Application of hydroxyethyl starch in making wound dressing

Abstract

The invention discloses an application of hydroxyethyl starch to preparation of a wound dressing. The wound dressing is prepared from hydroxyethyl starch and a dressing carrier, wherein the hydroxyethyl starch is a product prepared by substituting corn starch containing a branch-chain with ethoxy, wherein the molecular weight is 10,000Da to 70,000Da. The wound dressing prepared with the hydroxyethyl starch has larger specific surface area, high porosity, and can be used for absorbing seepage on the wound; wound dressing can be combined through a coordination bond after absorbing water to builda network-staggered structure with extremely high crosslink degree, so that high viscosity and flexibility are achieved; a moist and micro-acid environment can be provided, local sterilizing performance is enhanced, anti-bacteria effect is durable, infection rate is lowered, the dosage of the antibiotic is lowered, the healing of the wound is facilitated, postoperative tissue adhesion is avoided;the hydroxyethyl starch has high biocompatibility, can be degraded effectively in a living body, is wide in application range, is low in production cost, and can be used for lowering medical cost.

Description

Technical field [0001] The present invention relates to the technical field of sanitary materials, and more specifically to the application of hydroxyethyl starch in making wound dressings. Background technique [0002] Clinically, wound repair refers to a series of pathophysiological processes in which the wound tissue is regenerated, repaired, and rebuilt after tissue loss due to the action of the injury factor. In the process of wound repair, it is necessary to care for the wound. In the process of wound healing, wound infection, wound bleeding, and fluid effusion will affect the healing of the wound. Long-term difficult to heal wounds may even cause life-threatening. [0003] At present, the widely used wound dressings mainly include fiber wound dressings, polymer membrane wound dressings, foam polymer wound dressings, hydrocolloid wound dressings and hydrogel dressings. [0004] 1. Fibrous wound dressings can quickly absorb wound exudate, and the production and processing proce...

AI Technical Summary

Problems solved by technology

However, during the dissolution process of alginate, there will be a "fish eye" phenomenon, and the surface of the particles will swell with water to form a colloidal layer. At this time, the molecular chains have not formed random coils that can move freely. The formation delays and hinders the penetration of water molecules into the gel, and then the particles are cemented into a block, forming a large mass with an initial gel on the surface and a dry core inside. The wound dressing cannot quickly absorb the water and blood on the wound surface. , exudate and other liquids, and thus cannot form a colloidal protective layer, and cannot effectively protect the wound surface

[0010] In view of the above-mentioned problems of wound dressings, and the current wound dressings are mainly suitable for the protection of external wounds, wounds, etc., few wound dressings can be applied to internal wounds. The wound surface formed during the operation process absorbs liquids such as blood and exudate to form a colloidal protective layer to prevent infection, reduce the application of antibiotics, promote wound healing and prevent postoperative tissue adhesion, which has urgent clinical significance

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