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Drug-loaded artificial bone material for repairing bone defect and preparation method thereof

A technology for artificial bone and bone defect, applied in the field of orthopedic materials, can solve the problems of unsatisfactory slow release effect of growth factors and easy degradation, achieve good biocompatibility and bone conduction ability, promote repair growth, and repair bone defects Effect

Active Publication Date: 2018-06-22
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, with the continuous advancement of tissue engineering technology, the construction of tissue-inductive bone repair materials has become a research hotspot. However, the use of bone growth-related factors to construct tissue-inducible bone repair materials has unsatisfactory slow-release effects of growth factors and is prone to Degradation and other deficiencies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]Preparation of amino-modified icariin: Add 1mL tetrahydrofuran and 0.5mL pyridine into 200mL double-distilled water and stir well, then add 1mmoL icariin and stir until completely dissolved, then add 1mmoL tert-butyloxycarbonylglycine tert-butyl ester, After rapid stirring for 1.5 h, slowly add 1 mL of tetrahydrofuran solution containing 1.5 wt % dicyclohexylcarbodiimide and 0.5 wt % dimethylaminopyridine dropwise, stir for 24 h, add double distilled water, suction filter, double distilled water Wash the filter residue, remove insolubles as much as possible, concentrate the solution by rotary evaporation, and then precipitate the concentrated solution in water, then add a tetrahydrofuran solution containing 1.5wt% dicyclohexylcarbodiimide and 0.5wt% dimethylaminopyridine , freeze overnight, remove the insoluble matter, concentrate, add double distilled water to precipitate the precipitate, and repeat this operation four times to obtain the product of the dehydration conde...

Embodiment 2

[0036] The preparation of amino-modified icariin is the same as in Example 1.

[0037] Preparation of modified chitosan: soak 1g of chitosan in absolute ethanol for 2 to 3 days, wash with distilled water, dry in vacuum, grind the obtained chitosan powder and dissolve in 100mL of 2% acetic acid solution , followed by adding 0.30 g of polyethylene glycol, stirring for 1.5 h, and vacuum drying to obtain modified chitosan.

[0038] Preparation of modified loofah: take loofah and put it into deionized water to boil for 5 minutes, take it out and dry it, then transfer it to a plasma reactor, and perform plasma treatment for 10 minutes under the regulation of oxygen flow rate 90sccm, pressure 4Pa, and power 110W to obtain loofah Loofah fiber, dry the loofah fiber again until the water content is 4%, grind it into powder, take the loofah powder and add it to the calcium liquid activator to soak for 7 hours, stir for 5 minutes every 1 hour during soaking, filter, wash, vacuum at 50-55°...

Embodiment 3

[0043] The preparation of amino-modified icariin is the same as in Example 1.

[0044] Preparation of modified chitosan: soak 1g of chitosan in absolute ethanol for 2 to 3 days, wash with distilled water, dry in vacuum, grind the obtained chitosan powder and dissolve in 100mL of 2% acetic acid solution , followed by adding 0.30 g of polyethylene glycol, stirring for 1.5 h, and vacuum drying to obtain modified chitosan.

[0045] Preparation of modified loofah: take loofah and put it into deionized water to boil for 5 minutes, take it out and dry it, then transfer it to a plasma reactor, and conduct plasma treatment for 9 minutes under the regulation of oxygen flow rate 85sccm, pressure 4Pa, and power 115W to obtain loofah Loofah fiber, dry the loofah fiber again until the water content is 4%, grind it into powder, take the loofah powder and add it to the calcium liquid activator to soak for 7.5h, stir for 5min every 1h during soaking, filter and wash, 50~55℃ Vacuum drying to o...

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PUM

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Abstract

The invention relates to the technical field of orthopedic materials, and particularly relates to a drug-loaded artificial bone material for repairing a bone defect and a preparation method thereof. The drug-loaded artificial bone material is prepared from the following raw materials in parts by weight: 5 to 10 parts of drug-loading microsphere, 60 to 70 parts of compound gel particle, 10 to 16 parts of diphase calcium phosphate powder and 2.5 to 4 parts of collagen, wherein the drug-loading microsphere is a complex of hyaluronic acid and modified icariin; the modified icariin is amino modified icariin; the compound gel particle is a complex of modified chitosan and modified retinervus luffae fructus; the mass ratio of the modified chitosan to the modified retinervus luffae fructus is (1 to 2) to 1. According to the drug-loaded artificial bone material provided by the invention, the amino modified icariin for promoting the secretion of the alkaline phosphatase of osteoblast and promoting the skeletal calcification and bone formation is mixed with the hyaluronic acid; the drug property of the drug-loaded artificial bone material is slowly released; the repairing and the growth of defective bone tissue are continuously promoted; in addition, the bacteriostatic and antipyrotic effects are achieved through the modified chitosan, and besides, the artificial bone material is good indegradability and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of orthopedic materials, in particular to a drug-loaded artificial bone material for repairing bone defects and a preparation method thereof. Background technique [0002] Bone is an important tissue and organ in the human body that undertakes life activities. According to incomplete statistics, more than 3 million people suffer from various orthopedic diseases every year due to accident trauma, tumors and human congenital defects. Bone is the second most demanded graft after blood. Bone defect is a very common clinical trauma, and the bone repair process is very long, mainly including the hematoma and inflammation phase, the initial callus reaction phase, the cartilage formation phase, and the bone formation and remodeling phase. In the process of bone repair, cells secrete a variety of growth factors to play a role in different timing to ensure the repair of bone defects. [0003] Clinically, when a bone...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/24A61L27/20A61L27/12A61L27/18A61L27/54A61L27/58A61K38/39A61K9/16A61P19/08A61K31/7048A61K31/728A61K31/722A61K36/42
CPCA61K31/7048A61K31/722A61K31/728A61K36/42A61K38/39A61L27/12A61L27/18A61L27/20A61L27/24A61L27/3604A61L27/3637A61L27/54A61L27/58A61L2300/236A61L2300/252A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/602A61L2430/02C08L5/08C08L71/02C08L67/04A61K2300/00
Inventor 马坤龙
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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