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Method for processing glycyrrhiza polysaccharide freeze-dried powder

A technology of licorice polysaccharide and processing method, which is applied in freeze-drying transportation, powder transportation, pharmaceutical formulation and other directions, can solve the problems of reduction of heat-sensitive active substances, short shelf life and high moisture content, and achieves less loss of active components and long shelf life. , the effect of low water content

Inactive Publication Date: 2018-05-29
北京佑众全椒制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN1473571A proposes a new medicinal use of licorice polysaccharide and its pharmaceutical preparation. Glycyrrhizin polysaccharide tablets are obtained by mixing licorice polysaccharide, excipients and other components of drugs, and drying at 55°C for 2 hours; Chinese patent CN102511716A discloses a A preparation method of licorice polysaccharide granules, mixing and granulating licorice polysaccharide powder, fillers, binders and water, drying at a temperature of 45-60°C for 5 hours to prepare licorice polysaccharide granules, but the drying temperature is high and the time is short. Glycyrrhiza polysaccharide granules have reduced heat-sensitive active substances, high moisture content, short shelf life, and low efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A processing method of licorice polysaccharide freeze-dried powder, comprising the steps of:

[0019] S1. Add licorice polysaccharides, amino acids, and mannitol into a sterile container, add water for injection, stir well, and then add sodium acetate to prepare a solution with a pH of 7.0;

[0020] S2, filter the solution through a microporous membrane with a pore size of 0.22 μm to obtain a sterile solution;

[0021] S3. Cool the sterile solution from room temperature to -38°C over 0.5h, keep it for 15min, return to -5°C, cool down to -38°C after 1h, evacuate to -550mmHg, heat up to -20°C after 3h, keep After 2 hours, the temperature was raised to 16° C. over 5 hours to prepare lyophilized glycyrrhiza polysaccharide powder with a water content of 4.5%.

Embodiment 2

[0023] A processing method of licorice polysaccharide freeze-dried powder, comprising the steps of:

[0024] S1. Add licorice polysaccharide, amino acid, mannitol, polyethylene glycol, and glucose into a sterile container, add water for injection, stir well, add sodium acetate, sodium carbonate, and prepare a solution with a pH value of 8.0;

[0025] S2, filter the solution through a microporous membrane with a pore size of 0.20 μm to obtain a sterile solution;

[0026] S3. Cool the sterile solution from room temperature to -28°C over 1.5h, keep it for 30min, return to -10°C, cool down to -28°C after 0.3h, evacuate to -400mmHg, heat up to -16°C after 5h, Keep it for 5 hours, then raise the temperature to 16° C. over 8 hours to prepare licorice polysaccharide freeze-dried powder with a water content of 3.5%.

Embodiment 3

[0028] A processing method of licorice polysaccharide freeze-dried powder, comprising the steps of:

[0029] S1. Add licorice polysaccharide, polyethylene glycol, and glucose into a sterile container, add water for injection, stir evenly, add ammonia water, and sodium carbonate to obtain a solution with a pH value of 7.3;

[0030] S2, filter the solution through a microporous membrane with a pore size of 0.20 μm to obtain a sterile solution;

[0031] S3. Cool the sterile solution from room temperature to -31°C over 0.8h, keep it for 20min, return to -7°C, cool down to -31°C after 0.5h, evacuate to -450mmHg, and heat up to -19°C after 3.5h , kept for 2.5 hours, and heated up to 18° C. over 6 hours to prepare lyophilized glycyrrhiza polysaccharide powder with a water content of 4.0%.

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Abstract

The invention discloses a method for processing glycyrrhiza polysaccharide freeze-dried powder. The method comprises the following steps: putting glycyrrhiza polysaccharide and an excipient into a sterile container, adding injection water, uniformly stirring, and adding a pH value buffer solution so as to obtain a solution; filtering and sterilizing the solution by using a micro-pore filtering membrane so as to obtain a sterile solution; and cooling the sterile solution, vacuuming, and performing heating drying, thereby obtaining the glycyrrhiza polysaccharide freeze-dried powder. The glycyrrhiza polysaccharide freeze-dried powder processed by using the method has the advantages of being loosened in morphology, high in resolubility, small in active component loss and easy in long-term preservation, and is simple and convenient in processing method, relatively low in cost and wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of freeze-dried powder processing, in particular to a processing method of licorice polysaccharide freeze-dried powder. Background technique [0002] Licorice, also known as Guolao, sweet grass, Ural licorice, sweet roots, is the dried root and rhizome of leguminous licorice, bloated licorice or glabra. Chinese herbal medicine for clearing away heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain. It is often used for weak spleen and stomach, fatigue, palpitations, shortness of breath, cough with excessive phlegm, abdominal distension, acute pain in limbs, carbuncle and sore, and relieve drug toxicity and potency. Licorice contains a variety of active ingredients, mainly triterpenoids, flavonoids, and licorice polysaccharides. [0003] Glycyrrhiza polysaccharide is a reducing polysaccharide mainly composed of α-glucoside, light yellow and white powder, soluble ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/715A61K47/18A61K47/26A61K47/10A61P37/04A61P31/18A61P31/20A61P31/14A61P35/00A61P39/06
CPCA61K9/19A61K31/715A61K36/484A61K47/10A61K47/183A61K47/26
Inventor 陈光
Owner 北京佑众全椒制药有限公司
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