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Patellar scaffold and preparation method thereof

A patella and scaffold model technology, applied in the field of biomedical tissue engineering, can solve problems such as failure of patella replacement, and achieve the effect of maintaining mechanical and mechanical properties, good biocompatibility and curative effect, good biocompatibility and mechanical and mechanical properties

Inactive Publication Date: 2018-11-27
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: patellar fractures, dislocations, knee extensor device breakage, osteonecrosis are more frequent in total knee arthroplasty with patellar replacement than in total knee arthroplasty without patellar replacement, and patellar prosthesis wear , loosening and patellar snapping and other unique complications of patella replacement, these complications can directly lead to the failure of patella replacement

Method used

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  • Patellar scaffold and preparation method thereof
  • Patellar scaffold and preparation method thereof
  • Patellar scaffold and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) According to the mass ratio of Mg 93.32%, Zn 5.23%, Zr 0.34%, Ti 0.11%, the purity is above 99.9% and the particle size is 60-80μm atomized spherical metal powder of Mg, Zn, Zr and Ti Mix, add foaming agent MgH with a particle size of 0.2-0.35mm 2 , The magnesium alloy mixture is obtained after uniform mixing, and dried; the addition amount of the blowing agent is 45% of the mass of the magnesium alloy mixture;

[0046] (2) Obtain the rabbit patella, scan its microstructure with micro CT, and use the 3D reconstruction software Mimics to reconstruct the patella structure; import the patella shape STL file into Mimics for Boolean operation to generate the patella scaffold model; in the patellar scaffold model The hole diameter of the stent is 0.1mm, and the porosity of the hole is 60%. Export the patella stent entity STL file for processing;

[0047] (3) Import the three-dimensional model data of the patella obtained in step (2) into the rapid prototyping machine. Under th...

Embodiment 2

[0049] (1) According to the mass ratio of Mg 93.32%, Zn 5.23%, Zr 0.34%, Ti 0.11%, the purity is above 99.9% and the particle size is 60-80μm atomized spherical metal powder of Mg, Zn, Zr and Ti Mixing, adding magnesium sulfate, a pore-forming agent with a particle size of 0.2-0.35 mm, mixing uniformly to obtain a magnesium alloy mixture, and drying it; the addition amount of the foaming agent is 60% of the mass of the magnesium alloy mixture;

[0050] (2) Obtain the rabbit patella, scan its microstructure with micro CT, and use the 3D reconstruction software Mimics to reconstruct the patella structure; import the patella shape STL file into Mimics for Boolean operation to generate the patella scaffold model; in the patellar scaffold model The hole diameter of the scaffold is 0.25mm, and the porosity of the hole is 30%. Export the patella scaffold entity STL file for processing;

[0051] (3) Import the three-dimensional model data of the patella obtained in step (2) into the rapid ...

Embodiment 3

[0053] (1) According to the mass ratio of Mg 94.32%, Zn 5.18%, Zr 0.35%, Ti 0.15%, the purity is above 99.9% and the particle size is 60-80μm atomized spherical metal powder of Mg, Zn, Zr and Ti Mixing, adding magnesium sulfate, a pore-forming agent with a particle size of 0.2-0.35mm, mixing uniformly to obtain a magnesium alloy mixture, and drying it; the added amount of the foaming agent is 40% of the mass of the magnesium alloy mixture;

[0054] (2) Obtain the rabbit patella, scan its microstructure with micro CT, and use the 3D reconstruction software Mimics to reconstruct the patella structure; import the patella shape STL file into Mimics for Boolean operation to generate the patella scaffold model; in the patellar scaffold model The hole diameter of the scaffold is 0.4mm, and the porosity of the hole is 50%. Export the patella scaffold entity STL file for processing;

[0055] (3) Import the three-dimensional model data of the patella obtained in step (2) into the rapid proto...

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Abstract

The invention relates to a patellar scaffold and a preparation method thereof. The patellar scaffold is made of magnesium alloy and comprises, by mass, 93-95% of Mg, 5-5.5% of Zn, 0.2-0.4% of Zr, and0.1-0.3% of Ti. Patellar structure is extracted by means of three-dimensional reconstruction to construct a patellar scaffold model; the specific magnesium alloy formulation is used as a raw materialto prepare the magnesium alloy patellar scaffold, having the advantages of good mechanical properties, in-vivo degradability, good biocompatibility, good bio-durability and the like. The need for bonereplacement for fractures, dislocations, osteonecrosis and the like in practical application is satisfied; the problems are solved that, for instance, original protheses mismatch with biological anatomical features, debris of the protheses causes harm, and the embedded implants are unable to degrade; the patellar scaffold has a good application prospect.

Description

Technical field [0001] The invention relates to the field of biomedical tissue engineering, in particular to a patella scaffold and a preparation method thereof. Background technique [0002] Magnesium alloy is currently the lightest metal structural material in engineering applications, with a density of 1.74g / cm3, which is about 2 / 3 of aluminum alloy, 2 / 5 of titanium alloy, 1 / 5 of nickel alloy, and 1 / 4 of steel. And it has high specific strength and specific rigidity, which is an ideal matrix for lightweight porous metal materials. Because the density and mechanical properties of magnesium alloy and human compact bone are relatively close, and it has good biocompatibility and degradability, it is a potential biomedical material with good application prospects, so it is made of magnesium and magnesium alloy Porous metals will give full play to the advantages of porous metals and magnesium alloys and broaden the application fields of magnesium alloys. Studies have found that po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/50A61L27/56A61F2/38C22C23/04B22F3/11
CPCA61F2/3877A61F2002/2835A61F2310/00041A61L27/047A61L27/50A61L27/56A61L2430/02B22F3/1125C22C23/04
Inventor 尚鹏张琴丽侯增涛杨朝岚徐大众刘嘉徐榕
Owner SHENZHEN INST OF ADVANCED TECH
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