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Gelatin microsphere/magnesium phosphate-based bone cement medicine slow-release carrier and preparation method thereof

A magnesium phosphate-based bone, slow-release carrier technology, used in pharmaceutical formulations, drug delivery, prostheses, etc., can solve the problems of insignificant long-term sustained-release effect, fast drug release, and inability to achieve sustained-release, to promote potential Ability, promote bone repair, maintain activity effect

Active Publication Date: 2018-08-10
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of drug loading has obvious shortcomings: the drug is directly mixed with the bone cement powder phase or liquid phase to prepare the drug-loaded bone cement, and there may be mutual adverse effects between the bone cement and the drug during the hydration process; If the cured bone cement is loaded with drugs, the drug will be released too fast to achieve the effect of sustained release
At present, although some studies have introduced drug-loaded microspheres into bone cement, the long-term sustained release effect is not obvious
The Chinese patent with publication number 101564556A discloses a composite drug-loading system of gelatin microspheres and calcium phosphate bone cement, but its drug release rate is relatively fast, and the drug release amount exceeds 90% within 14 days
[0004] Bone defects, especially those caused by bone diseases such as osteomyelitis, bone tumors, bone tuberculosis, etc., often require continuous drug treatment for several months to achieve complete healing, and the drug release is too fast to meet the demand

Method used

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  • Gelatin microsphere/magnesium phosphate-based bone cement medicine slow-release carrier and preparation method thereof
  • Gelatin microsphere/magnesium phosphate-based bone cement medicine slow-release carrier and preparation method thereof
  • Gelatin microsphere/magnesium phosphate-based bone cement medicine slow-release carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 1.5 g of gelatin microspheres and 0.03 g of diclofenac sodium and dissolve them in distilled water at 50° C. to prepare a uniformly mixed pharmaceutical gelatin aqueous solution. Take another 30mL of liquid paraffin and 3mL of Span 80 in a round bottom flask, stir for 10min at a speed of 500r / min and a temperature of 50°C, then slowly add the drug gelatin solution dropwise into the flask at a speed of 250r / min, and stir After 10 minutes, quickly use an ice-water bath, and after 15 minutes, add 1 mL of carbodiimide hydrochloride solution with a concentration of 0.5 mol / L. Continue stirring and cross-linking for 60 minutes, take it out, wash with isopropanol, and dry at room temperature to obtain gelatin microspheres loaded with diclofenac sodium. The morphology of the microspheres was observed with a scanning electron microscope, such as figure 2 shown.

[0035]The bone cement powder is prepared by uniformly mixing magnesium oxide, potassium dihydrogen phosphate...

Embodiment 2

[0038] Weigh 1.5 g of gelatin microspheres and 0.03 g of diclofenac sodium and dissolve them in distilled water at 50° C. to prepare a uniformly mixed pharmaceutical gelatin aqueous solution. Take another 30mL of liquid paraffin and 3mL of Span 80 in a round bottom flask, stir for 10min at a speed of 500r / min and a temperature of 50°C, then slowly add the drug gelatin solution dropwise into the flask at a speed of 350r / min, and stir After 10 minutes, quickly use an ice-water bath, and after 15 minutes, add 1 mL of carbodiimide hydrochloride solution with a concentration of 1 mol / L. Continue stirring and cross-linking for 60 minutes, take it out, wash with isopropanol, and dry at room temperature to obtain gelatin microspheres loaded with diclofenac sodium. The part where the gelatin microspheres and bone cement are combined is the same as in Example 1.

[0039] The drug-loaded gelatin microsphere has good sphere-forming effect, and the particle size is 0-250 μm. The strength...

Embodiment 3

[0041] Weigh 1.5 g of gelatin microspheres and 0.03 g of diclofenac sodium and dissolve them in distilled water at 50° C. to prepare a uniformly mixed pharmaceutical gelatin aqueous solution. Take another 30mL of liquid paraffin and 3mL of Span 80 in a round bottom flask, stir for 10min at a speed of 500r / min and a temperature of 50°C, then slowly add the drug gelatin solution dropwise into the flask at a speed of 350r / min, and stir After 10 minutes, quickly use an ice-water bath, and after 15 minutes, add 1 mL of carbodiimide hydrochloride solution with a concentration of 0.1 mol / L. Continue stirring and cross-linking for 60 minutes, take it out, wash with isopropanol, and dry at room temperature to obtain gelatin microspheres loaded with diclofenac sodium. The part where the gelatin microspheres and bone cement are combined is the same as in Example 1.

[0042] The drug-loaded gelatin microsphere has good sphere-forming effect, and the particle size is 0-250 μm. The streng...

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Abstract

The invention discloses a gelatin microsphere / magnesium phosphate-based bone cement medicine slow-release carrier and a preparation method thereof. Firstly, medicine carried gelatin microspheres crosslinked by 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride are prepared; then, the medicine carried gelatin microspheres are uniformly mixed with magnesium phosphate-based bone cement powderand are then subjected to liquid phase conditioning curing with the magnesium phosphate-based bone cement to obtain the gelatin microsphere / magnesium phosphate-based bone cement medicine slow-releasecarrier. The 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride is used as a gelatin crosslinking agent; the obtained gelatin microsphere has good compatibility; the gelatin microspheres can carry various kinds of medicine; the degradation speed of the microspheres can be controlled through the concentration of the crosslinking agents; the medicine release speed is further controlled; the gelatin microsphere / magnesium phosphate-based bone cement medicine slow-release carrier has the excellent medicine slow release effect, and realizes the continuous release of medicine as long as several months.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a bone filling and repairing material with drug therapeutic effect and a method for preparing the material. Background technique [0002] In modern society, population aging, production, traffic accidents, and diseases such as bone tuberculosis, osteomyelitis, and bone tumors have caused a large number of patients who need bone tissue defect repair. Traditional bone tissue defect repair is mainly achieved by autologous bone grafting and allogeneic bone grafting. But both methods have different degrees of defects. The former is a method of "curing wounds with wounds"; the latter often brings problems such as disease transmission and immune rejection, and the sources of both are limited. However, the sources of artificial materials are not limited, and many researchers have paid attention to them and conducted a lot of research on them, and developed a ...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/22A61L27/54A61L27/58
CPCA61L27/222A61L27/425A61L27/54A61L27/58A61L2300/412A61L2300/604A61L2300/622
Inventor 戴红莲余素春王浩赵雅楠
Owner WUHAN UNIV OF TECH
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