Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of electroactive anticorrosion coating based on γ-polyglutamic acid and its preparation method

An anti-corrosion coating, polyglutamic acid technology, applied in coatings, electrolytic coatings, etc., can solve the problems of non-degradable conductive polymers, application limitations, tissue inflammation, etc., to maintain biocompatibility and biodegradability , The preparation method is simple, and the effect of increasing the amount of addition

Active Publication Date: 2019-03-22
JIANGNAN UNIV
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the commonly used conductive polymers are not degradable, and their long-term existence in the body will cause tissue inflammation, which limits their application in the field of biomaterials.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of electroactive anticorrosion coating based on γ-polyglutamic acid and its preparation method
  • A kind of electroactive anticorrosion coating based on γ-polyglutamic acid and its preparation method
  • A kind of electroactive anticorrosion coating based on γ-polyglutamic acid and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of electroactive γ-PGA: Weigh 1 mmol γ-PGA and dissolve it in 10 mL dimethyl sulfoxide (DMSO), heat to 70°C and stir to dissolve. After forming a uniform solution, add 1 mmol HOBt and 1 mmol EDC·HCl to activate Carboxyl group, then add 0.2mmol electroactive small molecule aniline tetramer (TANi), react at 50°C for 24h, and then precipitate and centrifuge in ethanol to obtain electroactive γ-PGA-TANi with a modification rate of 10%.

[0023] (2) Preparation of electroactive self-assembled colloidal particle solution: the γ-PGA-TANi prepared in step (1) was dissolved in DMSO to prepare a solution with a concentration of 5 mg / mL, and the alcohol solution was added dropwise under stirring, A stable solution of electroactive colloidal particles is prepared by a selective solvent method. The particles are spherical, with a diameter of 70nm and a charge of -35mV. The morphology and size of the colloidal particles in the dry state are shown in the attached figu...

Embodiment 2

[0026] (1) Preparation of electroactive γ-PGA: Weigh 1 mmol γ-PGA and dissolve it in 10 mL dimethyl sulfoxide (DMSO), heat to 70°C and stir to dissolve. After forming a uniform solution, add 1 mmol HOBt and 1 mmol EDC·HCl to activate Carboxyl group, then add 0.5mmol electroactive small molecule aniline tetramer (TANi), react at 50°C for 24h, and then precipitate and centrifuge in ethanol to obtain electroactive γ-PGA-TANi with a modification rate of 20%.

[0027] (2) Preparation of electroactive self-assembled colloidal particle solution: the γ-PGA-TANi prepared in step (1) was dissolved in DMSO to prepare a solution with a concentration of 8 mg / mL, and the alcohol solution was added dropwise under stirring, A stable solution of electroactive colloidal particles is prepared by a selective solvent method. The particles are spherical, with a diameter of 100nm and a charge of -32mV. The CV curve of colloidal particles is attached figure 2 shown.

[0028] (3) Preparation of ele...

Embodiment 3

[0030] (1) Preparation of electroactive γ-PGA: Weigh 1 mmol γ-PGA and dissolve it in 10 mL dimethyl sulfoxide (DMSO), heat to 70°C and stir to dissolve. After forming a uniform solution, add 1 mmol HOBt and 1 mmol EDC·HCl to activate Carboxyl group, then add 1 mmol of electroactive small molecule aniline tetramer (TANi), react at 50°C for 24h, and then precipitate and centrifuge in ethanol to obtain electroactive γ-PGA-TANi with a modification rate of 27%.

[0031] (2) Preparation of electroactive self-assembled colloidal particle solution: the γ-PGA-TANi prepared in step (1) was dissolved in DMSO to prepare a solution with a concentration of 10 mg / mL, and the alcohol solution was added dropwise under stirring, A stable solution of electroactive colloidal particles is prepared by a selective solvent method. The particles are spherical in shape with a diameter of 120nm and a charge of -28mV.

[0032](3) Preparation of electroactive anticorrosion coating on the surface of magnes...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an electroactivity anti-corrosion coating based on gamma- polyglutamic acid and a preparation method thereof. The electroactivity anti-corrosion coating not only has good anti-corrosion performance, but also can keep the original cell compatibility of base materials. The preparation method comprises the following steps of putting electro-active small molecular aniline tetramer through amidation reaction into natural poly-polypeptide gamma-polyglutamic acid, then carrying out self-assembly in selective solvent, and finally preparing the electro-active anti-corrosion coating on the surface of magnesium alloy through electrophoretic deposition technology. The electroactivity anti-corrosion coating can well adjust and control the degradation behaviors of the magnesiumalloy, and also has lower cytotoxicity and good cell compatibility. In addition, the whole preparation process is simple to operate, low in energy consumption, and wide in application range, and easily realizes industrialization.

Description

technical field [0001] The invention relates to the integration of electroactive small molecules into natural polypeptide chains through chemical reactions, self-assembly to form spherical colloid particles, and finally secondary assembly on the surface of magnesium alloys to form anti-corrosion coatings by electrophoretic deposition technology, which belongs to macromolecule self-assembly and biomedical applications. Polymer and biomedical metal anticorrosion technology field. technical background [0002] At present, the intensification of population aging makes the demand for bone repair materials more extensive. However, stainless steel and titanium alloys commonly used in clinical applications are biologically inert materials, which have problems such as non-degradability, stress shielding, and release of toxic ions, which increase the pain and burden of patients. However, magnesium and magnesium alloys can effectively solve these problems, and are called "green engine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C25D15/00
CPCC25D15/00
Inventor 刘晓亚崔燕朱叶孙家娣孟龙顾瑶
Owner JIANGNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com