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Medical thermo-sensitive hydrogel dressing and preparation method thereof

A temperature-sensitive hydrogel and hydrogel technology, used in medical science, bandages, absorbent pads, etc., can solve the problems of intractable wounds, obvious foreign body sensation, no antibacterial properties, etc., and achieve good antibacterial repair effect. , Not easy to secondary damage, strong plasticity effect

Inactive Publication Date: 2016-02-03
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sterile gauze is easy to adhere to the wound, which often damages the new epithelial and granulation tissue when changing the dressing, and the patient suffers from unbearable pain.
At the same time, the sterile gauze itself has no antibacterial properties, and in the wound care, the patient often sweats, and the gauze shifts due to moisture in the adhesive tape, which needs to be replaced repeatedly. Too many closed adhesive tapes can easily cause skin allergies, itching, and blisters; when the temperature is low (such as winter), the adhesive tape has poor viscosity, and it is not easy to effectively seal the wound and other problems
These problems make the wound prone to infection
[0003] Existing wound dressings, such as medical gauze, sponge, etc., are basically in a solid form, and there are many problems in the process of use, such as poor adhesion to the wound, easy infection of the wound, obvious foreign body sensation, and irregular wounds are difficult to treat and easy to treat. Inherent defects of solid form dressings such as causing secondary injury

Method used

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  • Medical thermo-sensitive hydrogel dressing and preparation method thereof
  • Medical thermo-sensitive hydrogel dressing and preparation method thereof
  • Medical thermo-sensitive hydrogel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A medical temperature-sensitive hydrogel dressing, comprising the following raw material components in percentage by weight:

[0019]

[0020] The balance is water.

[0021] A preparation method of a medical thermosensitive hydrogel dressing, comprising the following steps: weighing 1% of acetic acid, 2% of chitosan and 6% of hydroxypropyl methylcellulose in the percentage by weight of raw materials, adding 30.5% by weight of water, stirring and dissolving in a water bath at 70-90°C for 10-20 minutes, cooling and stirring in an ice-water bath to prepare a viscous solution, taking 0.5% by weight of raw materials and adding sodium carbonate to the viscous The solution is stirred while being added to make the pH of the viscous solution 6.5-7.5, defoaming, and after standing still, continue to add glycerin which accounts for 60% by weight of the raw material and stir evenly to obtain a hydrogel dressing.

Embodiment 2

[0023] A medical temperature-sensitive hydrogel dressing, comprising the following raw material components in percentage by weight:

[0024]

[0025] The balance is water.

[0026] A preparation method of a medical temperature-sensitive hydrogel dressing, comprising the following steps: taking 2% acetic acid, 3% chitosan and 9% hydroxypropyl methylcellulose in weight percent of raw materials, adding 35% by weight of water, stirring and dissolving in a water bath at 70-90°C for 10-20 minutes, cooling and stirring in an ice-water bath to prepare a viscous solution, taking 1% by weight of raw materials and adding sodium carbonate to the viscous solution In the solution, the viscous solution has a pH value of 6.5-7.5, defoaming, and after standing still, continue to add glycerin which accounts for 50% by weight of raw materials and stir evenly to obtain a hydrogel dressing.

Embodiment 3

[0028] A medical temperature-sensitive hydrogel dressing, comprising the following raw material components in percentage by weight:

[0029]

[0030] The balance is water.

[0031] A preparation method of a medical thermosensitive hydrogel dressing, comprising the following steps: weighing 1% of acetic acid, 2% of chitosan and 6% of hydroxypropyl methylcellulose in the percentage by weight of raw materials, adding 26.5% by weight of water, stirring and dissolving in a water bath at 70-90°C for 10-20 minutes, cooling and stirring in an ice-water bath to prepare a viscous solution, taking 0.5% by weight of raw materials and adding sodium carbonate to the viscous solution, stirring while adding, so that the pH of the viscous solution is 6.5-7.5, defoaming, after standing still, continue to add glycerin, 2% collagen hyaluronic acid, 1% Vitamin E and 1% phenoxyethanol were stirred evenly to obtain a hydrogel dressing.

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Abstract

The invention belongs to the technical field of medical products, and particularly relates to a medical thermo-sensitive hydrogel dressing and a preparation method thereof. The medical thermo-sensitive hydrogel dressing comprises the following raw materials by weight: 2 to 3 percent of chitosan, 6 to 9 percent of hydroxypropyl methyl cellulose, 50 to 60 percent of glycerin, 1 to 2 percent of acetic acid, 0.5 to 1 percent of sodium carbonate, and the balance of water. The medical thermo-sensitive hydrogel dressing is liquid in storage state at room temperature, can cover a whole wound surface in a spraying manner and then jellify, and is high in plasticity and fitting property, similar to skin in modulus of elasticity, low in secondary harm possibility, suitable for trauma wounds of any shape and various types, and excellent in bacterium resisting and repairing effects on the wounds.

Description

technical field [0001] The invention belongs to the technical field of medical products, and in particular relates to a medical temperature-sensitive hydrogel dressing and a preparation method thereof. Background technique [0002] Wound healing is a complex process, which is affected by many factors, such as infection, wound pollution, autoimmunity, etc. Among them, infection is the most common factor, and infection is the main reason affecting wound healing. Therefore, it is very necessary to create a good environment for wound healing and prevent wound infection. Currently, local external application of "antibacterial drugs" and "dressings" are used for clinical treatment. "Antibacterial drugs" lead to more and more serious clinical drug resistance problems and "dressings" have no clear antibacterial effect, which makes wounds prone to infection, slow healing and scar formation. Traditional medicine clinically treats various skin injuries such as burns, wounds, scalds an...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L26/00
Inventor 汪涛陈丽慢吴大洋
Owner SOUTHWEST UNIVERSITY
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