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Golden eriodictine-7-o-β-d-glucuronic acid ethyl ester and its extraction method and application

A technology for ethyl glucuronate and esculin, which is applied in the field of esculin-7-O-β-D-ethyl glucuronate and its extraction, can solve the problem of anti-type 2 diabetes active ingredients It can reduce the blood sugar level of alloxan diabetic mice and adrenaline diabetic mice, and achieve the effect of simple and easy extraction method, good hypoglycemic effect and high extraction rate.

Inactive Publication Date: 2020-09-01
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, Triangularia research has attracted widespread attention at home and abroad. The research group has carried out basic research on Triangularia and found that the total ethanol extract of Triangularia can significantly reduce blood sugar in alloxan-induced diabetic mice and adrenaline-induced diabetic mice. Value; fed with high-fat and high-sugar feed combined with intraperitoneal injection of small doses of streptozotocin (STZ) to establish a type 2 diabetes rat model, and determined that the site with the strongest anti-type 2 diabetes activity was n-butanol, but its anti-type 2 diabetes The research on the active ingredients and mechanism of diabetes mellitus is quite shallow

Method used

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  • Golden eriodictine-7-o-β-d-glucuronic acid ethyl ester and its extraction method and application
  • Golden eriodictine-7-o-β-d-glucuronic acid ethyl ester and its extraction method and application
  • Golden eriodictine-7-o-β-d-glucuronic acid ethyl ester and its extraction method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of aureotin-7-O-beta-D-glucuronide ethyl ester, the structural formula of the aureotin-7-O-beta-D-glucuronate ethyl ester is:

[0029]

[0030] A method for extracting erionthyrin-7-O-β-D-glucuronide ethyl ester, comprising the following steps:

[0031] 1) using triangular bubble coarse powder as raw material, ethanol as solvent, adopting percolation method to extract, reclaiming ethanol solvent, and obtaining the first extract;

[0032] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0033] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0034] 4) Take the third extract...

Embodiment 2

[0041] A kind of aureotin-7-O-beta-D-glucuronide ethyl ester, the structural formula of the aureotin-7-O-beta-D-glucuronate ethyl ester is:

[0042]

[0043] A method for extracting erionthyrin-7-O-β-D-glucuronide ethyl ester, comprising the following steps:

[0044] 1) using triangular bubble coarse powder as raw material, ethanol as solvent, adopting percolation method to extract, reclaiming ethanol solvent, and obtaining the first extract;

[0045] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0046] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0047]4) Take the third extract,...

Embodiment 3

[0054] A kind of aureotin-7-O-beta-D-glucuronide ethyl ester, the structural formula of the aureotin-7-O-beta-D-glucuronate ethyl ester is:

[0055]

[0056] A method for extracting erionthyrin-7-O-β-D-glucuronide ethyl ester, comprising the following steps:

[0057] 1) using triangular bubble coarse powder as raw material, ethanol as solvent, adopting percolation method to extract, reclaiming ethanol solvent, and obtaining the first extract;

[0058] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0059] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0060] 4) Take the third extract...

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Abstract

The invention discloses a chrysoeriol-7-O-beta-D-ethyl glucuronate. The structural formula of the chrysoeriol-7-O-beta-D-ethyl glucuronate is A. The invention also discloses an extraction method of the chrysoeriol-7-O-beta-D-ethyl glucuronate and application of the chrysoeriol-7-O-beta-D-ethyl glucuronate to preparing antioxidant drugs, antioxidant cosmetics, hypoglycemic drugs and anti-tumor drugs.

Description

technical field [0001] The present invention relates to a compound and its extraction method and use. More specifically, the present invention relates to a golden eriodictine-7-O-β-D-glucuronic acid ethyl ester and its extraction method and use. Background technique [0002] Sanjiaopao is the dry whole herb of Sapindaceae Cardiospermum halicacabum L., also known as false balsam pear and sailboat. Mainly distributed in Guangdong, Guangxi, Fujian, Taiwan and other places, its taste is pungent and cold, and has the effects of clearing away heat, diuresis, cooling blood, removing blood stasis, and detoxifying. It is mostly used to treat pneumonia, jaundice, gonorrhea, furuncle, rheumatism, and trauma Injuries, snake bites and other diseases. Modern pharmacological studies have shown that triangular bubbles have anti-inflammatory, anti-oxidant, analgesic, antipyretic, anti-malarial, anti-diarrheal, diuretic, anti-diabetic, anti-convulsant, and anti-anxiety effects. In recent y...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P17/18A61P3/10A61P35/00A61K8/60A61Q19/08
CPCA61K8/602A61Q19/08C07H1/08C07H17/07
Inventor 韦建华卢汝梅李兵王柳萍陈睿陈明伟
Owner GUANGXI UNIV OF CHINESE MEDICINE
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