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Preparation and application of sodium allylsulfonate (SAS) and cetylpyridinium chloride(CPC) compound gel

A technology of cetylpyridinium chloride and sodium azulene, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, active ingredients of anhydride/acid/halide, etc., and can solve the problem of single function, sodium azulene and cetyl Ammonium chloride is unstable, volatile and other problems, to achieve the effect of inhibiting or killing microorganisms, good anti-inflammatory, antibacterial and therapeutic effects, and prevention and treatment of oral ulcers

Inactive Publication Date: 2018-05-15
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the fact that there are some irritating ingredients such as alcohol in the mouthwash on the market, the retention time in the mouth is short, the function is single, and sodium azulenate and cetylpyridinium chloride are unstable and volatile

Method used

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  • Preparation and application of sodium allylsulfonate (SAS) and cetylpyridinium chloride(CPC) compound gel
  • Preparation and application of sodium allylsulfonate (SAS) and cetylpyridinium chloride(CPC) compound gel
  • Preparation and application of sodium allylsulfonate (SAS) and cetylpyridinium chloride(CPC) compound gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: antibacterial experiment

[0015] Experimental strains: Escherichia coli, Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, Streptococcus mutans, Actinobacillus actinomycetes.

[0016] Strain medium: LB plate, CDC anaerobic blood plate, common blood plate and nutrient broth medium.

[0017] Experimental group preparation: take 0.1g sodium azulene xanthate and dissolve it in 100ml sodium azulene xanthate gargle blank (the blank of azulene xanthate gargle is Blank: non-crystalline sorbitol, sodium benzoate, RH40 hydrogenated castor oil, propylene glycol , spearmint essence, ethanol, purified water), be mixed with 0.1% sodium azulexanate solution, and obtain 0.03% sodium azulexanate by dilution; take 0.2g cetylpyridinium chloride and dissolve it in 100ml sodium azulexanate In the gargle blank, it is configured into 0.2% cetylpyridinium chloride solution, and 0.05% cetylpyridinium chloride solution is obtained by dilu...

Embodiment 2

[0031] An anti-inflammatory and antibacterial compound jelly, the raw materials for making said compound jelly are: 0.03% sodium azulene sulfonate solution and 0.05% cetylpyridinium chloride solution (CPC) (broad-spectrum bactericidal)

Embodiment 3

[0033] An anti-inflammatory and antibacterial compound jelly. The raw materials for making the compound jelly are: 0.03% sodium azulenic acid solution, 0.05% cetylpyridinium chloride solution and a blank sodium azulenic acid periodontal care gel.

[0034] Select 24 ICR male mice (25-30g), use 50% acetic acid (glacial acetic acid) to induce mucosal oral ulcer model, divide into 5 groups randomly (Blank group, CPC+SAS group and CPC+SAS Gel group), each group 8 The mice in each group were marked and numbered 1-8. Observe the behavior of the mice and the situation of eating and drinking water every day, record the daily body weight of the mice and perform data analysis (see appendix figure 1 ). At the same time, observe the wound surface, including the size of the ulcer, redness, swelling, gray pseudomembrane, and exudate, and make a comprehensive score on the wound surface: 0-the initial wound of the model, red and swollen, gray pseudomembrane; 1-wound not converged, gray The p...

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Abstract

The invention discloses preparation and application of sodium allylsulfonate(SAS) and cetylpyridinium chloride(CPC) compound gel and belongs to the technical field of pharmaceutic preparation. The compound gel is prepared from SAS 0.03% and CPC 0.05% and the rest being xanthan gum. The compound gel plays an important role in treatment of stomatology, and its safety and repairing capacity to woundsurfaces affect clinical treatment effect. The compound gel with anti-inflammatory bacteriostasis has good repair effect to dental ulcer, and has the advantages of high safety and capacity of repairing wound surfaces of dental ulcer rapidly.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and is an anti-inflammatory and antibacterial compound gel. Background technique [0002] Sodium azulene is an active ingredient of chamomile. Its pharmacological mechanism is to directly inhibit the migration of white blood cells to the outside of the body, inhibit the release of histamine from mast cells and the synthesis of PGE2, directly and permanently inhibit the inflammation caused by various inflammatory substances, and promote the synthesis of granulation and repair of epithelial cells. It is often used in the treatment of diseases such as gastric and duodenal ulcers. Sodium azulenic acid has been used in oral care in developed countries such as Japan and Europe. However, sodium azulene xanthate is used to treat oral diseases only in aqueous solution, which has disadvantages such as inconvenient to carry and instability. [0003] Cetyl pyridinium chloride is cetyl p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4425A61K31/185A61K47/36A61K9/00A61P1/02A61P29/00A61P31/02
CPCA61K31/4425A61K9/006A61K31/185A61K47/36A61K2300/00
Inventor 龚爱华程洁唐宇韩秀陈曦曾建刘菲许婧
Owner JIANGSU UNIV
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