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Application of vitamin D in resisting Aspergillus fumigatus

A technology of vitamins and Aspergillus fumigatus, which is applied in the field of medicine, can solve problems such as affecting immune activity, and achieve the effect of enhancing cellular immune function and preventing excessive autophagy damage

Inactive Publication Date: 2018-03-23
NO 1 THE PEOPLES HOSPITAL HUAIAN CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The aforementioned cellular effects play a key role in host resistance to pathogens, whereas vitamin D deficiency affects their immune activity

Method used

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  • Application of vitamin D in resisting Aspergillus fumigatus
  • Application of vitamin D in resisting Aspergillus fumigatus
  • Application of vitamin D in resisting Aspergillus fumigatus

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Experimental program
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Effect test

Embodiment approach 1

[0027] animal selection

[0028] Four-week-old female BALB / c mice were housed in a specific pathogen-free environment in a small animal care facility. Mice were exposed to a 12-h light / dark cycle setting with designated diet and tap water ad libitum. Mouse body weight and health were monitored weekly. All mice were anesthetized with ether when the infection model was established.

[0029] Construction of Vitamin D Deficiency Model

[0030] After a two-week acclimatization period, BALB / c mice were divided into two groups, one group of mice were fed a vitamin D-deficient diet (VitD-), and the other group of mice were fed a vitamin D-containing diet (VitD+) , were fed for eight weeks. Foods that contain vitamin D contain 1,000 IU of vitamin D3 per kilogram. Enzyme-linked immunosorbent assay (ELISA) was used to measure the content of 25-(OH)D3 in serum to determine whether vitamin D was deficient.

[0031] After feeding for eight weeks, 3 mice in each group were killed and t...

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Abstract

The invention relates to the field of medicine and discloses application of vitamin D in resisting Aspergillus fumigatus. Compared with the prior art, the invention discloses, for the first time, application of vitamin D in resisting Aspergillus fumigatus; in-vivo experiments show that vitamin D can inhibit activity of conidia of Aspergillus fumigatus and decrease the amount of in-vivo Treg cells;in-vitro experiments show that vitamin D can inhibit the formation of autophagic lysosomes so as to resist infection of Aspergillus fumigatus; in-vivo and in-vitro experiments verify that vitamin D can maintain effective autophagy level and the certain amount of Treg cells in early stage of Aspergillus fumigatus removal in lungs so as to prevent damage from excessive autophagy; vitamin D enhancesthe cellular immunity of a host and can, after the infection of Aspergillus fumigatus, adjust autophagy and Treg cells to fight against the infection of Aspergillus fumigatus.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an application of vitamin D in resisting Aspergillus fumigatus. Background technique [0002] Vitamin D is physiologically important in calcium homeostasis and bone health. Vitamin D exerts biological functions through the activation of vitamin D receptor (VDR), which promotes the absorption of calcium in the small intestine and promotes bone calcification. The vitamin D in the human body mainly comes from the skin after sufficient sun exposure, and more specifically, the 7-dehydrocholesterol stored in the skin is converted into vitamin D3 when exposed to ultraviolet light. Vitamin D3 is sent to the liver through the bloodstream and converted to calcifediol. Studies have shown that in the kidney, active 1,25-dihydroxyvitamin D3 (1,25 D3) is produced through the catalysis of 1a hydroxylase. Without sufficient active vitamin D, serum calcium concentrations decrease, leading to osteoporos...

Claims

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Application Information

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IPC IPC(8): A61K31/59A61P31/10A61P37/04
CPCA61K31/59
Inventor 戴京京李红林王兵周武碧葛培兵
Owner NO 1 THE PEOPLES HOSPITAL HUAIAN CITY
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