A kind of medical nanofiber reinforced hydrophilic composite material and its preparation method and application

Abstract

The invention discloses a medical nanofiber-reinforced hydrophilic composite material and its preparation method and application. The composite material is composed of a hydrophilic base material and nano-short fibers, and the nano-short fibers maintain a crystalline form and are uniformly dispersed on the hydrophilic base. In the material, the mass percentage of the nano-short fiber in the composite material is 1%~30%; the diameter of the nano-short fiber is 200~800nm, and the length is 10~100 μm; the preparation method of the medical nanofiber reinforced composite material of the present invention, The process design is unique, using the solubility difference between the base material and nano-short fibers to evenly disperse the nano-short fibers in the base material, and use the freeze-drying method to obtain a porous sponge-like composite material, which maintains the respective advantages of the two materials. Complementing the disadvantages, a composite material with excellent mechanical properties, good biocompatibility, and good biodegradability is obtained. Its degradation cycle is moderate, and it will not cause postoperative inflammation and postoperative risk of adhesion, which is more suitable for clinical needs. .

Description

technical field [0001] The invention relates to the technical field of nanofiber composite materials, in particular to a medical nanofiber-reinforced hydrophilic composite material and its preparation method and application. Background technique [0002] Various tissues and organs in the human body may be abnormal or damaged. At present, the transplantation of tissues and organs is mainly used to restore their functions. In this process, a large amount of biological materials are needed to support the normal work of tissues and organs, such as stents, Ligation clips, etc., materials with good biocompatibility and biodegradability can finally form new functional tissues with the further proliferation and differentiation of cells and the degradation and absorption of materials to achieve the purpose of repairing defective tissues. The demand in the market is also increasing. [0003] Medical materials prepared from single-component polymer raw materials have high elongation a...

AI Technical Summary

Problems solved by technology

[0003] Medical materials prepared from single-component polymer raw materials have high elongation at break, good flexibility, and little damage to blood vessels and other tissues, but they also have the following shortcomings, such as slow degradation speed, poor tensile strength, and falling off. It takes 1 to 2 months, and it takes more than 6 months for complete absorption. In clinical practice, the closure time of blood vessels and other tubular tissues is only 1 to 2 weeks. There are potential risks in the long-term use of medical materials in the human body. In addition, blood vessels or other tissues may still Phenomena such as damage and bleeding are not conducive to the recovery of patients; while simple grafting or copolymerization of two materials is used, the composition ratio, segment distribution, molecular weight, etc. are not easy to control stably, and the mechanical properties and biodegradability of the material are very low. It is difficult to meet the requirements at the same time, so it cannot fully meet the clinical needs of medical polymer materials

[0004] Natural bioabsorbable polymer materials, such as collagen, gelatin, hyaluronic acid, chitosan, etc., have good hydrophilicity, biocompatibility, and biodegradability. Compared with synthetic materials, they have cell signal recognition. It can promote cell adhesion, proliferation and differentiation, and can be used for tissue regeneration and repair materials. However, this type of material also has the following disadvantages. The mechanical properties are low, especially after contact with water, the strength will further decrease or deform. In clinical application When the product is broken, it may fall off and other undesirable phenomena, which limits the application of this type of material

Images