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Release rate rapid regulating child febrifuge ibuprofen produced by pressurizing coating method

A technology for antipyretics and children, which can be used in antipyretics, pharmaceutical formulas, drug combinations, etc., and can solve problems such as no relevant research

Inactive Publication Date: 2018-01-19
锡山区东港全宝机械经营部
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant research on the ropivacaine sustained-release drug delivery system using MBG as the carrier.

Method used

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  • Release rate rapid regulating child febrifuge ibuprofen produced by pressurizing coating method

Examples

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Embodiment Construction

[0018] Step 1: Preparation of SiO2 colloidal crystal template

[0019] Preparation of monodisperse SiO2 microspheres: Monodisperse SiO2 microsphere suspensions were prepared by an alkaline hydrolysis process of ethyl orthosilicate (TEOS) using Stöber's method. Weigh 251.2 g of absolute ethanol, 118.25 g of deionized water and 34 g of NH3·H2O into a conical flask, mix well under magnetic stirring, add 27.7 g of TEOS, and continue magnetic stirring for 3 h to obtain a suspension of SiO2 particles liquid.

[0020] Preparation of SiO2 colloidal crystal template: firstly, the suspension of SiO2 particles prepared above is removed by rotary evaporation to remove excess solvent, then placed in a flat-bottomed container, and centrifuged to remove excess solvent to form a large disordered SiO2 colloid crystal template, and then sintered at a high temperature of 1000 ° C to obtain a SiO2 colloidal crystal template.

[0021] Step 2: Preparation of Inverse Colloidal Carbon Template

[...

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Abstract

The invention relates to a pressurizing vibrating coating process for child febrifuge ibuprofen, which is characterized by comprising the following steps: 1: drying and air-drying nano glass microsphere powder loading the ibuprofen into powder for later use; and 2: uniformly dispersing the powder, tiling on a flat, bright and clean round plane with sufficient surface intensity, of which the periphery is provided with an enclosure, then pressing another flat, bright and clean round surface which is sufficient in hardness on the nano glass microsphere powder loading the ibuprofen to carry out pre-pressurizing, then carrying out vibration, pressurizing to a required pressure while vibrating, then dropwise adding high-molecular polymer solution around the powder to a wet state, and at a normaltemperature, keeping ventilation until finishing volatilization, wherein the two round planes have equal areas, and the upper surface is embedded into the enclosure of the lower surface.

Description

technical field [0001] The invention relates to children's antipyretic ibuprofen which is produced by a pressurized wrapping method and whose release speed is quickly adjusted. Background technique [0002] Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in the treatment of rheumatism and rheumatoid arthritis. [0003] Indicated for the treatment of mild to moderate migraine episodes, migraine prevention, chronic episodic hemigraine, exertion and menstrual headaches, rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylosis Inflammation and neuritis etc. [0004] Small-sized monodisperse drug-loaded mesoporous bioactive glass microspheres (MBGMs) / ethylene glycol...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/51A61K47/02A61K47/10A61K47/34A61K31/192A61P29/00
Inventor 王全宝
Owner 锡山区东港全宝机械经营部
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