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Folium picrasmae injection liquid and preparation method thereof

A technology of injection and bitter wood, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of stability and achieve stable quality, long storage time and stability sexual effect

Inactive Publication Date: 2018-03-13
广州市桐晖药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the existing bitterwood injection is processed from extracts, there is a phenomenon of stability in the preservation process of bitterwood injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0068] A preparation method of bitter wood injection, comprising

[0069] Extract bitter wood extract, extract andrographis paniculata extract, extract patchouli extract respectively;

[0070] Dissolving step: dissolving the above-mentioned bitterwood extract, Andrographis paniculata extract, and patchouli extract respectively with water for injection and then mixing to obtain a mixed solution, adding polysorbate-80 to the mixed solution, and stirring evenly to obtain an injection solution;

[0071] Sterilization: Put the above-mentioned injection in a closed sterilization container and sterilize it by hot pressing.

[0072] As a further solution, in the preparation method of the present invention, the following methods are used to extract the bitter wood extract, the Andrographis paniculata extract and the patchouli extract:

[0073] Pulverizing step: pulverizing the dry raw material into powder through a pulverizer and sieving to obtain the raw material powder;

[0074] Et...

Embodiment 1

[0080] A bitter wood injection, containing the following components in every 1000mL bitter wood injection:

[0081] Bitterwood extract 2.0mg / mL;

[0082] Andrographis paniculata extract 3.5mg / mL;

[0083] Patchouli extract 3.8mg / mL;

[0084] Polysorbate-80 5mg / mL;

[0085] The remaining water for injection;

[0086] Its preparation method is as follows:

[0087] Extract bitter wood extract, extract andrographis paniculata extract, extract patchouli extract respectively: grind the dry raw material into powder through a pulverizer and sieve to obtain the raw material powder; respectively add the above raw material powder into the extraction device, add 80% ethanol, heated to reflux to obtain the extract; transfer the above extract to an evaporator, evaporate and concentrate, and recover ethanol at the same time to obtain a paste; the above paste is diluted with ethanol and left to stand overnight, then filtered, and the filtrate is concentrated into Ointment, the ointment i...

Embodiment 2

[0091] A bitter wood injection, containing the following components in every 1000mL bitter wood injection:

[0092] Bitterwood extract 5.3mg / mL;

[0093] Andrographis paniculata extract 1.2mg / mL;

[0094] Patchouli extract 1.5mg / mL;

[0095] Polysorbate-80 5mg / mL;

[0096] The remaining water for injection;

[0097] Its preparation method is as follows:

[0098] Extract bitter wood extract, extract andrographis paniculata extract, extract patchouli extract respectively: grind the dry raw material into powder through a pulverizer and sieve to obtain the raw material powder; respectively add the above raw material powder into the extraction device, add 80% ethanol, heated to reflux to obtain the extract; transfer the above extract to an evaporator, evaporate and concentrate, and recover ethanol at the same time to obtain a paste; the above paste is diluted with ethanol and left to stand overnight, then filtered, and the filtrate is concentrated into Ointment, the ointment i...

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Abstract

The invention discloses folium picrasmae injection liquid and a preparation method thereof. Per 1000mL of folium picrasmae injection liquid is prepared from the following ingredients including 2.0 to5.3mg / mL of folium picrasmae extracts, 1.2 to 3.5mg / mL of common andrographis herb extracts, 1.5 to 3.8mg / mL of pogostemon cablin leaf extracts, 5 to 10mg / mL of polysorbate-80 and the balance of injection water. The invention also provides the preparation method of the folium picrasmae injection liquid. The folium picrasmae injection liquid provided by the invention has the advantages of stable and controllable quality, longer storage time and higher stability.

Description

technical field [0001] The invention belongs to the technical field of injection medicines, and in particular relates to a bitter wood injection and a preparation method thereof. Background technique [0002] Bitterwood (Picrasma quassioides (D.Don) Benn), also known as soil scorpion, bitter bark tree, bitter bile tree, bear bile tree, is a plant of the genus Picrasma quassioides; it is a deciduous shrub or small tree with gray bark. Brown, smooth, with gray lenticels and markings, branchlets green to reddish brown. Leaves alternate, pinnately compound, leaflet ovate or ovate-elliptic, 4-10cm long, 2-4.5cm wide, with sharp apex, irregular blunt serrate edges, pilose along midrib. Bitterwood contains nigakilactone A~N (nigakilactone A~N), azadirachtin C~G (picrasin C~G), bitterwood hemiacetal C~C, bitterwood ketone (nigakinone), methyl bitterwood ketone, Ⅰ~hydroxymethyl~β~carboline (Ⅰ~hydroxymethyl~β~carboline) and other substances. Its main function is to clear away heat ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K36/532A61K36/59A61P11/00A61P31/00A61P31/04A61P1/12
CPCA61K9/08A61K9/0019A61K36/185A61K36/19A61K36/532A61K36/59A61K47/26A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 张彤丽
Owner 广州市桐晖药业有限公司
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