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Oral sublingual product applicable to urticaria and preparation method thereof

A technology for urticaria and products, applied in the field of oral oral products for urticaria and preparation thereof, can solve the problems of intractable urticaria side effects, gastrointestinal discomfort, hair loss and the like

Inactive Publication Date: 2018-02-23
中山市择朋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Immunosuppressants have obvious side effects, and even have certain risks. Long-term use can lead to bone marrow suppression, liver function damage, hair loss, hemorrhagic cystitis, gastrointestinal discomfort, etc.
[0004] The advantage of western medicine in treating urticaria is quick effect, but it is difficult to cure urticaria and has relatively large side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. No. 1 oral product for urticaria

[0041] Prepare stock solution:

[0042] (1) Preparation of liquid medium: Add 20 g of magnesium sulfate, 50 g of dipotassium hydrogen phosphate, 50 g of potassium dihydrogen phosphate, 250 g of sucrose, and 250 g of starch into 18 L of hydrogen-rich water, and then add hydrogen-rich water to make up to 20 L.

[0043] (2) Inject the liquid culture medium into 500ml glass bottles, each bottle is 400ml, and a total of 50 bottles are obtained, and put them into a portable pressure cooker at 0.012MP / cm 2 , 30min, take it out, cool it to 28°C-34°C, put it into a clean bench, and prepare a liquid medium.

[0044] (3) Put the tools, utensils and liquid medium into the ultra-clean workbench, put 30g of potassium permanganate into a vessel containing 30ml of 50% formalin, and use hooks, rakes, needles, and knives for inoculation Put it into the container and sterilize it for 30min.

[0045] (4) Cut the mother black fungus test tube...

Embodiment 2

[0056] Embodiment 2. No. 2 oral preparations for urticaria

[0057] Prepare the mother seed solution: the steps are the same as in Example 1.

[0058] Raw materials with good ratio: 2 fresh round-leaf perilla leaves, 5 fresh long-leaved perilla leaves, and 5 fresh serrated perilla leaves.

[0059] Step 1. Hydrogen-rich water (Hitian Tianling water) is inactivated in an ultra-high pressure cooker at 30°C and 600mpa for 10 minutes. After completion, 50 liters of it are injected into a sterile fermenter through a sterile silica gel pipeline for later use.

[0060] Step 2. Prepare the water extract of the bulk drug:

[0061] The well-proportioned raw materials are packed in a 100-mesh filter, and the hydrogen-rich water and the well-proportioned raw materials are added to the ultra-high pressure cooker. The weight ratio of the hydrogen-rich water to the raw materials is 4:1;

[0062] Treat at 25° C. and 600 mpa for 20 minutes to obtain a water extract of the bulk drug.

[0063]...

Embodiment 3

[0067] Embodiment 3. No. 3 oral preparations for urticaria

[0068] Prepare the mother seed solution: the steps are the same as in Example 1.

[0069] Raw materials with good ratio: 5 fresh round perilla leaves, 2 fresh long perilla leaves, and 4 fresh serrated perilla leaves.

[0070] Step 1. Hydrogen-rich water (Hita Tianling water) is inactivated in an ultra-high pressure cooker at 30°C and 600mpa for 10 minutes. After completion, 45 liters of it are injected into a sterile fermenter through a sterile silica gel pipeline for later use.

[0071] Step 2. Prepare the water extract of the bulk drug:

[0072] The well-proportioned raw materials are packed in a 100-mesh filter, and the hydrogen-rich water and the well-proportioned raw materials are added to the ultra-high pressure cooker. The weight ratio of the hydrogen-rich water to the raw materials is 4:3;

[0073] Treat at 35° C. and 600 mpa for 10 minutes to obtain a water extract of the bulk drug.

[0074] Step 3. Co-fe...

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PUM

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Abstract

The invention relates to traditional Chinese medicine products and processing technologies thereof, specifically to an oral sublingual product applicable to urticaria and a preparation method thereof.The oral sublingual product comprises a component A, wherein the component A is the product prepared by co-fermenting water extracting liquid of raw material medicines and auricularia auricula-judaemother strain liquid; the raw material medicines, in parts by weight, include 2-5 parts of fresh round-leaf folia perillae acutae, 2-5 parts of fresh long-leaf folia perillae acutae, and 2-5 parts offresh serrated folia perillae acutae. The oral sublingual product is capable of recovering autoimmune function of a human body, thus achieving the effect of treating both symptoms and root causes of urticaria; the product is free from side effect, and low in relapse possibility after healing.

Description

technical field [0001] The invention relates to a traditional Chinese medicine product and its processing technology, in particular to an oral product for urticaria and a preparation method thereof. Background technique [0002] Urticaria, commonly known as wheal or wheal, is a common skin disease in clinical practice. It is a localized edema reaction caused by the dilation and increased permeability of small blood vessels in the skin and mucous membrane. The onset is rapid, usually within 2 to 24 hours. Regression, but new rash occurs repeatedly, and the course of the disease lasts for several days to several months. The cause of disease of urticaria is very complicated, and about 3 / 4 patient can't find reason, especially chronic urticaria. Common causes mainly include: food and food additives, inhalation, infection, drugs, physical factors such as mechanical stimulation, heat and cold, sunlight, etc., insect bites, mental factors and endocrine changes, genetic factors, et...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/535A61P17/00
CPCA61K9/0056A61K36/07A61K36/535A61K2236/19A61K2236/331A61K2236/53A61K2300/00
Inventor 彭鹏李泽文郑永琴彭都
Owner 中山市择朋生物科技有限公司
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