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Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride compound gel

A technology of nisin and cetylpyridinium chloride, which is applied to the active ingredients of fluorine compounds, medical preparations containing active ingredients, and the digestive system to achieve good therapeutic effects, prolong the action time, and prevent and treat oral ulcers

Inactive Publication Date: 2018-03-06
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, nisin has not been used in oral care products, and the use of nisin in mouthwash still needs to be developed and researched

Method used

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  • Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride compound gel
  • Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride compound gel
  • Preparation and application of nisin, cetylpyridinium chloride and sodium fluoride compound gel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: antibacterial experiment

[0016] Experimental strains: Escherichia coli, Staphylococcus aureus, Lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, Streptococcus mutans, Actinobacillus actinomycetes.

[0017] Strain medium: LB plate, CDC anaerobic blood plate, common blood plate and nutrient broth medium.

[0018] Experimental group preparation: Weigh 0.1g nisin and dissolve it in 100ml probiotic gargle blank (amorphous sorbitol, sodium benzoate, RH40 hydrogenated castor oil, propylene glycol, sodium fluoride, spearmint essence, bright blue pigment , purified water), be mixed with 0.1% nisin solution, and obtain 0.01% nisin by dilution; Weigh 0.2g cetylpyridinium chloride and be dissolved in 100ml sodium azulene gargle blank (sodium azulene The blank of the gargle solution is Blank: non-crystalline sorbitol, sodium benzoate, RH40 hydrogenated castor oil, propylene glycol, spearmint essence, ethanol, purified water), configured into 0.2% ...

Embodiment 2

[0037] An antibacterial and anti-inflammatory compound jelly. The raw materials for making the compound jelly are: 0.01% nisin solution, 0.05% cetylpyridinium chloride solution and 0.1% sodium fluoride solution.

Embodiment 3

[0039] An antibacterial and anti-inflammatory compound gel. The raw materials for making the compound gel are: 0.01% nisin solution, 0.05% cetylpyridinium chloride solution, 0.1% sodium fluoride solution and probiotic periodontal care gel blank.

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PUM

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Abstract

The invention discloses preparation and application of nisin, cetylpyridinium chloride and sodium fluoride compound gel and belongs to the technical field of a medicinal preparation. Raw materials ofthe compound gel comprise: 0.01% of nisin, 0.05% of cetylpyridinium chloride (CPC) and 0.1% of sodium fluoride (NaF) and the rest of xanthan gum. The compound gel has important effects in oral medicine. However, safety and wound restoration capability of the compound gel influence the clinical effect. The antibacterial anti-inflammatory compound gel of the invention has an obvious restoration effect on oral ulcer and has safety and the advantage of rapid restoration of oral ulcer wound.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and relates to an antibacterial and anti-inflammatory jelly. Background technique [0002] Oral ulcer is a disease with the highest incidence rate in oral mucosal diseases, and it is prone to occur in lips, cheeks, tongue margins, etc., and seriously affects the quality of life. Moreover, various bacteria such as Streptococcus mutans and Escherichia coli are also closely related to oral ulcers. [0003] Sodium fluoride can inhibit bacteria, effectively prevent dental caries, reduce dental plaque, and has been widely used in oral care products. Cetyl pyridinium chloride is cetyl pyridinium chloride hydrate, which belongs to cationic surfactant. It mainly inhibits or kills bacteria by reducing surface tension and increasing cell permeability. It is currently used as an adjuvant treatment for oral diseases. It can also be used for daily oral care. Due to the inherent physical p...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K9/08A61K47/36A61P1/02A61P29/00A61P31/02A61K31/44A61K33/16
Inventor 龚爱华程洁唐宇韩秀陈曦曾建刘菲许婧
Owner JIANGSU UNIV
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