Biochemical Technology Co., Ltd.), and dissolve it in 10 mL of Tris hydrochloric acid buffer solution with pH 8.5 to obtain a dopamine hydrochloride solution with a concentration of 0.5 mg / mL; place the configured solution on a magnetic stirrer Stir for 1 hour at 25°C in the dark; then use an ultrasonic cell pulverizer to sonicate for 10 minutes with an ultrasonic power of 500 W. After ultrasonication, centrifuge at 8,000 rpm for 10 minutes to take the supernatant, and centrifuge the supernatant at 14,000 rpm to get the precipitate. , after the precipitate was washed once by centrifugation with deionized water, 0.35 mg of the precipitate was resuspended in 5 mL of pH 2 hydrochloric acid solution; 200 μL of the above solution was added to 200 μL of a gold chloride solution with a concentration of 2 mM and pH 2 (Shanghai West Asia Reagent Co., Ltd.), mix it evenly, put it into a double-layer air bath shaker,...

Embodiment 2

[0026] Take 7.5 mg of dopamine hydrochloride (produced by Shanghai Aladdin Biochemical Technology Co., Ltd.), dissolve it in 15 mL of Tris hydrochloric acid buffer solution with pH 8.5, and obtain a concentration of 0.5 mg / mL dopamine hydrochloride solution; place the above solution in a magnetic stirrer Stir for 1.5 hours at a temperature of 20°C in the dark; then use an ultrasonic cell pulverizer to sonicate for 10 minutes, with an ultrasonic power of 500W, and centrifuge at 8,000rpm for 10 minutes to take the supernatant, and centrifuge the supernatant at 14,000rpm to take the precipitate After the precipitate was centrifuged and washed twice with deionized water, 0.525 mg of the precipitate was resuspended in 7.5 mL of pH 2 hydrochloric acid solution; 200 μL of the above polydopamine solution was added to 200 μL of gold chloride with a concentration of 4 mM and pH 2 Solution (Shanghai West Asia Reagent Co., Ltd.), mix well, put it into a double-layer air bath shaker, contro...

Embodiment 3

[0032] Take 10 mg of dopamine hydrochloride (produced by Shanghai Aladdin Biochemical Technology Co., Ltd.), dissolve it in 20 mL of Tris hydrochloric acid buffer solution with pH 8.5, and obtain a concentration of 0.5 mg / mL dopamine hydrochloride solution; place the above solution on a magnetic stirrer , stirred at 15°C for 2 hours in the dark; then sonicated with an ultrasonic cell pulverizer for 10 minutes, with an ultrasonic power of 500 W, and centrifuged at 8,000 rpm for 10 minutes to take the supernatant, and then centrifuged the supernatant at 14,000 rpm to get the precipitate. After the precipitate was washed by centrifugation with deionized water for 3 times, 0.7 mg of the precipitate was resuspended in 10 mL of pH 2 hydrochloric acid solution; 200 μL of the above polydopamine solution was added to 200 μL of gold chloride solution with a concentration of 6 mM and pH 2 (Shanghai West Asia Reagent Co., Ltd.), mix well, then put it into a double-layer air bath shaker, co...

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Abstract

The invention discloses a method for preparing gold nanometer spherical shells with polydopamine as a template. Tris hydrochloric acid buffer liquid with pH of 8.5 is mainly used as solvent for preparing dopamine hydrochloride solution with a concentration of 0.5 mg/mL; the dopamine hydrochloride solution is ultrasonically treated after sunshade magnetic stirring under the condition of 15-25 DEG C; then, supernate is taken after centrifugation, and is centrifuged to take precipitates; after the precipitates are centrifugally cleaned by de-ionized water, the precipitates are suspended in hydrochloric acid solution with pH of 2 to prepare polydopamine solution; the polydopamine solution is added in isovolumetric gold chloride solution, and is put in an oscillator for incubation by 0.5-1.5 hat 25 DEG C under 100-200 rpm; ascorbic acid solution with a concentration of 20-60 mM is added in the incubated solution for reduction; the reaction temperature is 15-25 DEG C; the reaction time is 5-10 min; and the gold nanometer spherical shells with uniform particle sizes and excellent monodispersity are prepared. The method has the advantages of mild reaction conditions, simple preparation process, high yield, small particle sizes, excellent monodispersity, excellent photothermal conversion performance and the like.

Description

technical field [0001] The invention belongs to the technical field of materials, in particular to a method for preparing metal nanomaterials. Background technique [0002] Nanoparticles refer to ultrafine particles whose particle size is at the nanometer level. They are in the transition zone between atomic clusters and macroscopic objects, between microscopic and macroscopic. Due to the ultramicrostructure, nanomaterials have four unique effects: small size effect, quantum tunnel effect, surface and interface effect and quantum size effect. Among many nanomaterials, gold nanomaterials are widely used in the research of electrocatalysts, cell detectors, biosensors, and photothermal therapeutic agents for tumors due to their unique electrical, optical, biological, and other related properties. Among them, gold nanospheres have excellent optical properties, and their surface plasmon resonance peaks can undergo a large red shift, which can be used for photothermal therapy of ...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00
CPCB22F9/24B82Y40/00
Inventor 高大威牛康刘欢杨梦雪
Owner YANSHAN UNIV
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