Tissue activity promotion type pulp capping agent and preparation method thereof

A pulp capping and active technology, applied in the field of tissue-promoting active pulp capping agent and its preparation, can solve the problems of inability to promote tissue activity, chronic persistent inflammation, root canal absorption, etc., so as to improve tissue recovery and promote repair , Improve the effect of repair performance

Inactive Publication Date: 2018-04-13
常州欧利莱照明有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problem that the calcium hydroxide in the traditional pulp capping agent can cause calcification of the root pulp tissue, chronic persistent inflammation, even pulp necrosis and root canal absorption, and cannot promote tissue activity, provide A tissue-promoting pulp capping agent and a preparation method thereof

Method used

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  • Tissue activity promotion type pulp capping agent and preparation method thereof

Examples

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Effect test

example 1

[0024] Take the vine and grind it through a 100-mesh sieve to obtain a ground powder, and mix the ground powder with a mass fraction of 75% ethanol solution at a mass ratio of 1:10, then heat and reflux at 75°C for 2 hours, then let it stand and cool to room temperature , filtered to obtain the filtrate and place it at 75°C for rotary evaporation to 1 / 5 of the volume of the filtrate to obtain a concentrated filtrate; in parts by weight, weigh 55 parts of deionized water, 10 parts of concentrated filtrate, 2 parts of OP-10, 1 part of ammonium persulfate, 10 parts of acrylamide, and 6 parts of sodium dodecylbenzenesulfonate were placed in a three-necked flask, stirred and mixed, and nitrogen gas was introduced to remove the air. The rate of nitrogen gas introduction was controlled at 45 mL / min. After the completion, it was left to stand for 20 minutes, then heated in a water bath at 45°C for 25 minutes, stirred and mixed, and allowed to stand for 20 hours to solidify to prepare a...

example 2

[0026] Take the vine and grind it through a 100-mesh sieve to obtain a ground powder, and mix the ground powder with a mass fraction of 75% ethanol solution at a mass ratio of 1:10, then heat and reflux at 77°C for 3 hours, then let it stand and cool to room temperature , filtered to obtain the filtrate and place it at 77°C for rotary evaporation to 1 / 5 of the volume of the filtrate to obtain a concentrated filtrate; in parts by weight, weigh 57 parts of deionized water, 12 parts of concentrated filtrate, 3 parts of OP-10, 2 parts of ammonium persulfate, 12 parts of acrylamide and 7 parts of sodium dodecylbenzenesulfonate were placed in a three-necked flask, stirred and mixed, and nitrogen gas was introduced to remove the air. The rate of nitrogen gas introduction was controlled at 45mL / min. After the completion, it was left to stand for 22 minutes, then heated in a water bath at 47°C for 27 minutes, stirred and mixed, and allowed to stand for 22 hours to solidify to prepare a ...

example 3

[0028] Take the vine and grind it through a 100-mesh sieve to obtain a ground powder, and mix the ground powder with a mass fraction of 75% ethanol solution at a mass ratio of 1:10, then heat and reflux at 80°C for 3 hours, then let it stand and cool to room temperature , filtered to obtain the filtrate and place it at 80°C for rotary evaporation to 1 / 5 of the volume of the filtrate to obtain a concentrated filtrate; in parts by weight, weigh 60 parts of deionized water, 15 parts of concentrated filtrate, 3 parts of OP-10, 2 parts of ammonium persulfate, 15 parts of acrylamide, and 8 parts of sodium dodecylbenzenesulfonate were placed in a three-necked flask, stirred and mixed, and nitrogen gas was introduced to remove the air. The rate of nitrogen gas introduction was controlled at 45 mL / min. After the completion, it was left to stand for 25 minutes, then heated in a water bath at 55°C for 30 minutes, stirred and mixed, and allowed to stand for 24 hours to solidify to prepare ...

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Abstract

The invention relates to a tissue activity promotion type pulp capping agent and a preparation method thereof, and belongs to the technical field of pulp capping agents. Periploca forrestii Schltr isground and undergoes alcohol extraction, the obtained alcohol extract is collected and is concentrated, an ethyl acetate component is extracted from the Periploca forrestii Schltr, and the Periploca forrestii Schltr ethyl acetate part has strong osteoclast formation and bone resorption ability inhibition activity, and can improve the activity of cell tissues at the pulp capping position, so the tissue restoration condition is used is improved after the pulp capping agent. A pearl mother material is used as a powder main material, and the main components of the pearl mother powder main materialare calcium carbonate, organic matters and few trace elements, so the pulp capping agent is similar to human skeleton in chemical components and form structure, is nontoxic to local tissues or the whole body, has no rejection reaction, has good biocompatibility and bone affinity, can promote the restoration of root apex periphery tissues, guide the growth of alveolar bone cells and seal apical foramen, and has effectively improved restoration performance.

Description

technical field [0001] The invention relates to a tissue-promoting active pulp capping agent and a preparation method thereof, belonging to the technical field of pulp capping agents. Background technique [0002] Dental pulp is a loose connective tissue located in the pulp cavity, which is derived from the ectodermal mesenchyme and is the tissue that forms dentin. Healthy dental pulp tissue is of great significance for the normal function of teeth. The functions of the pulp tissue include the continuous formation of new dentin on the side of the pulp cavity to resist external stimuli, and the continuous provision of nutrition to the hard tissue of the tooth through the dentinal tubules and the function of sensing and defending against external stimuli. Whether the pulp tissue is healthy or not is directly related to the structure and function of the tooth. After pulp necrosis, the enamel and dentin may become fragile and easily fractured due to the loss of pulp nutrition, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/02A61K6/00
CPCA61K6/69A61K6/80
Inventor 薛红娟季美
Owner 常州欧利莱照明有限公司
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