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Method for preparing poly N,N-dimethylacrylamide-b-polyglycidyl methacrylate block copolymer

A technology of dimethylacrylamide and polymethacrylic acid, applied in the field of chemical engineering, can solve the problems of large differences in solubility and hydrophilic/lipophilic properties, and achieve the effects of easy separation, easy composition and simple composition

Inactive Publication Date: 2018-07-17
JIANGSU LISIDE NEW MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large difference in the solubility and hydrophilic / lipophilic properties of GMA and DMAA monomers and their homopolymers, the method for preparing PDMAA-b-PGMA block copolymers by living radical polymerization has not been disclosed or reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0011] Add 1L of water / tetrahydrofuran mixture with a volume ratio of 1 / 1, 100g of N,N-dimethylacrylamide monomer and 5.0g of iodoform into the reactor, close the reactor and exclude oxygen, raise the temperature to 35°C, and add 10.0 1g sodium dithionite and 2.0g sodium bicarbonate were stirred and polymerized for 6 hours; n-hexane was added to the above reaction solution to precipitate the aqueous phase containing the polymer, separated and vacuum-dried at room temperature to obtain 84.7g iodine-terminated active polyN, N-dimethylacrylamide has a theoretical number average molecular weight of 6670 and a number average molecular weight of 6050 as measured by gel chromatography.

[0012]Dissolve 10g of active poly-N,N-dimethylacrylamide in 100mL of water / tetrahydrofuran mixture with a volume ratio of 1 / 1, add 2.5g of glycidyl methacrylate, and place in a sealed reactor that excludes oxygen , then add 0.25g sodium dithionite and 0.05g sodium bicarbonate, polymerize at 35°C for ...

Embodiment 2

[0014] Add 1L of water / tetrahydrofuran mixture with a volume ratio of 1 / 1, 100g of N,N-dimethylacrylamide monomer and 5.0g of iodoform into the reactor, close the reactor and exclude oxygen, raise the temperature to 35°C, and add 10.0 1g sodium dithionite and 2.0g sodium bicarbonate were stirred and polymerized for 6 hours; n-hexane was added to the above reaction solution to precipitate the aqueous phase containing the polymer, separated and vacuum-dried at room temperature to obtain 84.7g iodine-terminated active polyN, N-dimethylacrylamide has a theoretical number average molecular weight of 6670 and a number average molecular weight of 6050 as measured by gel chromatography.

[0015] Dissolve 10g of active poly N,N-dimethylacrylamide in 100mL of water / tetrahydrofuran mixture with a volume ratio of 1 / 1, add 0.5g of glycidyl methacrylate, and place in a sealed reactor that excludes oxygen , then add 0.1g sodium dithionite and 0.02g sodium bicarbonate, polymerize at 35°C for ...

Embodiment 3

[0017] Add 1L of water / tetrahydrofuran mixture with a volume ratio of 1 / 1, 100g of N,N-dimethylacrylamide monomer and 5.0g of iodoform into the reactor, close the reactor and exclude oxygen, raise the temperature to 35°C, and add 10.0 1g sodium dithionite and 2.0g sodium bicarbonate were stirred and polymerized for 6 hours; n-hexane was added to the above reaction solution to precipitate the aqueous phase containing the polymer, separated and vacuum-dried at room temperature to obtain 84.7g iodine-terminated active polyN, N-dimethylacrylamide has a theoretical number average molecular weight of 6670 and a number average molecular weight of 6050 as measured by gel chromatography.

[0018] Dissolve 10g of active poly-N,N-dimethylacrylamide in 100mL of water / tetrahydrofuran mixture with a volume ratio of 1 / 1, add 5.0g of glycidyl methacrylate, and place in a sealed reactor that excludes oxygen , then add 0.5g sodium dithionite and 0.1g sodium bicarbonate, polymerize at 35°C for 8...

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PUM

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Abstract

The invention discloses a method for preparing a poly N,N-dimethylacrylamide-b-polyglycidyl methacrylate block copolymer with a water / tetrahydrofuran mixed solvent as a reaction medium through singleelectron transfer living free radical polymerization. N,N-dimethylacrylamide monomers, iodoform, sodium dithionite and sodium bicarbonate are added into the water / tetrahydrofuran mixed solvent, and polymerization and separation are conducted to obtain iodine-terminated active poly N,N-dimethylacrylamide; the purified active poly N,N-dimethylacrylamide is dissolved in the water / tetrahydrofuran mixed solvent, glycidyl methacrylate, sodium dithionite and sodium bicarbonate are added, and polymerization and separation are conducted to obtain the poly N,N-dimethylacrylamide-b-polyglycidyl methacrylate block copolymer. The method has the advantages of short process route, easy regulation of product composition, simple separation and the like. The obtained poly N,N-dimethylacrylamide-b-polyglycidyl methacrylate block copolymer can be used for surface lubrication modification of metal and plastic medical instruments (catheters and the like), and the like.

Description

technical field [0001] The invention relates to the technical field of chemical engineering, in particular to a preparation method of poly-N,N-dimethylacrylamide-b-polyglycidyl methacrylate block copolymer. Background technique [0002] In order to reduce tissue damage such as blood vessels, reduce the pain of the operated person and improve the operability of the operator, it is required that medical devices such as catheters inserted into the living body should have excellent lubricity. A method of lubricating hydrophilic polymers. Catheters are mostly made of metal and plastic materials, which have poor binding force with pure hydrophilic polymers. Hydrophilic polymers are easy to dissolve and peel off from the surface of the substrate, which affects the use effect and safety. In order to improve the bonding fastness between hydrophilic polymers and catheter substrates, Japanese Patent Application Publication No. 8-33704 discloses a solution in which a water-soluble or w...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/32C08F6/12
CPCC08F6/12C08F220/32C08F220/325C08F293/005C08F2438/01C08L53/00
Inventor 李金忠
Owner JIANGSU LISIDE NEW MATERIAL
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