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Hemostatic sponge/drug-loaded fiber mat/hemostatic sponge compound and preparation method thereof

A technology of hemostatic sponge and fiber felt, applied in the field of hemostatic sponge/medicine-loaded fiber felt/hemostatic sponge composite and its preparation

Inactive Publication Date: 2017-12-15
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Local therapy and hemostasis are simultaneous and necessary in tumor resection surgery, but few studies have combined the two

Method used

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  • Hemostatic sponge/drug-loaded fiber mat/hemostatic sponge compound and preparation method thereof
  • Hemostatic sponge/drug-loaded fiber mat/hemostatic sponge compound and preparation method thereof
  • Hemostatic sponge/drug-loaded fiber mat/hemostatic sponge compound and preparation method thereof

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preparation example Construction

[0027] The present invention also provides a preparation method of a hemostatic sponge / medicated fiber felt / hemostatic sponge composite, the method comprising:

[0028] Step 1: preparing a mixed solution of polymer carrier and antitumor drug, and preparing the mixed solution by electrospinning to obtain a drug-loaded fiber mat;

[0029] Step 2: dissolving the hemostatic sponge material in a solvent to obtain a hemostatic sponge solution, adding a cross-linking agent to the hemostatic sponge solution to obtain a hemostatic sponge precursor solution;

[0030] Step 3: Place the hemostatic sponge precursor solution obtained in step 2 in the mold, and after placing it for 30-40 minutes, place the drug-loaded fiber mat obtained in step 1 on the hemostatic sponge precursor solution, then add the hemostatic sponge precursor solution, and let it stand for a while. After 12-14 hours, the product is freeze-dried to obtain a hemostatic sponge / drug-loaded fiber mat / hemostatic sponge compos...

Embodiment 1

[0043] Dissolve 320mg of PLGA in 3ml of trifluoroethanol, add 80mg of gelatin to 1ml of trifluoroethanol, stir in a water bath at 50°C until completely dissolved, disperse 21.53mg of cisplatin in 500μl of trifluoroethanol, and slowly add it dropwise to the PLGA solution, Stir until uniformly mixed to obtain a mixed solution of PLGA and cisplatin, mix the gelatin solution with the mixed solution of PLGA and cisplatin, stir at room temperature for 2 hours, and use the resulting mixed solution for spinning.

[0044] The resulting spinning solution is immediately spun, and the electrospinning operation parameters involved are as follows: the diameter of the spinneret is 0.4mm, the strength of the applied electrostatic field is 30KV, and the distance between the spinneret and the receiving screen The flow rate of the solution was 1ml / h, and the spinning was all carried out at room temperature to obtain a drug-loaded fiber mat, which was vacuum-dried at 25°C.

[0045] Chitosan was d...

Embodiment 2

[0053] Dissolve 240mg of PCL in 3ml of trifluoroacetic acid, add 80mg of collagen into 1ml of trifluoroacetic acid, stir until completely dissolved, mix the PCL solution and collagen solution evenly, dissolve 16mg of paclitaxel in 500μl of trifluoroacetic acid, then slowly It was added dropwise to the mixed solution of PCL and collagen, stirred at room temperature for 2.5 hours, and the obtained mixed solution was used for spinning.

[0054] The obtained spinning solution is immediately spun, and the electrospinning operation parameters involved are as follows: the diameter of the spinneret is 0.5mm, the strength of the applied electrostatic field is 20KV, the distance between the spinneret and the receiving screen The flow rate of the solution was 0.8ml / h, and the spinning was all carried out at room temperature to obtain a drug-loaded fiber mat, which was vacuum-dried at 25°C.

[0055] Dissolving chitosan in 0.7% acetic acid solution to obtain a chitosan solution with a conc...

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Abstract

The invention provides a hemostatic sponge / drug-loaded fiber mat / hemostatic sponge compound and a preparation method thereof, and belongs to the technical field of polymeric medical materials. The compound has a three-layer sandwich structure, and comprises two hemostatic sponges and a drug-loaded fiber mat arranged between the two hemostatic sponges. The invention also provides the preparation method of the hemostatic sponge / drug-loaded fiber mat / hemostatic sponge compound. The drug-loaded fiber mat is completely wrapped with the hemostatic sponges, the three layers are structurally closely connected and have no gaps, the hemostatic sponges have an obvious three-dimensional network structure, and apertures are connected, so the hemostasis function and the postoperative recurrence prevention function are realized.

Description

technical field [0001] The invention belongs to the technical field of polymer medical materials, and in particular relates to a composite of hemostatic sponge / medicine-loaded fiber felt / hemostatic sponge and a preparation method thereof. Background technique [0002] Surgical resection is the most important means of tumor treatment, but the recurrence rate after surgery is high, and the long-term treatment effect is not satisfactory. Studies have shown that even if the tumor is removed by wedge surgery, 39% of patients still have tumor cells remaining in the tumor site, which proves that the in situ recurrence caused by residual tumor cells is the most important reason for tumor recurrence. Systemic chemotherapy can be used to prevent recurrence after surgery, but the effect is not significant. Intravenous injection of chemotherapeutic drugs accumulates less in the tumor resection site and can cause serious side effects, so it is difficult to achieve a balance between ther...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/20A61L15/42A61L15/44A61K33/24A61K31/337A61K31/704A61K9/00A61K47/34A61K47/42A61P35/00D04H1/728
CPCA61K9/0002A61K9/0092A61K31/337A61K31/704A61K33/24A61K47/34A61K47/42A61L15/20A61L15/28A61L15/325A61L15/42A61L15/425A61L15/44A61L2300/416A61L2300/418A61L2300/602A61L2400/04D04H1/728C08L5/08C08L3/08C08L5/04
Inventor 黄宇彬周东方张志云邝改真李晓媛景遐斌
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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