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A kind of magnetotactic bacterial quantum dot microcapsule and preparation method thereof

A technology of magnetotactic bacteria and microcapsules, applied in the preparation of magnetotactic bacteria quantum dot microcapsules, and the field of magnetotactic bacteria quantum dot microcapsules, can solve the problems of inability to reach, increase in particle size, and deteriorate stability, etc. Good colloidal stability, good dispersion, good biocompatibility

Active Publication Date: 2021-01-26
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Magnetosome particles are single magnetic domain crystals, uniform in size, nanoscale (20-120nm), and have a large specific surface value. They are coated with biofilm outside the particles, do not produce cytotoxicity, and have excellent biocompatibility. However, due to the high specific surface area of ​​exposed magnetosomes, it is easy to induce aggregation between particles, resulting in increased particle size and poor stability, which cannot meet the requirements of biomedical applications.

Method used

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Examples

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preparation example Construction

[0038]The present invention also provides a method for preparing the magnetotactic bacteria quantum dot microcapsules, which includes the following steps:

[0039]In step (1), 300 mg of natural graphene was added to a mixed solution of 60 mL of concentrated sulfuric acid and 20 mL of concentrated nitric acid. The mixture was first sonicated for 2 hours to be uniformly dispersed, and then stirred and refluxed at 100° C. for 24 hours. The brown-black solution is first cooled to room temperature, and then diluted with deionized water to a total volume of about 800 mL. Then add sodium carbonate to neutralize the remaining acid until the pH of the solution is around 8. The obtained solution is concentrated by rotary evaporation, and a large amount of precipitated inorganic salt is filtered off. The collected filtrate is dialyzed with a dialysis bag with a cut-off molecular weight of 8000-14000 for four days to obtain an aqueous solution of pure carbon quantum dots. Freeze and drain the aque...

Embodiment 1

[0053]A method for preparing magnetotactic bacteria quantum dot microcapsules, the steps include:

[0054]Step (1) 300 mg of natural graphene was added to a mixed solution of 60 mL of concentrated sulfuric acid and 20 mL of concentrated nitric acid, and the mixture was first sonicated for 2 hours to be uniformly dispersed, and then stirred and refluxed at 100° C. for 24 hours. The brown-black solution is first cooled to room temperature, and then diluted with deionized water to a total volume of about 800 mL. Then add sodium carbonate to neutralize the remaining acid until the pH of the solution is around 8. The obtained solution is concentrated by rotary evaporation, and a large amount of precipitated inorganic salt is filtered off. The collected filtrate is dialyzed with a dialysis bag with a cut-off molecular weight of 8000-14000 for four days to obtain an aqueous solution of pure carbon quantum dots.

[0055]In the above step (1), the aqueous solution of carbon quantum dots is freeze-...

Embodiment 2

[0061]A method for preparing magnetotactic bacteria quantum dot microcapsules, the steps include:

[0062]Step (1) 300 mg of natural graphene was added to a mixed solution of 60 mL of concentrated sulfuric acid and 20 mL of concentrated nitric acid, and the mixture was first sonicated for 2 hours to be uniformly dispersed, and then stirred and refluxed at 100° C. for 24 hours. The brown-black solution is first cooled to room temperature, and then diluted with deionized water to a total volume of about 800 mL. Then add sodium carbonate to neutralize the remaining acid until the pH of the solution is around 8. The obtained solution is concentrated by rotary evaporation, and a large amount of precipitated inorganic salt is filtered off. The collected filtrate is dialyzed with a dialysis bag with a cut-off molecular weight of 8000-14000 for four days to obtain an aqueous solution of pure carbon quantum dots. Freeze and drain the aqueous solution of carbon quantum dots to obtain a solid car...

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PUM

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Abstract

The present invention proposes a magnetotactic bacterial quantum dot microcapsule, the inner core of the microcapsule is a magnetosome, and the surface of the magnetosome is wrapped with a mixture of uniform and dense chitosan / γ-polyglutamic acid / carbon quantum dots; The mass ratio of the magnetosomes to chitosan, γ-polyglutamic acid and carbon quantum dots is 1:1-3:10-20:1. The preparation method of the magnetotactic bacterial quantum dot microcapsules of the present invention is simple to operate, and the obtained magnetosomes and carbon quantum dot smart microcapsules present a typical core-shell structure, and the quantum dot microcapsules have the ability of targeting and slow release, It has a great clinical application prospect.

Description

Technical field[0001]The invention relates to the field of biomedicine, in particular to a magnetotactic bacteria quantum dot microcapsule, and also to a preparation method of the magnetotactic bacteria quantum dot microcapsule.Background technique[0002]The delivery method of drugs has a crucial impact on the therapeutic effect of cancer, and the delivery of tumor-targeted drugs is very challenging. With the deepening of nanotechnology in the field of biomedicine, magnetic nanomaterials have also received a lot of attention. Magnetotactic bacterium (Magnetotactic bacterium) is a type of bacteria that can move in a directional motion under the action of an external magnetic field and form nano-magnetic particles in the body-magnetosome (Magnetosome). In recent years, magnetotactic bacteria and magnetosomes have become new The biological resources are widely studied in materials science, medicine, biology, physics, geology and other disciplines, and have been applied in many fields su...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/46A61K47/36A61K47/34A61K47/04A61K9/00A61K31/704A61K41/00A61P35/00
CPCA61K9/0009A61K9/501A61K9/5031A61K9/5036A61K31/704A61K41/0052A61K47/46A61K2300/00
Inventor 杨革李媛车程川巩志金梁鑫鑫
Owner QUFU NORMAL UNIV
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