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Method for synthesizing trans-3-hydroxy cyclobutyl formic acid

A technology of hydroxycyclobutyl carboxylate and hydroxycyclobutyl, which is applied in the field of synthesis of trans-3-hydroxycyclobutyl carboxylic acid, can solve problems such as poor stereoselectivity, low yield, and difficulty in scaling up industrial production, and achieve a reaction Mild, high yield, cost-saving effect

Active Publication Date: 2018-06-08
上海毕得医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technical problem that the present invention solves is, the yield of synthesizing trans-3-hydroxycyclobutyl carboxylate in the prior art is low, stereoselectivity is poor and is difficult to enlarge problems such as industrial production

Method used

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  • Method for synthesizing trans-3-hydroxy cyclobutyl formic acid
  • Method for synthesizing trans-3-hydroxy cyclobutyl formic acid
  • Method for synthesizing trans-3-hydroxy cyclobutyl formic acid

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Embodiment 1

[0047] The preparation of embodiment 1 cis-3-hydroxycyclobutyl carboxylate methyl ester

[0048] Dissolve methyl 3-carbonyl-cyclobutanecarboxylate (3075g, 24.0mol, 1.0eq.) in 30L tetrahydrofuran, cool down to -78~-60°C, add dropwise 20L lithium tri-tert-butoxy aluminum hydride (9154g , 36.0mol, 1.5eq.) tetrahydrofuran solution, after 4 hours of heat preservation reaction, TLC test after the completion of the reaction, dropwise added 6mol. L -1 The reaction was quenched with hydrochloric acid, the pH of the reaction solution was adjusted between 5 and 6, and the temperature was controlled at about 0°C. 20L of ethyl acetate was added to dilute and stirred for 30min. Pad Celite to filter, the filter cake was washed 3 times with ethyl acetate, and the filtrate was separated. The aqueous phase was extracted and washed with ethyl acetate, all organic phases were combined, dried, and concentrated to obtain light yellow liquid methyl cis-3-hydroxycyclobutylcarboxylate (2733 g, 21.0 ...

Embodiment 2

[0051] The preparation of embodiment 2 cis-3-hydroxycyclobutyl carboxylate methyl ester

[0052] Dissolve methyl 3-carbonyl-cyclobutanecarboxylate (3075g, 24.0mol, 1.0eq.) in tetrahydrofuran (30L), cool down to -78~-60°C, add dropwise tetrahydrofuran solution of lithium triethylborohydride (43L, 36.0mol, 1.5eq.), heat preservation reaction 6h, TLC test after the completion of the reaction, drop 6mol. L -1 The reaction was quenched with hydrochloric acid, the pH of the reaction solution was adjusted between 5 and 6, and the temperature was controlled at about 0°C. 20L of ethyl acetate was added to dilute and stirred for 30min. Pad diatomaceous earth to filter, the filter cake is washed 3 times with ethyl acetate, the filtrate liquid separation, the organic phase and the water phase are separated, wherein the water phase is extracted with ethyl acetate again, all organic phases are combined, dried and concentrated to obtain a light yellow liquid Formula - methyl 3-hydroxycyclo...

Embodiment 3

[0054] The preparation of embodiment 3 trans-p-nitrobenzoic acid (3-methoxycarbonyl cyclobutyl) ester

[0055] Dissolve methyl cis-3-hydroxycyclobutylcarboxylate (2730g, 21.0mol, 1.0eq) prepared in Example 1 in tetrahydrofuran (30L), cool to -10°C, add p-nitrobenzoic acid (4178g , 25.0mol, 1.2eq.), diethyl azodicarboxylate (4354g, 25.0mol, 1.2eq.), triphenylphosphine (6557g, 25.0mol, 1.2eq.). Then, under the protection of nitrogen, the mixture was stirred overnight at room temperature for 16 h. TLC detected that the reaction was complete, the tetrahydrofuran was rotated off, methyl tert-butyl ether (20 L) was added, and stirred for 0.5-1 h. Filter and wash the filter cake twice with methyl tert-butyl ether. All filtrates were collected and the filtrate was washed with saturated aqueous sodium bicarbonate solution. Liquid separation, drying and concentration. The crude product was then slurried with a mixed solvent of ethyl acetate / petroleum ether, filtered, and concentrate...

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Abstract

The invention belongs to the field of organic synthesis and discloses a method for synthesizing trans-3-hydroxy cyclobutyl formic acid. The method comprises the following steps: by using an appropriate reducing agent, reducing 3-carbonyl-cyclobutane formate (C1-C6 alkyl ester) into single trans-3-hydroxy cyclobutyl formic ether in an efficient stereoselectivity manner, and further performing a Mitsunobu reaction and hydrolysis, thereby obtaining single trans-3-hydroxy cyclobutyl formic acid. The method provided by the invention is high in synthesis method raw material availability, mild in reaction condition, good in stereoselectivity and relatively high in yield; in addition, aftertreatment and purification are both easy to operate, and the method is applicable to industrial amplified production.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a synthesis method of trans-3-hydroxycyclobutanecarboxylic acid. Background technique [0002] Trans-3-hydroxycyclobutanecarboxylic acid is an important pharmaceutical intermediate, because of its unique stereochemical structure properties (cyclobutyl unit and trans structure), it is widely used in the fields of biology and medicine. For example, butorphanol metabolites and NTRK kinase inhibitors are involved in the use of this compound. Cis / trans-3-hydroxycyclobutyl carboxylate also plays an important role in the construction of biologically active structural molecules. Such as synthesizing various inhibitors, such as CETP inhibitors, CDK9 inhibitors, CXCR2 inhibitors, etc. At present, there are few synthetic methods of trans-3-hydroxycyclobutylcarboxylic acid reported in the literature, and there are few reports on the intermediate trans-3-hydroxycyclobutyl carbox...

Claims

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Application Information

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IPC IPC(8): C07C51/09C07C62/02
CPCC07C51/09C07C67/31C07C201/12C07C62/02C07C205/57C07C69/757
Inventor 熊诗传米涛冉樊俭俭张锐豪
Owner 上海毕得医药科技股份有限公司
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