Application of caffeic acid to prepare anti-HPV-virus-infection medicine

Abstract

The invention discloses an application of caffeic acid to prepare an anti-HPV-virus-infection medicine, and belongs to the biomedical field. Through research, it is first found by the inventor that caffeic acid has good anti-HPV-virus-infection activity and can effectively block adhesion of HPV viruses to target cells, so that HPV virus infection is inhibited. It is proved by experiments that caffeic acid can directly combine with capsid protein of viruses and antagonize adhesion of viruses to target cells, thereby achieving the anti-virus effect. Caffeic acid acts in an early stage when viruses enter cells and acts in medium and later stages after virus entrance. The anti-HPV-virus-infection medicine has an effect superior than that of a medicine that only acts in an early stage when viruses enter cells in the prior art. At the same time, caffeic acid is harmless to the human body in a concentration range, during which caffeic acid has an anti-virus function, and is high in use valueand good in safety. Caffeic acid has likely possibility of becoming a new microbicide for next-generation prevention and treatment of infection of sexual transmission viruses, such as HPV.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a new application of caffeic acid. Background technique [0002] Human papillomavirus (human papillomavirus, HPV) is a kind of epitheliophilic virus, belonging to papillomavirus genus of Papovaviridae, is a kind of non-enveloped double-stranded circular epitheliophilic DNA with small molecular weight (7.9Kb) Virus. There are currently about 200 different subtypes of HPV, which are divided into low-risk and high-risk types according to their pathogenicity. Low-risk HPVs mainly cause low-grade lesions at the site of infection, genital or skin warts, and condyloma acuminatum, while high-risk HPVs mainly cause high-grade lesions at the site of infection and invasive cancer. At the same time, the persistent infection of high-risk HPV has been proved to be an important risk factor for the occurrence of cervical cancer. Epidemiological studies have shown that 90% of cervical can...

AI Technical Summary

Problems solved by technology

Although RNA interference (RNAi) nucleotide analogs can interfere with the expression of HPV virus-related genes to achieve antiviral effects, they only work at the post-transcriptional level and have no impact on the incubation period of the virus. Therefore, RNAi nucleosides Acid analogs cannot be used alone in the treatment of HPV-related diseases

In addition, antioxidants and herbal derivatives have also shown effective therapeutic potential for HPV infection, and the research results of herbal derivatives are the most notable, such as Berberine, Curcumin, Norda Hydrogen Generic acid (NGDA), EGCG, etc., these herbal derivatives can partially inhibit the diseases caused by HPV infection by blocking the transcription of viral genes or antagonizing the function of viral proteins, but these drugs have shown high antiviral efficacy in the research and development stage. effect, but it is forbidden for pregnant women. In addition, during clinical research, the above-mentioned drugs were shelved due to safety and effectiveness issues, resulting in the failure of research and development

[0006] At the same time, a group of antimicrobial candidate drugs, such as Praneem, Carrageenan, curcumin polymeric herbal preparation Basant and JB01-BD, can prevent HPV infection by blocking HPV virus from invading human cells effect, but again, their role is limited to the prevention of HPV infection, and cannot be treated in the case of HPV infection

It is speculated that it may be because the above candidate drugs mainly work before the virus invades the cells, and the effect is not good after the virus invades the cells and reproduces in large numbers

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