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Photoacoustic imaging contrast agent for cancer diagnosis, preparation method and application thereof

A cancer diagnosis and photoacoustic imaging technology, applied in the fields of nanotechnology and cancer diagnosis, to achieve excellent tumor targeting, rich surface groups, and excellent real-time effects

Inactive Publication Date: 2018-06-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as the inventors know, at present, there is no report on the use of MXene material as a photoacoustic imaging contrast agent for cancer diagnosis

Method used

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  • Photoacoustic imaging contrast agent for cancer diagnosis, preparation method and application thereof
  • Photoacoustic imaging contrast agent for cancer diagnosis, preparation method and application thereof
  • Photoacoustic imaging contrast agent for cancer diagnosis, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Ti 3 AlC 2 Synthesis of MXenes

[0054] Titanium powder (99.5% (w / w) purity, -325 mesh), aluminum powder (99.5% (w / w) purity, -325 mesh) and graphite powder (99.0% (w / w) purity, particle size less than 48μm, -300 mesh) in a molar ratio of 2:1:1, and then ball milled for 10h, pressed into a round cake under a pressure of 30MPa, and then put the round cake in the furnace under the condition of feeding argon , fired at 1500°C for 2 hours to obtain Ti 3 AlC 2 Ceramic material.

[0055] Ti 3 AlC 2After the ceramic material is ground, collect 10g of powder and place it in 60ml of 40% hydrofluoric acid aqueous solution, carry out etching reaction at room temperature for 3 days, then collect by centrifugation and wash with water and ethanol, and then disperse in 50ml Concentration of 25% (w / w) TPAOH (Tetrapropylammonium hydroxide, tetrapropylammonium hydroxide) aqueous solution was stirred at room temperature for 3 days; then centrifuged and washed with water a...

Embodiment 2

[0057] Example 2 Synthesis of MXene nanosheets wrapped in mesoporous silica

[0058] 10g of 10% (w / w) CTAC (Cetanecyltrimethylammonium chloride) aqueous solution and 0.2g of 10% (w / w) TEA (triethanolamine) aqueous solution were pre-mixed and stirred at room temperature for 10 minutes, and then 10ml of concentration was added dropwise. The Ti obtained in embodiment 1 of 0.5mg / ml 3 AlC 2 The aqueous solution of MXenes was stirred at room temperature for 1.5 hours; then, 150 μl of TEOS was added and stirred at 80° C. for 1 hour; then the precipitate was collected by centrifugation and washed 3 times with ethanol. In the above-mentioned reaction process, CTAC can be used as a mesoporous structure guiding agent by utilizing ethanol and 37% hydrochloric acid mixed solvent (V 乙醇 :V 37％盐酸 =10:1) Washed three times for 12 hours at 78°C. Thereafter, after washing 3 times with ethanol and 2 times with deionized water, the resultant was dispersed in ethanol. Carry out in-situ bright ...

Embodiment 3

[0062] On the basis of the scheme of embodiment 2, this embodiment also investigated different Ti 3 C 2 Weight ratio of MXenes, CTAC and TEA and TEOS to Ti 3 C 2 The effect of volume ratio of MXenes material aqueous solution on the microstructure of the obtained material, the results are as follows image 3 shown.

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Abstract

The invention provides a photoacoustic imaging contrast agent for cancer diagnosis and a preparation method thereof. The method comprises the following steps: (1) mixing titanium powder, aluminum powder and graphite powder for ball-milling and pressing, carrying out high-temperature sintering under the condition that argon is introduced so as to obtain a Ti3AlC2 ceramic material; (2) smashing powder obtained in the step (1) into powder, putting the powder for a hydrofluoric acid reaction, after centrifugal washing, putting the powder into a tetrapropylammonium hydroxide water solution for a stirring reaction, centrifuging and washing to obtain a Ti3C2 MXenes material; (3) dropwise adding the Ti3C2 MXenes material into a mixed water solution of CTAC and TEA, and carrying out reaction; thenadding TEOS, reacting at the temperature of 80 DEG C, centrifuging and washing to obtain mesoporous silica coated MXene nanosheets; and (4) carrying out polyethylene glycol surface modification on anobtained product in the step (3), and then carrying out covalent binding by using RGD polypeptides so as to obtain the photoacoustic imaging contrast agent. The obtained contrast agent is excellent inimaging effect.

Description

technical field [0001] The invention belongs to the technical field of nanotechnology and cancer diagnosis, and in particular relates to a photoacoustic imaging contrast agent for cancer diagnosis and its preparation method and application. Background technique [0002] In recent years, layered two-dimensional materials have been widely and deeply studied due to their unique properties, among which graphene nanosheets and black phosphorus nanosheets are the most studied. MXene is a new type of transition metal carbide or nitride material with a two-dimensional layered structure developed by Yury Gogotsi and Michel W.Barsoum of Drexel University in 2011, which has many properties similar to graphene , such as good electrical conductivity, larger specific surface area and higher strength. At present, about 70 kinds of MXene materials have been discovered, including Ti 3 C 2 、 Ti 2 C, V 2 C. Nb 2 C. Nb 4 C 3 、 Ta 4 C 3 and Ti 4 N 3 Wait. Over the years, those skill...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/22
Inventor 杨田李镇利吴寒韩骏邢昊王正
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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