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Application of resveratrol to preparation of drugs for treating or relieving chronic airway inflammation

A technology of resveratrol and airway inflammation, which is applied in the field of resveratrol used in the preparation of medicines for treating or alleviating chronic airway inflammatory diseases, and can solve the problem that resveratrol cannot effectively use chronic airway inflammation Diseases and other problems, to achieve the effect of reducing drug dosage, obvious curative effect, and increasing drug concentration

Inactive Publication Date: 2018-05-08
SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem that resveratrol cannot be effectively used in the treatment of chronic airway inflammatory diseases such as asthma, and provides an inhalant containing resveratrol, which can be administered locally by inhalation to treat or alleviate the disease. achieved satisfactory results

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  • Application of resveratrol to preparation of drugs for treating or relieving chronic airway inflammation
  • Application of resveratrol to preparation of drugs for treating or relieving chronic airway inflammation
  • Application of resveratrol to preparation of drugs for treating or relieving chronic airway inflammation

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Embodiment Construction

[0023] The technical solutions of the present invention will be further described below in conjunction with examples and accompanying drawings.

[0024] The preparation method of the nebulizer containing resveratrol:

[0025] The resveratrol monomer was purchased from selleck company, and the preparation instruction shows: resveratrol (3-4'-5-trihydroxystilbene) is a non-flavonoid polyphenol compound with a molecular formula of C14H12O3 and a molecular weight of 228.24, -20 Stored at ℃ for three years, the appearance is colorless needle-like crystals, odorless, insoluble in water and ethanol, easily soluble in dimethyl sulfoxide (DMSO), melting point 256-258 ℃, sublimation temperature 261 ℃.

[0026] Resveratrol powder was added to DMSO to prepare 40 μg / μl resveratrol stock solution and stored at -20°C. The high-dose group (30mg / kg / d) atomized liquid preparation method is: 4.8ml normal saline + 0.12ml resveratrol stock solution; the medium-dose group (3mg / kg / d) atomized liqui...

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Abstract

The invention discloses application of resveratrol to the preparation of drugs for treating or relieving chronic airway inflammation (asthma and chronic obstructive pulmonary). According to the method, chronic airway inflammation, such as asthma, is treated in a mode of aerosol inhalation of resveratrol, the curative effect is obvious, and the dosage of resveratrol can be greatly reduced; in addition, compared with oral or injection drugs, the mode of inhalation of resveratrol can increase the local drug concentration, namely the drug concentration at the lungs of asthma mice is increased, a drug directly acts on the lungs of the mice, the target is clear, the drugs directly act on the lungs, damage to other visceral organs is reduced, the drug loss is small, and the drugs have a good application prospect.

Description

technical field [0001] The present invention relates to a new use of resveratrol, in particular to the use of resveratrol in the preparation of medicines for treating or alleviating chronic airway inflammatory diseases (such as asthma and chronic obstructive pulmonary disease). Background technique [0002] Bronchial asthma (referred to as asthma) is a common disease. There are about 300 million asthmatics in the world, and about 20 million people in my country suffer from asthma, and the incidence rate is still increasing year by year. Due to repeated attacks of asthma and high medical expenses, causing Its family and society have a heavy burden, and it has become one of the diseases that seriously affect human health and quality of life. Western medicine anti-inflammatory, antispasmodic, inhaled glucocorticoids and other drugs have obvious effects on asthma in the attack stage, but there are serious drug resistance and drug side effects after long-term use. Literature data...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/72A61P11/00A61P11/06A61P29/00
CPCA61K31/05A61K9/0073
Inventor 王雄彪汤玲玲倪振华陈清阁孙莉胡俊晟罗旭明唐继红蔡朱莺
Owner SHANGHAI PUTUO DISTRICT CENT HOSPITAL
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