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Tryptanthrin-platinum complex, and synthesis method and application thereof

A technology of tryptamine platinum and a synthesis method, which is applied in the field of medicine, can solve the problem that the research of tryptanone and platinum complex has not yet been reported, and achieves the effects of good medicinal value, low cost and easy control of reaction conditions.

Active Publication Date: 2017-12-19
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some tryptanthrin derivatives have been developed for the research of anti-tumor drugs, but the study of tryptanthrin and platinum complexes has not been reported. Therefore, better research ideas and research methods are still needed

Method used

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  • Tryptanthrin-platinum complex, and synthesis method and application thereof
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  • Tryptanthrin-platinum complex, and synthesis method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Weigh tryptanthrin (0.025g, 0.1mmol), Pt(DMSO) 2 Cl 2 (0.060g, 0.15mmol), respectively dissolved in 5ml of chloroform and 5ml of methanol, mixed and placed in a 50ml round bottom flask, reacted for 3 hours under the condition of heating in a water bath at 55°C to make it completely reacted. Filtrate, volatilize at room temperature to obtain red blocky crystals, wash with petroleum ether and chloroform, and dry to obtain tryptanthrin platinum complex with a yield of 86.8%.

[0024] Product detection: the above-mentioned obtained red solid product is subjected to infrared spectrum, nuclear magnetic resonance spectrum, and X-ray single crystal diffraction analysis respectively, such as Figure 1~2 shown, where figure 1 It is the infrared spectrogram of tryptanthrin platinum complex of the present invention; figure 2 It is the X-ray single crystal diffraction structure diagram of the platinum complex of tryptanthrin in the present invention.

[0025] figure 1 Specific...

Embodiment 2

[0051] Weigh tryptanthrin (2.5g, 10mmol), Pt(DMSO) 2 Cl 2(6.0g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, reacted for 3 hours under the condition of heating in a water bath at 55°C to make it completely reacted. Filtrate, volatilize at room temperature to obtain red blocky crystals, wash with petroleum ether and chloroform, and dry to obtain tryptanthrin platinum complex with a yield of 85.8%.

[0052] The product detection method is the same as in Example 1.

Embodiment 3

[0054] Weigh tryptanthrin (2.5g, 10mmol), Pt(DMSO) 2 Cl 2 (6.0g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, reacted for 6 hours under the condition of heating in a water bath at 65°C to make it completely reacted. Filtrate, volatilize at room temperature to obtain red blocky crystals, wash with petroleum ether and chloroform, and dry to obtain tryptanthrin platinum complex with a yield of 85.9%.

[0055] The product detection method is the same as in Example 1.

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Abstract

The invention discloses a tryptanthrin-platinum complex, and a synthesis method and an application thereof, and belongs to the technical field of medicines, and aims at providing a tryptanthrin-platinum complex, a synthesis method thereof, and a new use of the tryptanthrin-platinum complex in the antitumor field. The structural formula of the tryptanthrin-platinum complex is shown in the description, and the tryptanthrin-platinum complex is used for preparing antitumor medicines.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a tryptanthrin platinum complex and its synthesis method and application. Background technique [0002] The ligand selection of the present invention is derived from tryptanthrin (Tryptanthrin), an effective component of the traditional Chinese medicine Radix isatidis alkaloid. Since the successful clinical use of cisplatin anti-tumor metal drugs, the research on platinum complexes has attracted more and more attention. However, due to the toxic side effects and drug resistance of platinum complexes, it has been found Platinum complexes with antitumor activity have always been a research hotspot in this field. Tryptanthrin is derived from the natural plant traditional Chinese medicine Radix Isatidis, which is one of the antibacterial and antiviral active components of Radix Radix. The structure of tryptanthrin has well-coordinated nitrogen atoms and oxygen atoms and a hyperconj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00A61P35/00
CPCC07F15/0093
Inventor 谭明雄覃其品黄国保
Owner YULIN NORMAL UNIVERSITY
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