Freeze-drying flash release tablet for local skin anaesthesia, as well as preparation method and application thereof
A freeze-dried flash-release, topical skin technology, applied in the field of medical anesthesia, can solve the problems of increasing the anxiety of surgical patients, easily producing bacteria on the skin surface, and waiting too long, achieving good sterilization effect, maintaining temperature, and improving permeability. Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
preparation example Construction
[0029] The preparation method of this freeze-dried flash-release tablet is as follows:
[0030]Take compound anesthetic, nano-photocatalyst, freeze-drying protective agent, soybean lecithin, hydroxypropyl methylcellulose, and polyethylene glycol and add them to the emulsification pot, then add ultra-pure water, and put them at a temperature of 65-75°C and a pressure of 600- Homogeneously emulsify for 20 to 30 minutes at 800 bar and 1500 to 2000 rpm to obtain an emulsion, fill the emulsion into a cavity formed by double aluminum diaphragms, place it on the plate of the freeze dryer, and quickly cool down to -160 to Perform deep-condensation drying at -120°C for 1.5 to 2.0 hours, then gradually increase the temperature to 25°C, take it out and seal it, and obtain freeze-dried flash-release tablets. The gradient temperature rise is divided into five stages: Stage 1, gradually increase the temperature to -100°C within 10 hours; stage 2, gradually increase the temperature to -70°C ...
Embodiment 1
[0034] Preparation of compound anesthetic: Add 1g of toadstool, 1.5g of Aconitum aconitum extract, 1.5g of Aconitum aconitum extract, 2g of Zanthoxylum bungeanum extract, and 4g of peppermint extract into 150mL of 5wt% ethanol solution, stir until completely dissolved, and then add 30g of After phosphatidylcholine was stirred for 10 minutes, it was ultrasonically oscillated at 50-60°C for 20 minutes, and vacuum-dried to obtain complex liposomes; 24.3g trehalose and 2.4g hyaluronic acid were dissolved in phosphate buffer solution with pH=6.5 to obtain Protective solution, adding complex liposomes into the protective solution and stirring for 10 minutes, followed by ultrasonication in an ice bath at 50-60° C. for 20 minutes, and freeze-drying to obtain a compound anesthetic.
[0035] Preparation of nanophotocatalyst: 5g of anatase-type titanium dioxide with a spongy porous structure was dispersed in 120mL of absolute ethanol, then 2.5g of γ-methacryloxypropyltrimethoxysilane (MPS...
Embodiment 2
[0038] Preparation of compound anesthetic: Add 0.5g of toad venom, 2.0g of Aconitum aconitum extract, 1.0g of Aconitum aconitum extract, 2g of Zanthoxylum bungeanum extract, and 4g of peppermint extract into 150mL of 5wt% ethanol solution, stir until completely dissolved, and then add After stirring 30g of phosphatidylcholine for 10min, ultrasonically oscillate at 50-60°C for 20min, and vacuum-dry to obtain complex liposomes; take 21.7g of trehalose and 2.17g of hyaluronic acid and dissolve them in a phosphate buffer solution with a pH of 6.5. The protective solution was obtained, the complex liposome was added into the protective solution and stirred for 10 minutes, then ultrasonicated in an ice bath at 50-60° C. for 20 minutes, and freeze-dried to obtain a compound anesthetic.
[0039] The preparation of the nano photocatalyst is the same as that of the nano photocatalyst in Example 1.
[0040] Preparation of lyophilized flash-release tablets: Take 15g of compound anesthetic...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com