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A biomedical degradable corrosion-resistant high-strength magnesium alloy and its preparation method

A biomedical and magnesium alloy technology, applied in medical science, surgery, etc., can solve the problems of unfavorable alloy biocompatibility, harsh storage and smelting conditions, high price, etc., and achieve good comprehensive mechanical properties and blood compatibility. , the effect of reducing the corrosion rate

Active Publication Date: 2019-05-21
BEIJING AMSINO MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the disadvantage of this magnesium alloy is that the content of the heavy rare earth element Gd in the composition is relatively high (≥5%), and the Gd element is considered to be a toxic element, which is not conducive to improving the biocompatibility of the alloy.
In addition, the magnesium alloy contains expensive Ag elements, and the preservation and smelting conditions are relatively harsh, thereby increasing the cost

Method used

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  • A biomedical degradable corrosion-resistant high-strength magnesium alloy and its preparation method
  • A biomedical degradable corrosion-resistant high-strength magnesium alloy and its preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0038] This embodiment provides a biomedical degradable corrosion-resistant high-strength magnesium alloy. Based on the total weight of the magnesium alloy as 100%, its composition is: Nd 1.5%, Zn 0.4%, Ca 0.4%, Zr 0.4% and Mg balance.

[0039] The magnesium alloy is prepared through the following steps:

[0040] (1) In a vacuum smelting furnace, the pure magnesium with a purity of 99.99wt.% or more, the pure Zn with a purity of 99.99wt.% or more, the pure Ca with a purity of 99.99wt.% or more, and the middle of Mg-30wt.% Nd are melted sequentially Alloy, Mg-30wt.% Zr intermediate alloy, control the temperature of the alloy melt to be 740-760°C when melting. After all the raw materials are melted, argon gas is introduced to carry out gas stirring in a vacuum environment, and the stirring time is 40 min.

[0041] (2) Pass SF to the surface of the melt after stirring 6 with CO 2 Mixed gas (SF in the mixed gas 6 :CO 2 The volume ratio is 1:100) for protection, and at the sa...

Embodiment 2

[0047] This embodiment provides a biomedical degradable corrosion-resistant high-strength magnesium alloy. Based on the total weight of the magnesium alloy as 100%, its composition is: Nd 2.0%, Zn 0.6%, Ca 0.5%, Zr 0.6% and Mg balance.

[0048] The magnesium alloy is prepared through the following steps:

[0049] (1) In a vacuum smelting furnace, the pure magnesium with a purity of 99.99wt.% or more, the pure Zn with a purity of 99.99wt.% or more, the pure Ca with a purity of 99.99wt.% or more, and the middle of Mg-30wt.% Nd are melted sequentially Alloy, Mg-30wt.% Zr intermediate alloy, control the temperature of the alloy melt to be 740-760°C when melting. After all the raw materials are melted, argon gas is introduced to carry out gas stirring in a vacuum environment, and the stirring time is 40 min.

[0050] (2) Pass SF to the surface of the melt after stirring 6 with CO 2 Mixed gas (SF in the mixed gas 6 :CO 2 The volume ratio is 1:100) for protection, and at the sa...

Embodiment 3

[0056] This embodiment provides a biomedical degradable corrosion-resistant high-strength magnesium alloy. Based on the total weight of the magnesium alloy as 100%, its composition is: Nd 2.5%, Zn 0.8%, Ca 0.6%, Zr 0.8% and Mg balance.

[0057] The magnesium alloy is prepared through the following steps:

[0058] (1) In a vacuum smelting furnace, the pure magnesium with a purity of 99.99wt.% or more, the pure Zn with a purity of 99.99wt.% or more, the pure Ca with a purity of 99.99wt.% or more, and the middle of Mg-30wt.% Nd are melted sequentially Alloy, Mg-30wt.% Zr intermediate alloy, control the temperature of the alloy melt to be 740-760°C when melting. After all the raw materials are melted, argon gas is introduced to carry out gas stirring in a vacuum environment, and the stirring time is 40 min.

[0059] (2) Pass SF to the surface of the melt after stirring 6 with CO 2 Mixed gas (SF in the mixed gas 6 :CO 2 The volume ratio is 1:100) for protection, and at the sa...

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Abstract

The invention provides a biomedical degradable anti-corrosion high strength and ductility magnesium alloy and a preparation method thereof. With the total weight of the magnesium alloy being 100%, thecomponents of the magnesium alloy comprise, by weight, 1.0-4.5% of Nd, 0.2-2.0% of Zn, 0-1.0% of Ca, 0-1.0% of Zr and the balance Mg. The preparation method of the magnesium alloy includes the stepsthat by adopting a mode of vacuum semi-continuous casting, a magnesium alloy cast ingot is prepared according to the components and the weight percentage of the magnesium alloy, then solid solution treatment and extrusion are conducted on the magnesium alloy cast ingot, and the magnesium alloy is prepared. The biomedical degradable anti-corrosion high strength and ductility magnesium alloy has theadvantages of being nontoxic, capable of being degraded completely, good in anti-corrosion property, high in strength and ductility and the like, and can be used for preparing intravascular stents.

Description

technical field [0001] The invention relates to a biomedical degradable corrosion-resistant high-strength magnesium alloy and a preparation method thereof, belonging to the technical field of medical material preparation. Background technique [0002] The vascular stents currently used clinically are mainly made of inert metal materials such as stainless steel, nickel-titanium alloy, and cobalt-chromium alloy. Such stents can provide durable mechanical support for the blood vessels at the lesion when implanted in the human body, and avoid the elastic rebound of the blood vessels. shrinkage, reducing the restenosis rate of blood vessels. However, stents made of inert metal materials cause excessive hyperplasia of the vascular intima after implantation, which not only causes vascular restenosis and late thrombosis, but also requires long-term antiplatelet therapy. In recent years, the application of drug-eluting stents has reduced the restenosis rate of blood vessels to about...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C23/04C22C23/06C22C1/03C22F1/06B22D11/00A61L31/02
Inventor 马国睿马晓意
Owner BEIJING AMSINO MEDICAL
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