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An encapsulation bi 2 the s 3 Nanoparticle alginate microspheres and preparation method thereof

A technology of alginate and nanoparticles, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of cumbersome preparation process and harsh preparation conditions of nanoparticles, and achieve simple preparation process, controllable particle size of microspheres, Versatile Effects

Active Publication Date: 2020-06-19
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation process is cumbersome, and the preparation conditions of nanoparticles are generally relatively harsh, requiring solvents, high temperatures, reaction kettles, etc.

Method used

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  • An encapsulation bi <sub>2</sub> the s <sub>3</sub> Nanoparticle alginate microspheres and preparation method thereof
  • An encapsulation bi <sub>2</sub> the s <sub>3</sub> Nanoparticle alginate microspheres and preparation method thereof
  • An encapsulation bi <sub>2</sub> the s <sub>3</sub> Nanoparticle alginate microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] This embodiment provides a kind of encapsulation Bi 2 S 3 The preparation method of the alginate microsphere of nanoparticle, its flow chart is as figure 1 shown, including the following steps:

[0053] (1) Preparation of oil phase (continuous phase): weigh 0.008g anhydrous CaCl 2 Add it into 4mL ethanol, ultrasonically dissolve or stir to dissolve, then add it into 10mL liquid paraffin containing 2.0wt% Span80, stir for 3 hours to mix, and then magnetically stir in a 60°C water bath to completely volatilize the ethanol until the solution changes from turbid to For clarification, after cooling to room temperature, the oil phase containing calcium salt nanoparticles formed in situ is obtained;

[0054] (2) Preparation of water phase (dispersed phase): first prepare 2.0wt% sodium alginate aqueous solution, then add Na 2 S 2 o 3 , so that Na 2 S 2 o 3 The concentration is 0.15mol / L, which is the water phase;

[0055] (3) Preparation of Bi 3+ and Ca 2+ Acid rece...

Embodiment 2

[0061] This embodiment provides a kind of encapsulation Bi 2 S 3 The preparation method of the alginate microsphere of nanoparticle, comprises the following steps:

[0062] (1) Preparation of oil phase: weigh anhydrous CaCl 2 Dissolve in absolute ethanol, ultrasonically dissolve or stir to dissolve, then add to silicone oil containing 1.0wt% Span 80, stir and mix well, then magnetically stir in a 60°C water bath to completely evaporate the ethanol until the solution changes from turbid to clear , after cooling to room temperature, the oil phase can be obtained;

[0063] (2) Preparation of water phase: first prepare 1.5wt% sodium alginate aqueous solution, then add Na 2 S, make Na 2 When the S concentration is 0.1mol / L, the aqueous phase is obtained;

[0064] (3) Preparation of Bi 3+ and Ca 2+ Acidic receiving solution: Weigh a certain amount of BiCl 3 and CaCl 2 Dissolved in 10wt% dilute sulfuric acid to make Bi 3+ and Ca 2+ The final concentration of each is 0.1mol...

Embodiment 3

[0068] This embodiment provides a kind of encapsulation Bi 2 S 3 The preparation method of the alginate microsphere of nanoparticle, comprises the following steps:

[0069] (1) preparation oil phase: with embodiment 1;

[0070] (2) Prepare the water phase: first prepare 5.0wt% sodium alginate aqueous solution, then add thiourea, the final concentration of thiourea is 0.5mol / L, and stir to obtain the water phase;

[0071] (3) Preparation of Bi 3+ and Ca 2+ Acidic receiving solution: Weigh a certain amount of BiCl 3 and Ca(NO 3 ) 2 Dissolved in 20wt% dilute nitric acid to make Bi 3+ and Ca 2+ The final concentration of is 0.5mol / L and 3.0mol / L respectively, then add Tween20 and Oπ-10, make both final concentrations be 5.0wt / V%;

[0072] (4) Preparation of microspheres by microfluidic method: use a T-shaped microfluidic chip, set the flow rate of the oil phase to 6000 μL / h, and the flow rate of the water phase to 2000 μL / h to form droplets with uniform particle size, and...

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Abstract

The invention provides an alginate microsphere encapsulating Bi2S3 nanoparticles and a preparation method thereof. The preparation method comprises the following steps: using a liquid-drop-type microfluidic technology, using sodium alginate aqueous solution containing a soluble sulfocompound as a dispersion phase, using an oil phase containing a surfactant as a continuous phase, forming a liquid drop in a microfluidic chip, importing the liquid drop into the aqueous solution containing Bi3<+> along with the continuous phase, and placing until a reaction is completed. The preparation method isbased on the liquid-drop-type microfluidic technology, and a sulfur source is provided by the sulfocompound in the dispersion phase. While the continuous phase is encountered in a microchannel, the dispersion phase is cut to the uniform liquid drops, and the liquid drops are imported to reception liquid containing the Bi3<+>, the in-situ formed alginate microsphere encapsulating Bi2S3 nanoparticles is obtained by one step. The process is simple, a particle diameter of the microsphere is controllable, and the obtained microsphere can be used as an intervention material. The microsphere has thefunctions of thermal therapy, embolism, CT imaging and sensibilization chemotherapy.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an encapsulating Bi 2 S 3 Nanoparticle alginate microspheres and methods for their preparation. Background technique [0002] Transcatheter arterial chemoembolization (TACE) is the first choice for non-surgical treatment of advanced liver cancer (C.D.Gadaleta, et al. Crit Rev Oncol Hematol, 2011, 80(1): 40-53). The embolic material is selectively delivered to the blood vessels of the tumor. On the one hand, it kills tumor cells through local high-concentration cytotoxic drugs; TACE combines the two treatment methods of transarterial embolization and local chemotherapy, and has the advantages of small wound, low side effects and high curative effect. However, there are still some shortcomings in the TACE treatment of liver cancer, such as incomplete tumor necrosis, which requires repeated treatment (J.Y. Huang, et al. FertilSteril, 2006, 85(1): 30-35; E.J. Dorenberg, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K41/00A61K47/36A61K49/04A61P35/00A61L24/08A61L24/00B82Y5/00
CPCA61K9/5036A61K41/0052A61K49/04A61L24/0015A61L24/08A61L2300/10A61L2300/622A61L2430/36A61P35/00B82Y5/00C08L5/04
Inventor 王芹邹倩杨亚江杨祥良廖永贵王宏
Owner HUAZHONG UNIV OF SCI & TECH
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