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Hydrogel for preventing postoperative adhesion of abdominal cavity as well as preparation method and application of hydrogel

A technology of hydrogel and peritoneal cavity, which is applied in the field of hydrogel and its preparation to prevent postoperative adhesions after abdominal surgery. It can solve the problems of fibrin immunogenicity risk, difficulty in using surgical laparoscopy, and limited effectiveness. Inhibits the invasion of fibroblasts, prevents the occurrence of adhesions, and promotes healing

Active Publication Date: 2017-12-29
上海鹏冠生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above two types of anti-adhesion products have certain shortcomings in clinical practice: Interceed, a film-based anti-adhesion product, has limited effectiveness when there is blood and peritoneal fluid; Speprafilm has strict requirements in open surgery, and it is difficult to use laparoscopy ;Surgiwrap needs to be sutured or fixed, and there is a risk of re-adhesion; the solution-based anti-adhesion product Adept has poor adhesion and the abdominal cavity will expand; Sepracoat rapidly erodes, and its effectiveness is limited
The fibrin used by Evicel has the risk of immunogenicity

Method used

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  • Hydrogel for preventing postoperative adhesion of abdominal cavity as well as preparation method and application of hydrogel
  • Hydrogel for preventing postoperative adhesion of abdominal cavity as well as preparation method and application of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] All animals were fasted without food and water for 12 hours; they were anesthetized by intraperitoneal injection of chloral hydrate. After successful anesthesia, the rats were fixed supine on the operating board, the abdomen was depilated, routinely disinfected, sterile towels were spread, and the central position of the abdomen was removed to create an incision. For the cecum, find and take out the terminal position of the small intestine, select the position above the terminal end of the small intestine, place it on sterile gauze, and stuff it back into the cecum to dry the serosa, gently scrape the surface of the ileum membrane with a scalpel blade, and then drop absolute ethanol on the wound surface , and then grasp the mesenteric artery with toothless forceps, causing temporary ischemia. In the control group, anti-adhesion materials were not applied to the operation area, and the ileocecal gyrus was brought into the original position of the abdominal cavity, and the...

Embodiment 2

[0031] Take calcium chloride 4 wt%, sodium alginate (1.2 wt%) / sodium carboxymethyl cellulose (2 wt%) as an example (37°C, G' / G'' : 1600 / 500 Pa / Pa, n : 1700 Pa S), weighed 2.4 g sodium alginate and 4 g sodium carboxymethyl cellulose, respectively dissolved in 100 ml deionized water to obtain 100 ml sodium alginate solution and 100 ml sodium carboxymethyl cellulose solution, and Mix 100ml of sodium alginate solution and 100ml of sodium carboxymethylcellulose solution, and magnetically stir until uniform to obtain 200ml of compound solution c, and add 5ml of 4wt% calcium chloride solution (cationic aqueous solution d) dropwise into compound solution c , made into a hydrogel. After standing at room temperature for 1 h, put them in the upper layer of the refrigerator to refrigerate for later use (experimental group 1).

[0032] All animals were fasted without food and water for 12 hours; they were anesthetized by intraperitoneal injection of chloral hydrate. After successful an...

Embodiment 3

[0034] Take calcium chloride 4 wt%, sodium alginate (1.2 wt%) / sodium carboxymethyl cellulose (2 wt%) as an example (37°C, G' / G'' : 1600 / 500 Pa / Pa, n : 1700 Pa S), weighed 2.4 g sodium alginate and 4 g sodium carboxymethyl cellulose, respectively dissolved in 100 ml deionized water to obtain 100 ml sodium alginate solution and 100 ml sodium carboxymethyl cellulose solution, and Mix 100ml of sodium alginate solution and 100ml of sodium carboxymethylcellulose solution, and magnetically stir until uniform to obtain 200ml of compound solution c, and add 5ml of 4wt% calcium chloride solution (cationic aqueous solution d) dropwise into compound solution c , made into a hydrogel. After standing at room temperature for 1 h, put them in the upper layer of the refrigerator to refrigerate for later use (experimental group 1).

[0035] All animals were fasted without food and water for 12 hours; they were anesthetized by intraperitoneal injection of chloral hydrate. After successful ...

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Abstract

The invention discloses hydrogel for preventing postoperative adhesion of an abdominal cavity. The hydrogel is prepared from the following components in parts by weight: sodium alginate, oxidized sodium alginate, sodium carboxymethyl cellulose and sodium hydroxymethyl cellulose. The molecular weight of the sodium alginate is as follows: Mw is equal to 2*10<4> to 4*10<4>; the molecular weight of the oxidized sodium alginate is as follows: Mw is equal to 5*10<3> to 2*10<4>. According to the hydrogel prepared by the invention, the hydrogel is attached on surfaces of tissues by adopting an injection or coating manner. High-hydrophilicity and high-charge-density natural macromolecular materials including the sodium alginate, the oxidized sodium alginate, the sodium carboxymethyl cellulose and the sodium hydroxymethyl cellulose and the like, which are not compatible with cells, are complexed and crossed through cations to obtain a hydrogel network. According to the product disclosed by the invention, the postoperative fibrous adhesion is avoided by utilizing high hydrophilicity and high charge density in a manner of preventing fibroblasts from being invaded and preventing tissue contact. The product has the remarkable advantages of suitable corrosion and degradation speed, no immunogenicity, relatively good adhesive force, reduction of bacterium infection, promotion of healing effect and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a hydrogel for preventing adhesion after abdominal surgery, a preparation method and application thereof. Background technique [0002] After surgery, tissue adhesion is a common clinical phenomenon in the field of surgery, and it is also a process that patients must go through during the rehabilitation process. Adhesions are abnormal structures formed by fibrous bands of connective tissue joining together with adjacent tissues or organs. According to statistics, the annual cost of treating abdominal and pelvic adhesions is as high as 1.2 billion US dollars. At present, the treatment measures to prevent postoperative adhesion formation mainly focus on two aspects: (1) drug therapy: use the anti-inflammatory effect of drugs to inhibit the proliferation of fibroblasts, reduce the secretion of collagen fibers and accelerate their dissolution; (2) physical barrier : ...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14
CPCA61L31/128A61L31/145A61L31/148C08L1/286C08L5/04
Inventor 朱宏彬洪跟东李月艳
Owner 上海鹏冠生物医药科技有限公司
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