Quinoline compound and preparation method and application thereof to prevention of plant diseases
A technology for plant diseases and compounds, which is applied in the fields of botanical equipment and methods, chemical instruments and methods, compounds of elements of Group 4/14 of the periodic table, etc., and can solve problems such as the application of inhibiting agricultural pathogens that have not been reported in literature.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0010] Synthesis of Quinoline Derivatives (KL-1)
[0011] method one:
[0012]
[0013] Method Two:
[0014]
[0015] Its concrete synthetic operation is as follows:
[0016] Method 1: Add 0.247 g of the raw material 2,8-bistrifluoromethylquinoline into a 50 mL single-necked bottle, dissolve it with 20 mL of acetone, first add equimolar potassium carbonate, then add equimolar benzyl chloroformate, and heat to reflux for 3 hours , filtered to obtain the filtrate, evaporated the solvent, and purified the developer by column chromatography (ethyl acetate:petroleum ether=1:5) to obtain a white solid.
[0017] Method 2: Add 0.247 g of the raw material 2,8-bistrifluoromethylquinoline into a 50 mL single-necked bottle, add 5 mL of acetic anhydride, heat and reflux for 3 hours, follow the completion of the reaction by plate chromatography, and evaporate excess acetic anhydride under reduced pressure , separated by plate chromatography (developing solvent: ethyl acetate: petro...
Embodiment 2
[0020] Synthesis of KL-2: the experimental procedure is the same as in Example 1, except that acetyl chloride is replaced by propionyl chloride.
[0021]
[0022] KL-2 white solid, yield 83%; 1 H NMR (400MHz, Chloroform-d) δ8.15 (dd, J = 14.6, 7.9Hz, 2H), 7.74 (s, 1H), 7.67 (s, 1H), 2.77 (d, J = 7.5Hz, 2H) ,1.32(t,J=7.6Hz,3H).ESI-MS m / z:360.08[M+Na] + .
Embodiment 3
[0024] Synthesis of KL-3: the experimental procedure is the same as in Example 1, except that acetyl chloride is replaced by chloroacetyl chloride.
[0025]
[0026] KL-3 white solid, yield 72%; 1 H NMR (400MHz, Chloroform-d) δ8.19 (dd, J=20.8, 7.9Hz, 2H), 7.79(s, 1H), 7.72(t, J=7.9Hz, 1H), 4.43(s, 2H) .ESI-MS m / z:380.02[M+Na] + .
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com