Production method of mexiletine hydrochloride
A technology of mexiletine hydrochloride and a production method, applied in the production field of mexiletine hydrochloride, can solve the problems of removal of difficult mixtures, difficulty in recovery and purification, and high price, and achieves the effects of increasing production rate, reducing production cost, and less resource consumption
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0043] Etherification step: put 122 parts of 2,6-dimethylphenol and 366 parts of 1,2-dichloroethane into the reactor, add 61 parts of potassium carbonate, 3 parts of sodium bromide, 16 parts of tetrabutyl bromide ammonium chloride, the temperature was raised to reflux, and a mixed solution of 40 parts of 1,2-dichloroethane and 80 parts of chloroacetone was added dropwise, and the reflux reaction was continued for 2 hours after dropping. The solid residue was filtered off, and 1,2-dichloroethane was recovered to obtain 170 parts of ether ketone.
[0044] Amination reduction step: put 170 parts of sperm ketone, 385 parts of 10% ammonia methanol, and 6 parts of Raney nickel into the hydrogenation kettle, feed hydrogen into the kettle to 1.2MPa, raise the temperature to 100°C, keep warm and keep the hydrogen pressure at 1.2 MPa, until the end of hydrogen absorption, the temperature is lowered to below 30°C, the catalyst is removed by sedimentation, and the ammonia methanol is reco...
Embodiment 2
[0047] Etherification step: Put 120 parts of 2,6-dimethylphenol and 360 parts of 1,2-dichloroethane into the reaction kettle, add 200 parts of potassium bicarbonate, 2 parts of potassium iodide, and 10 parts of tetrabutylammonium bromide , the temperature was raised to reflux, and a mixed solution of 600 parts of 1,2-dichloroethane and 70 parts of chloroacetone was added dropwise, and the reflux reaction was continued for 2 hours after dropping. The solid residue was filtered off, and 1,2-dichloroethane was recovered to obtain 170 parts of ether ketone.
[0048] Amination reduction step: put 170 parts of sperm ketone, 342 parts of 10% ammonia methanol, and 11.4 parts of Raney nickel into the hydrogenation kettle, feed hydrogen into the kettle to 1.2MPa, raise the temperature to 100°C, keep warm and keep the hydrogen pressure at 1.2 MPa, until the end of hydrogen absorption, the temperature is lowered to below 30°C, the catalyst is removed by sedimentation, and the ammonia meth...
Embodiment 3
[0051] Etherification step: Put 130 parts of 2,6-dimethylphenol and 370 parts of 1,2-dichloroethane into the reactor, add 80 parts of potassium carbonate, 5 parts of sodium bromide, 20 parts of tetrabutyl bromide ammonium, the temperature was raised to reflux, and a mixed solution of 40 parts of 1,2-dichloroethane and 90 parts of chloroacetone was added dropwise, and the reflux reaction was continued for 2 hours after dropping. The solid residue was filtered off, and 1,2-dichloroethane was recovered to obtain 175 parts of ether ketone.
[0052] Amination reduction step: Put 175 parts of sperm ketone, 405 parts of 10% ammonia methanol, and 7 parts of Raney nickel into the hydrogenation kettle, feed hydrogen into the kettle to 1.2MPa, raise the temperature to 100°C, keep warm and keep the hydrogen pressure at 1.2 MPa, until the hydrogen absorption is completed, the temperature is lowered to below 30°C, the catalyst is removed by sedimentation, and the ammonia methanol is recover...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com