Nasal douche for treating chronic nasosinusitis and preparation method thereof

A technology of chronic sinusitis and nasal wash, which is applied in the field of nasal wash for the treatment of chronic sinusitis and its preparation, can solve the problems of lack of Chinese patent medicine nasal wash formulations for chronic sinusitis, and achieve the elimination of mucosal swelling and edema, safety High sex, relieve nasal congestion

Inactive Publication Date: 2018-02-09
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is still a lack of effective Chinese patent medicine nasal wash formulations for the treatment of chronic sinusitis in clinical practice. Therefore, it is necessary to strengthen its pharmaceutical research on the basis of nasal irrigation prescriptions with definite clinical curative effects to form a unified new medicine. Product development plan to provide better market circulation varieties

Method used

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  • Nasal douche for treating chronic nasosinusitis and preparation method thereof
  • Nasal douche for treating chronic nasosinusitis and preparation method thereof
  • Nasal douche for treating chronic nasosinusitis and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0043] The preparation method of any one of the above-mentioned nasal washes for the treatment of chronic sinusitis, comprising the following steps:

[0044] 1) Weigh each raw material according to any of the above-mentioned formulas, and set aside;

[0045] 2) adding water to extract the traditional Chinese medicine composition twice, collecting the distillate A, filtering, combining the filtrates, concentrating under reduced pressure, and concentrating to a clear paste B with a relative density of 1.10-1.15;

[0046] 3) Add ethanol to clear cream A after cooling until the alcohol content is 63-67% v / v, let stand, take supernatant, recover ethanol, concentrate to clear cream C with a relative density of 1.18-1.22, and cool for later use;

[0047] 4) Take distillate A, add co-solvent, dissolve and mix well, then add preservative, dissolve and mix well, then add clear paste C, mix well, then add acid-base regulator to make the pH value 4.5-7.5, add water to the desired Need vo...

Embodiment 1

[0050] Embodiment 1 A kind of nasal wash for the treatment of chronic sinusitis

[0051] Recipe composition:

[0052]

[0053] Preparation:

[0054] (1) take medicinal material raw material by formula, standby;

[0055] (2) Take the raw materials of the above-mentioned ten medicinal materials, add water to extract twice, add 8 times of water for the first time, collect distillate A of twice the weight of the medicinal materials, extract for 1.5 hours, add 5 times of water for the second time, and extract for 1.5 hours, Filtrate, combine the filtrates, concentrate under reduced pressure, and concentrate to clear cream B with a relative density of 1.10-1.15 (60°C);

[0056] (3) Clear cream A is allowed to cool, add 95% ethanol until the alcohol content is 65%, let stand at room temperature for 24 hours, take the supernatant, recover ethanol, and concentrate to clear cream C with a relative density of 1.18-1.22 (60°C) , let it cool for later use;

[0057] (4) Get the disti...

Embodiment 2

[0058] Embodiment 2 A kind of nasal wash for the treatment of chronic sinusitis

[0059] Recipe composition:

[0060]

[0061]

[0062] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a nasal douche for treating chronic nasosinusitis and a preparation method thereof. The nasal douche is prepared from radix astragali seu hedysari, cassia twig, epimedium herb,biond magnolia flower, lemonfragrant angelica root, cape jasmine fruit, wild chrysanthemum flower, Szechuan lovage rhizome, herba menthae and radix angelicae sinensis. The nasal douche disclosed by the invention directly targets focuses when externally applied, and the active ingredients flow into the nasal cavity and the paranasal sinuses under pressure to dilute thick secretion in the nasal cavity, promote the drainage of the secretion, soften scabs and eliminate mucous membrane swellings and edemas, thus effectively alleviating the symptoms of nasosinusitis, such as nasal obstruction, rhinorrhea and poor sense of smell, promoting the absorption of the medicine and increasing the effect of local treatment; after washing, liquor is kept in the sinus cavities, and can persistently play arole, improving the pathogenesis of lung-spleen Qi deficiency of the chronic nasosinusitis from the outside to the inside; the nasal douche disclosed by the invention is a clinical empirical formula,and is clinically applied for years, the therapeutic effect is obvious, safety is high, and the nasal douche can fill the gap of safe and effective Chinese patent medicines for washing the nasal cavity in the pharmaceutical market at present.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a nasal wash for treating chronic sinusitis and a preparation method thereof. Background technique [0002] Modern medicine has confirmed that chronic rhinosinusitis (CRS, formerly known as chronic sinusitis) refers to at least two of the following clinical symptoms caused by the inflammatory response of the nasal and sinus mucosa, such as nasal congestion, runny nose (front or rear nostrils), Forehead and (or) facial pain or distending pain, and hyposmia or loss of sense of smell, among which nasal congestion or runny nose is one of the essential symptoms. In addition to the above typical symptoms, the patient must also have the following signs: ① Nasal endoscopy found (one or more of the following): nasal polyps or nasal mucosal polypoid changes; middle nasal passage mucopurulent discharge; edema or swelling of the tract mucosa; ②CT examination results...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/08A61P11/02
CPCA61K9/0043A61K9/08A61K36/232A61K36/236A61K36/287A61K36/296A61K36/481A61K36/534A61K36/54A61K36/575A61K36/744A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 阮岩何伟平王建慧
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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