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Medicinal pellet core and preparation method thereof

A ball core and micro-pill technology, which is applied in the field of pharmaceutical micro-pill core and its preparation, can solve the problems of unstable finished product quality, particle size uniformity, roundness, and surface finish that cannot reach a satisfactory level.

Active Publication Date: 2018-04-27
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of pellet cores in the above two patents requires less equipment and simple process implementation, but the particle size uniformity, roundness and surface finish are not satisfactory, and the quality of the finished product is also unstable.

Method used

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  • Medicinal pellet core and preparation method thereof
  • Medicinal pellet core and preparation method thereof
  • Medicinal pellet core and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0023] Embodiment 2. Anhydrous glucose pellet core, wherein the dosage ratio of mother core component and centrifuge encapsulation component is 1:2

[0024]

[0025]

[0026] The preparation method is:

[0027] a. Crush and sieve each component, weigh each component according to the prescription amount, dissolve PVP K-30 in water to make an aqueous binder solution, and place the anhydrous glucose and MCC101 in the mother core component in a wet granulator After mixing evenly, add the binder aqueous solution to prepare the mother core.

[0028] b. Turn on the centrifugal packaging machine, put the prepared mother core into the centrifugal packaging machine, adjust the rotating speed, and use the anhydrous glucose and starch in the centrifugal packaging composition to supply powder while spraying the binder solution. The mother core is layered and powdered, and finally the prepared pellets are sieved.

Embodiment 3

[0029] Embodiment 3. Anhydrous glucose pellet core, wherein the consumption ratio of mother core component and centrifuge encapsulation component is 1:2.5

[0030]

[0031]

[0032]

[0033] The preparation method is:

[0034] a. Crush and sieve each component, weigh each component according to the prescription amount, dissolve PVP K-30 in water to make an aqueous binder solution, and place the anhydrous glucose and MCC101 in the mother core component in a wet granulator After mixing evenly, add the binder aqueous solution to prepare the mother core.

[0035] b. Turn on the centrifugal packaging machine, put the prepared mother core into the centrifugal packaging machine, adjust the rotating speed, and use the anhydrous glucose and MCC101 in the centrifugal packaging composition to supply powder while spraying the binder solution. The mother core is layered and powdered, and finally the prepared pellets are sieved.

Embodiment 4

[0036] Embodiment 4. Glucose monohydrate pellet core, wherein the consumption ratio of mother core component and centrifugal package composition is 1:2.5

[0037]

[0038]

[0039] The preparation method is:

[0040] a. Crush and sieve each component, weigh each component according to the prescription amount, dissolve PVP K-30 in water to make an aqueous binder solution, and place glucose monohydrate and MCC101 in the mother core component in a wet granulator After mixing evenly, add the binder aqueous solution to prepare the mother core.

[0041]b. Turn on the centrifugal packaging machine, put the prepared mother core into the centrifugal packaging machine, adjust the rotating speed, and use the glucose monohydrate and MCC101 in the centrifugal packaging composition to supply powder while spraying the binder solution. The mother core is layered and powdered, and finally the prepared pellets are sieved.

[0042] 2. Determination of traits or properties:

[0043] 1) P...

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Abstract

The invention provides a medicinal pellet core having excellent properties and excellent indexes, and a preparation method thereof, having the advantages of low requirements on the device level and convenience in industrial production. The pellet core includes a main material, a diluent and an adhesive, and is prepared by using glucose as the main material, so the pellet core can be used as a basepill for medication, and also can be used as a carbohydrate supplementing product provided for patients in clinic therapy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a medicinal pellet core and a preparation method thereof. Background technique [0002] The core of pharmaceutical pellets is a nearly spherical particle made of inert auxiliary materials or main drug and auxiliary materials. Inert ball cores are usually used as substrates and carriers in production. The drug-containing pellet core has different uses according to the differences between varieties, such as further coating with functional coatings to obtain sustained-release or delayed-release pellets with different drug-release properties. In terms of properties, for pellet cores, it is generally required to have good roundness, low friability, smooth surface, good flatness, and good fluidity, which can meet the requirements of further drug application and coating processes, or filling processes. There are many ways to prepare pellet cores, the main prepara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/26A61K47/38A61K47/36A61K47/32A61K31/7004A61P3/00
CPCA61K9/1623A61K9/1635A61K9/1652A61K9/167A61K31/7004
Inventor 张长青朱德志咸小燕宁洁张胜海
Owner 北京科信聚润医药科技有限公司
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