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Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride mouthwash

A technology of nisin and cetylpyridinium chloride, applied in the field of personal hygiene care, can solve problems such as user discomfort, wound or wound surface irritation, etc., and achieve the effects of preventing and treating oral ulcers, improving antibacterial, anti-inflammatory and therapeutic effects

Inactive Publication Date: 2018-03-06
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main components of mouthwashes on the market are essence, surfactant, fluoride, alcohol and water, etc., because some mouthwashes contain stimulating ingredients such as alcohol, which have a certain stimulating effect on wounds or wounds, so that users will feel uncomfortable sense

Method used

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  • Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride mouthwash
  • Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride mouthwash
  • Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride mouthwash

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: antibacterial experiment

[0014] Experimental strains: Escherichia coli, Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, Streptococcus mutans, Actinobacillus actinomycetes.

[0015] Strain medium: LB plate, CDC anaerobic blood plate, common blood plate and nutrient broth medium.

[0016] The purpose of the antibacterial experiment is to screen out the optimum concentration of our selected drugs (cepyridinium chloride, sodium fluoride, nisin) and propose our formula.

[0017] Specific experimental steps:

[0018] Preparation of bacterial liquid: put Escherichia coli, Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, Streptococcus mutans, and Actinobacillus actinomycetes in nutrient broth medium for 12 hours at 37°C -18h; take 1ml of the culture solution and add 9ml of 0.9% sterile sodium chloride solution, and use the 10-fold incremental dilution method to dilute to 100...

Embodiment 2

[0037] A kind of antibacterial antiphlogistic mouthwash, the raw material that makes described mouthwash is: 0.05% cetylpyridinium chloride (CPC) (broad-spectrum sterilization)

Embodiment 3

[0039] An antibacterial and anti-inflammatory mouthwash, the raw material for making said mouthwash is: 0.01% Nisin (NISIN) (for some Gram-positive bacteria)

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Abstract

The invention discloses preparation and application of nisin, cetylpyridinium chloride and sodium fluoride mouthwash and belongs to the technical field of personal hygiene care. The mouthwash has important effects in oral medicine. However, safety and wound restoration capability of the mouthwash influence the clinical effect. The antibacterial anti-inflammatory mouthwash has an obvious restoration effect on oral ulcer, contains natural antibacterial anti-inflammatory components and has the advantage of rapid restoration of oral ulcer wound.

Description

technical field [0001] The invention belongs to the technical field of personal hygiene care, and relates to a compound mouthwash for treating oral ulcers. Background technique [0002] Nisin is a small molecule polypeptide compound composed of amino acids produced by the fermentation of Streptococcus lactis, which can effectively inhibit the growth of Gram-positive bacteria, and also has a strong effect on bacteria such as Streptococcus mutans and Lactobacillus that cause dental caries. inhibitory effect. Many countries and regions have approved it as a food preservative, and it is used in canned food, vegetable protein food, dairy products and meat products. Because it is easily degraded by some proteases in the human digestive tract and will not accumulate in the human body, it is a safe and natural preservative recognized worldwide. Currently, nisin is not used in oral care products. Therefore, the use of nisin in oral mouthwashes remains to be developed. [0003] Ce...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K9/08A61P1/02A61P29/00A61P31/02A61K31/44A61K33/16
Inventor 龚爱华程洁唐宇韩秀陈曦曾建刘菲许婧
Owner JIANGSU UNIV
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