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Madecassoside liposomal gel for local external application and preparation method thereof

The technology of madecassoside and liposome gel is applied in the field of pharmaceutical preparations and skin care products, which can solve the problems of increased skin dosage, strong fluidity, waste of drugs, etc., so as to be beneficial to wound healing without irritation. Effect, good fit effect

Inactive Publication Date: 2018-01-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When liposome solution is used to treat skin wounds, because of its strong fluidity, it is easy to lose, resulting in a waste of medicine, thereby increasing the amount of skin medication

Method used

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  • Madecassoside liposomal gel for local external application and preparation method thereof
  • Madecassoside liposomal gel for local external application and preparation method thereof
  • Madecassoside liposomal gel for local external application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044](1) Preparation of madecassoside liposome solution: weigh 0.50 g of egg yolk lecithin, 0.10 g of cholesterol, and 0.1 g of VE acetate and dissolve it in 10 mL of dichloromethane to prepare an organic solution; remove the organic solvent by rotary evaporation To form a film, add 20 mg / mL madecassoside solution into the film, add an appropriate amount of glass beads and stir at 50°C for 1 hour, sonicate with a probe for 30 minutes, and pass through a 0.22 μm water-based filter membrane to obtain a madecassoside liposome solution. In the madecassoside liposome solution, the mass of madecassoside accounts for 22.22%, and the mass of egg yolk lecithin accounts for 55.56%.

[0045] (2) Preparation of blank gel: add 0.1 g of azone and 1.5 g of propylene glycol in 8 mL of water, and then add 0.2 g of sodium carboxymethyl cellulose, and stir thoroughly to obtain a blank gel.

[0046] (3) Add 2 mL of madecassoside liposome solution in step (1) to the blank gel in step (2), stir we...

Embodiment 2

[0049] (1) Preparation of madecassoside liposome solution: Weigh 0.50 g of egg yolk lecithin, 0.10 g of cholesterol, and 0.1 g of VE acetate and dissolve it in 10 mL of ethanol to prepare an organic phase solution; Add dropwise into 15 mg / mL madecassoside solution, stir while adding dropwise until the solvent is removed, and pass through a 0.22 μm oily filter membrane to obtain madecassoside liposome solution. In the madecassoside liposome solution, the mass of madecassoside accounts for 17.65%, and the mass of egg yolk lecithin accounts for 58.82%.

[0050] (2) Preparation of blank gel: add 0.1 g of azone and 2.0 g of propylene glycol in 7.5 mL of water, and then add 0.4 g of sodium carboxymethylcellulose, and stir thoroughly to obtain a blank gel.

[0051] (3) Add 2.5mL madecassoside liposome solution in step (1) to the blank gel in step (2), adjust the pH value to 7 with 7% NaOH solution to obtain madecassoside plastid gel. The madecassoside liposome average particle diam...

Embodiment 3

[0054] (1) Preparation of madecassoside liposome solution: weigh 0.50 g of egg yolk lecithin, 0.10 g of cholesterol, and 0.1 g of VE acetate and dissolve it in 10 mL of dichloromethane to prepare an organic solution; remove the organic solvent by rotary evaporation To form a film, add 10mg / mL madecassoside solution into the film, rotate and hydrate to obtain a liposome solution, add 0.005g mannitol, mix well, freeze-dry in vacuum, shake the liposome freeze-dried powder with PBS Shake to disperse to obtain madecassoside liposome solution. In the madecassoside liposome solution, the mass of madecassoside accounts for 12.42%, and the mass of egg yolk lecithin accounts for 62.11%.

[0055] (2) Preparation of blank gel: add 0.1 g of azone and 1.8 g of propylene glycol in 7 mL of water, and then add 0.6 g of sodium carboxymethylcellulose, and stir thoroughly to obtain a blank gel.

[0056] (3) Add 2 mL of madecassoside liposome solution in step (1) to the blank gel in step (2), adj...

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Abstract

The invention discloses a madecassoside liposomal gel for local external application and a preparation method thereof. The liposomal gel is mainly prepared from a madecassoside liposomal, a gel and ultrapure water, wherein the liposomal is provided with a bilayer structure; madecassoside is encapsulated into the liposomal; the mass of the madecassoside liposomal accounts for 1 to 60 percent of thetotal mass of the liposomal gel, and the mass of the gel accounts for 1 to 30 percent of the total mass of the liposomal gel. The liposomal gel has the characteristic of a semi-solid gel state, the drug has a better fitting effect on a wound, the administration time is ensured, a better drug delayed release effect is achieved, a better antisepsis and anti-inflammation effect is achieved, and themadecassoside liposomal gel is beneficial for healing the wound and has no stimulation on skins so as to be high efficient and safe; the liposomal can be promoted to effectively permeate through the skins, so that more madecassoside components can stay in a corium layer, and a drug effect is more remarkable. The madecassoside liposomal gel can be used as an excellent slow release preparation for repairing scars and promoting wound healing.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and skin care products, and in particular relates to a locally applied madecassoside liposome gel, a preparation method thereof and an application in treating scars. Background technique [0002] Madecassoside is one of the main triterpenoid saponins in Centella asiatica (L.) Urban. Madecassoside has a wide range of pharmacological activities such as anti-inflammation, anti-oxidation, and promotion of wound healing. It is used to treat skin injuries, burns and scalds, and repair scars. Due to the characteristics of its polar macromolecules, madecassoside is difficult to directly penetrate the stratum corneum and epidermis of the skin. [0003] Liposomes are cell membrane-like spherical bodies composed of phospholipid bilayers. The interior of the liposome can encapsulate various fat-soluble or water-soluble drugs, thereby improving the stability and utilization of the drug. Liposomes ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/127A61K31/7024A61K47/38A61K47/36A61P17/02A61K8/63A61K8/14A61K8/04A61Q19/00
Inventor 刘美凤鄢豪曾嘉达
Owner SOUTH CHINA UNIV OF TECH
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