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Mussaenda pubescens extractive and preparation and application in treating enteritis thereof

A technology of jasmine leaves and extracts is applied in the directions of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., to achieve the effects of short course of treatment, good therapeutic effect and remarkable effect.

Inactive Publication Date: 2018-09-28
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the study of adding the extract of Jade Leaf Golden Flower to the traditional Chinese medicine composition for the treatment of enteritis has not been reported yet.

Method used

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  • Mussaenda pubescens extractive and preparation and application in treating enteritis thereof
  • Mussaenda pubescens extractive and preparation and application in treating enteritis thereof
  • Mussaenda pubescens extractive and preparation and application in treating enteritis thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 Jade leaf golden flower extract

[0028] Follow the steps below:

[0029] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 60-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0030] (2) According to the ratio of Yuye Jinhua powder and isopropanol aqueous solution at a ratio of 1:20, reflux extraction at the azeotropic point of 88-92°C for 30 minutes, filter, concentrate under reduced pressure, and collect fractions;

[0031] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:10, soak at 35°C for 30 minutes, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2000MHz, microwave The power is 400W, the extraction time is 5min, the liquid is separated, the organic phase is collected, and the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure to obtain the extract of Jade Leaf Golde...

Embodiment 2

[0032] The preparation of embodiment 2 Jade leaf golden flower extract

[0033] Follow the steps below:

[0034] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing an 80-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0035] (2) According to the ratio of Yuye Jinhua powder and isopropanol aqueous solution of 1:30, reflux extraction at the azeotropic point of 88-92°C for 100 minutes, filter, concentrate under reduced pressure, and collect fractions;

[0036] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:20, warm soak at 37°C for 60 minutes, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2370MHz, microwave The power is 500W, the extraction time is 7min, the liquid is separated, the organic phase is collected, the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure, and the extract of Jade Leaf Golden Flower is o...

Embodiment 3

[0037] The preparation of embodiment 3 Jade leaf golden flower extract

[0038] Follow the steps below:

[0039] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 100-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0040] (2) According to the ratio of Yuyejinhua powder and isopropanol aqueous solution at a ratio of 1:50, reflux extraction at the azeotropic point of 88-92°C for 180 minutes, filter, concentrate under reduced pressure, and collect fractions;

[0041] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:30, soak at 40°C for 90 minutes, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2700MHz, microwave The power is 600W, the extraction time is 10min, the liquid is separated, the organic phase is collected, and the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure to obtain the extract of Jade Leaf Gol...

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Abstract

The invention provides a mussaenda pubescens extractive and a preparation method and application in treating enteritis thereof. The preparation method comprises the following steps that the mussaendapubescens is dried and crushed to obtain the mussaenda pubescens powder; the mussaenda pubescens powder is mixed with isopropanol aqueous solution, refluxing, filtering and concentrating are carried out, and fraction is collected; and pure water is added into the fraction, warm soaking is carried out, microwave extraction with ethyl acetate-butyl acetate is carried out, liquid separating is carried out, organic phase is collected , rotary evaporation is used for removing the solvent, and the mussaenda pubescens extractive is obtained. Astragalus membranaceus, plantago asiatica, radix paeoniaealba , codonopsis pilosula, dried alum, areca-nut, poria cocos, rhizoma Coptidis, sanguisorba officinalis, glutinous rice root, cumin, nutmeg and clove are crushed and mixed, then decocted, filtered and concentrated to obtain composition water extract, the diluted mussaenda pubescens extractive is added into the composition water extract, and solid powder is obtained by mist spraying and drying. The mussaenda pubescens extractive has obvious effect for treating the enteritis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine extraction, in particular to the extract of Jade Leaf Golden Flower and its preparation, especially to the application of the extract in the treatment of enteritis Background technique [0002] Gastroenteritis is an inflammation of the stomach and intestinal lining that is caused by food poisoning. Gastroenteritis is a common and frequently-occurring disease in summer and autumn. Mostly due to bacterial and viral infections. The main manifestations are upper gastrointestinal symptoms and varying degrees of diarrhea and abdominal discomfort, followed by loss of electrolytes and fluids, which belong to the category of "vomiting, abdominal pain, and diarrhea" in traditional Chinese medicine. The treatment of gastroenteritis with traditional Chinese medicine is a traditional medical treatment method in the motherland, which has a long history. Through continuous improvement and ...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K36/899A61P1/00A61K33/06
CPCA61K36/74A61K33/06A61K36/076A61K36/185A61K36/235A61K36/344A61K36/481A61K36/61A61K36/65A61K36/68A61K36/71A61K36/718A61K36/739A61K36/889A61K36/899A61K2236/331A61K2236/333A61K2236/55A61K2300/00
Inventor 赵立春张谦华
Owner GUANGXI UNIV OF CHINESE MEDICINE
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