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Golden eriodictine-7-o-β-d-butyl glucuronate and its extraction method and use

A technology of golden erioflavin and butyl aldehyde, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problem of reducing blood sugar levels in alloxan-induced diabetic mice and adrenergic diabetic mice , anti-type 2 diabetes active ingredients and other problems, to achieve the extraction method is simple and easy, good blood sugar lowering effect, the effect of high extraction rate

Inactive Publication Date: 2020-06-16
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, Triangularia research has attracted widespread attention at home and abroad. The research group has carried out basic research on Triangularia and found that the total ethanol extract of Triangularia can significantly reduce blood sugar in alloxan-induced diabetic mice and adrenaline-induced diabetic mice. Value; fed with high-fat and high-sugar feed combined with intraperitoneal injection of small doses of streptozotocin (STZ) to establish a type 2 diabetes rat model, and determined that the site with the strongest anti-type 2 diabetes activity was n-butanol, but its anti-type 2 diabetes The research on the active ingredients and mechanism of diabetes mellitus is quite shallow

Method used

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  • Golden eriodictine-7-o-β-d-butyl glucuronate and its extraction method and use
  • Golden eriodictine-7-o-β-d-butyl glucuronate and its extraction method and use
  • Golden eriodictine-7-o-β-d-butyl glucuronate and its extraction method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of aureotin-7-O-beta-D-glucuronide butyl ester, the structural formula of the aureotidin-7-O-beta-D-glucuronate butyl ester is:

[0030]

[0031] A method for extracting erionthydin-7-O-β-D-butyl glucuronate, comprising the following steps:

[0032] 1) using triangular bubble coarse powder as raw material, ethanol as solvent, adopting percolation method to extract, distilling ethanol solvent to obtain the first extract;

[0033] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0034] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0035] 4) Take the third extract, carry o...

Embodiment 2

[0043] A kind of aureotin-7-O-beta-D-glucuronide butyl ester, the structural formula of the aureotidin-7-O-beta-D-glucuronate butyl ester is:

[0044]

[0045] A method for extracting erionthydin-7-O-β-D-butyl glucuronate, comprising the following steps:

[0046] 1) using triangular bubble coarse powder as raw material, ethanol as solvent, adopting percolation method to extract, distilling ethanol solvent to obtain the first extract;

[0047]2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0048] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0049] 4) Take the third extract, carry ou...

Embodiment 3

[0057] A kind of aureotin-7-O-beta-D-glucuronide butyl ester, the structural formula of the aureotidin-7-O-beta-D-glucuronate butyl ester is:

[0058]

[0059] A method for extracting erionthydin-7-O-β-D-butyl glucuronate, comprising the following steps:

[0060] 1) using triangular bubble coarse powder as raw material, ethanol as solvent, adopting percolation method to extract, distilling ethanol solvent to obtain the first extract;

[0061] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0062] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0063] 4) Take the third extract, carry o...

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Abstract

The invention discloses chrysoeriol-7-O-beta-D-butyl glucuronate. The structural formula of the chrysoeriol-7-O-beta-D-butyl glucuronate is shown in the description. The invention also discloses an extraction method of the chrysoeriol-7-O-beta-D-butyl glucuronate and application of the chrysoeriol-7-O-beta-D-butyl glucuronate in preparation of antioxidant drugs, antioxidant cosmetics, hypoglycemic drugs or anti-tumor drugs.

Description

technical field [0001] The present invention relates to a compound and its extraction method and use. More specifically, the present invention relates to a golden eriodictine-7-O-β-D-butyl glucuronate and its extraction method and use. Background technique [0002] Sanjiaopao is the dry whole herb of Sapindaceae Cardiospermum halicacabum L., also known as false balsam pear and sailboat. Mainly distributed in Guangdong, Guangxi, Fujian, Taiwan and other places, its taste is pungent and cold, and has the effects of clearing away heat, diuresis, cooling blood, removing blood stasis, and detoxifying. It is mostly used to treat pneumonia, jaundice, gonorrhea, furuncle, rheumatism, and trauma Injuries, snake bites and other diseases. Modern pharmacological studies have shown that triangular bubbles have anti-inflammatory, anti-oxidant, analgesic, antipyretic, anti-malarial, anti-diarrheal, diuretic, anti-diabetic, anti-convulsant, and anti-anxiety effects. In recent years, Tria...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08A61K8/60A61Q19/08A61P3/10A61P35/00A61P39/06
CPCA61K8/602A61Q19/08C07H1/08C07H17/07
Inventor 韦建华卢汝梅卢澄生廖彭莹霍丽妮曾艳婷
Owner GUANGXI UNIV OF CHINESE MEDICINE
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