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Intelligent spectrum system for detection of biomolecules

A technology of intelligent spectrum and target molecules, applied in bioinformatics, sequence analysis, instruments, etc., can solve the problems of lengthy and cumbersome detection process, difficult to meet individual needs, etc.

Active Publication Date: 2022-04-01
BIOYONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the relevance of these test data and related fields, technical personnel in this field (such as doctors, inspection and quarantine personnel, etc.) are required to make comprehensive judgments based on professional knowledge and combined with other information. Only personnel (such as experimenters and doctors) can complete the detection and related improvement, which is difficult to solve the contradiction between the current growing individual needs and the lengthy and cumbersome detection process and insufficient manpower

Method used

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  • Intelligent spectrum system for detection of biomolecules
  • Intelligent spectrum system for detection of biomolecules
  • Intelligent spectrum system for detection of biomolecules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1: Preparation of an intelligent mass spectrometry system

[0070] The intelligent mass spectrometry system includes a mass spectrometer data acquisition system 1, an intelligent fuzzy expert system 2, a knowledge base acquisition system 3, a model acquisition system 4 and a human-computer interaction system 5, wherein,

[0071] The mass spectrometer data acquisition system 1 includes a mass spectrometer device 101, a mass spectrometer data management device 102, and a mass spectrometry database storage device 103 for samples. The mass spectrometer device 101 is respectively connected with the mass spectrometer data management device 102, the mass spectrometer database storage device 103 and the user interface 501, and sends The mass spectrometry data of the object to be tested, the data management device 102 also accepts the detection result mass spectrometry model sent by the decision model building device 203, and transmits the final result represented by the ...

Embodiment 2

[0076] Example 2: Detection of caries characteristic protein by intelligent spectrum method

[0077] (1) Establishment of a mass spectrometry model of caries characteristic proteins by intellectual spectroscopy

[0078] 1. Samples and instruments:

[0079] Selected from 29 saliva samples, of which 14 were from caries patients and the other 15 were from healthy people. All caries patients were confirmed by pathology reports. All saliva samples were taken on an empty stomach in the morning before eating, and the saliva was separated and stored in a -80 low temperature freezer.

[0080] Matrix-assisted laser desorption time-of-flight mass spectrometry MALTI TOF MS was selected, and the WCX magnetic bead kit used in the experiment was developed by the applicant Bioyong Company. The data analysis software Bioexplorer of Bioyong Company was used for data preprocessing, and the processed data were processed by the genetic algorithm package genalg of the statistical analysis softwar...

Embodiment 3

[0107] Example 3: Diagnosis of early esophageal cancer by intellectual spectrum method

[0108] (1) Establishment of mass spectrometry model of characteristic proteins of early esophageal cancer by intellectual spectroscopy

[0109] 1. Samples and Instruments

[0110] Selected from 62 serum samples, of which 28 were from patients with esophageal cancer, and the other 34 were from healthy people. All patients with esophageal cancer were identified by pathology reports. All serum samples were taken on an empty stomach in the morning before eating, and the serum was separated and stored in a -80 low temperature freezer.

[0111] The matrix-assisted laser desorption time-of-flight mass spectrometry CLIN-TOF and the weak cation exchange magnetic bead kit for experiments were developed by Beijing Bioyong Company (the applicant). The data analysis software Bioexplorer of Bioyong Company was used for data preprocessing, and the processed data were processed by the genetic algorithm ...

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Abstract

The invention provides an intelligent spectrum system for detecting target molecules, comprising: a mass spectrometer data acquisition system, an intelligent fuzzy expert system, a knowledge base acquisition system and a model acquisition system. Among them, the mass spectrometer data acquisition system is used to detect the mass spectrum data of the sample; the intelligent fuzzy expert system can intelligently analyze the mass spectrum data; the knowledge base acquisition system can pre-store and manage the relevant knowledge related to mass spectrometry detection through the cloud center; the model acquisition system The known mass spectrum model data can be sent to the knowledge management system and the mass spectrum model storage device according to the instruction. The present invention is supported by cloud center computing, through the intelligent learning and storage of the knowledge base collection system, intelligently analyzes the mass spectrum data through the intelligent fuzzy expert system, and can simulate and generate a large amount of training data at a low cost, which is beneficial to the analysis Large samples, suitable for non-professional operations, real-time monitoring of personal health information, to meet the needs of personalized medical services.

Description

technical field [0001] The invention relates to an intelligent mass spectrometry system for detecting biomolecules, which combines traditional mass spectrometry with artificial intelligence. It belongs to the technical field of instrument manufacturing. Background technique [0002] For decades, researchers have carried out in-depth research on mass spectrometry in terms of high resolution and high sensitivity. At present, the resolution and sensitivity of mass spectrometry have been greatly improved and have basically reached the limit of physics. Mass spectrometry, which uses electric and magnetic fields to move ions (charged atoms, molecules, or molecular fragments, including molecular ions, isotopic ions, fragment ions, rearranged ions, multiply charged ions, metastable ions, negative ions, and ion-molecules) The ions generated by the interaction) are separated according to their mass-to-charge ratios and detected, and the compound composition of the ions can be determi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B30/10G16B50/00
CPCG16B30/00G16B50/00
Inventor 马庆伟薛恒钢白春雨张荣陈莲莲安娜战晓薇
Owner BIOYONG TECH
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