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Styrene-based compound and preparation method and application thereof

A technology for compounds and bases, applied in the field of styrenyl compounds and their preparation, can solve problems such as drug resistance caused by treatment plans

Active Publication Date: 2018-06-12
包骏
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although many new treatment options are initially available for patients with B-cell malignancies, nearly all patients become resistant to currently available treatment options

Method used

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  • Styrene-based compound and preparation method and application thereof
  • Styrene-based compound and preparation method and application thereof
  • Styrene-based compound and preparation method and application thereof

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Embodiment Construction

[0037] A styryl compound of the present invention, which at least contains 5-(4-(4-(3,5-dihydroxystyryl)phenoxy)styryl)-1,3-benzene of the following structural formula Diphenol compounds:

[0038]

[0039] The preparation reaction formula of the 5-(4-(4-(3,5-dihydroxystyryl) phenoxy) styryl)-1,3-benzenediol compound of the above structural formula is as follows:

[0040]

[0041] The 5-(4-(4-(3,5-dihydroxystyryl)phenoxy)styryl)-1,3-benzenediol compound of the above structural formula is prepared by the following method:

[0042] 1. Preparation of C9-1

[0043] The reaction formula is as follows:

[0044]

[0045] ①Feeding:

[0046]

[0047]

[0048] ②Operation and phenomenon:

[0049] Put 25.0g of SM1 into a 500ml single-necked bottle, add 250ml of DCM and stir to disperse evenly, then add 46.0g of thionyl chloride dropwise at room temperature, then add 5 drops of catalytic amount of DMF, and heat up to reflux after adding;

[0050] After stirring and react...

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Abstract

The invention discloses a styrene-based compound, which is at least a 5-(4-(4-(3,5-dyhydroxystyryl)phenoxyl)styryl)-1,3-benzenediol compound of the following structural formula. The invention also discloses a preparation method and application of the 5-(4-(4-(3,5-dyhydroxystyryl)phenoxyl)styryl)-1,3-benzenediol compound of the structural formula. The 5-(4-(4-(3,5-dyhydroxystyryl)phenoxyl)styryl)-1,3-benzenediol compound disclosed by the invention is used for inhibiting the abnormal growth of B-cells by lowering AKT / mTOR signal conduction. The formula is shown in the specification.

Description

technical field [0001] The invention relates to the technical field of preparation of medicines for treating autoimmune diseases and B-cell malignant tumors, in particular to a phenenyl compound and its preparation method and application. Background technique [0002] The development of B cells in the bone marrow can go through several stages of pro-B cells (pro-B cells), pre-B cells, immature B cells, activated B cells and mature B cells. The main changes in different stages of B cell differentiation in the bone marrow are the rearrangement of immunoglobulin genes and the expression of membrane surface markers. During the process of development and differentiation, B cells also undergo selection to remove non-functional gene rearranged B cells and self-reactive B cells, forming a pool of mature B cells around them. At this stage, mature B cells can continue to differentiate into plasma cells that synthesize and secrete antibodies after antigen stimulation, that is, the ant...

Claims

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Application Information

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IPC IPC(8): C07C41/34C07C41/26C07C43/295A61K31/09A61P37/02A61P29/00A61P19/02A61P13/12A61P11/00A61P1/16A61P1/04
CPCC07C41/26C07C41/30C07C41/34C07C43/285C07C43/295C07C45/00C07C45/68C07C47/575C07C51/60C07C65/24C07C259/10
Inventor 包骏陈海铭
Owner 包骏
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