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Chrysoeriol-7-O-beta-D glucuronic acid methyl ester and extraction method and application thereof

A technology of golden elycoprine and methyl aldol, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problem of shallow anti-type 2 diabetes active ingredients and reduce alloxan-induced diabetes in mice. and epinephrine diabetic mice blood sugar level, etc., to achieve the effect of simple and easy extraction method, good hypoglycemic effect and high extraction rate

Inactive Publication Date: 2017-12-08
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, Triangularia research has attracted widespread attention at home and abroad. The research group has carried out basic research on Triangularia and found that the total ethanol extract of Triangularia can significantly reduce blood sugar in alloxan-induced diabetic mice and adrenaline-induced diabetic mice. Value; fed with high-fat and high-sugar feed combined with intraperitoneal injection of small doses of streptozotocin (STZ) to establish a type 2 diabetes rat model, and determined that the site with the strongest anti-type 2 diabetes activity was n-butanol, but its anti-type 2 diabetes The research on the active ingredients and mechanism of diabetes mellitus is quite shallow

Method used

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  • Chrysoeriol-7-O-beta-D glucuronic acid methyl ester and extraction method and application thereof
  • Chrysoeriol-7-O-beta-D glucuronic acid methyl ester and extraction method and application thereof
  • Chrysoeriol-7-O-beta-D glucuronic acid methyl ester and extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of aureotidin-7-O-β-D-glucuronide methyl ester, the structural formula of the aureotidin-7-O-β-D-glucuronate methyl ester is:

[0029]

[0030] A method for extracting erionthydin-7-O-β-D-glucuronide methyl ester, comprising the following steps:

[0031] 1) using triangular foam coarse powder as raw material and ethanol as solvent, extracting by percolation method to obtain ethanol extract, reclaiming ethanol solvent to obtain the first extract;

[0032] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0033] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0034] 4) Take ...

Embodiment 2

[0041] A kind of aureotidin-7-O-β-D-glucuronide methyl ester, the structural formula of the aureotidin-7-O-β-D-glucuronate methyl ester is:

[0042]

[0043] A method for extracting erionthydin-7-O-β-D-glucuronide methyl ester, comprising the following steps:

[0044] 1) using triangular foam coarse powder as raw material and ethanol as solvent, extracting by percolation method to obtain ethanol extract, reclaiming ethanol solvent to obtain the first extract;

[0045] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0046] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0047]4) Take t...

Embodiment 3

[0054] A kind of aureotidin-7-O-β-D-glucuronide methyl ester, the structural formula of the aureotidin-7-O-β-D-glucuronate methyl ester is:

[0055]

[0056] A method for extracting erionthydin-7-O-β-D-glucuronide methyl ester, comprising the following steps:

[0057] 1) using triangular foam coarse powder as raw material and ethanol as solvent, extracting by percolation method to obtain ethanol extract, reclaiming ethanol solvent to obtain the first extract;

[0058] 2) Add water to the first extract to form a suspension, add sherwood oil, ethyl acetate, and n-butanol to the suspension in turn for extraction, concentrate the n-butanol extract to form an extract, and use it as the second extract ;

[0059] 3) Take the second extract, carry out polyamide column chromatographic separation, use water-ethanol as eluent, carry out gradient elution, collect 50% ethanol water eluate, concentrate 50% ethanol water eluate to obtain Extract, as the third extract;

[0060] 4) Take ...

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Abstract

The invention discloses a chrysoeriol-7-O-beta-D glucuronic acid methyl ester. The structural formula of the chrysoeriol-7-O-beta-D glucuronic acid methyl ester is disclosed in the following diagram. The invention also discloses an extraction method for the chrysoeriol-7-O-beta-D glucuronic acid methyl ester and the application of the chrysoeriol-7-O-beta-D glucuronic acid methyl ester for preparing antioxidant medicines, antioxidant cosmetics, hypoglycemic drugs or antitumor drugs.

Description

technical field [0001] The present invention relates to a compound and its extraction method and use. More specifically, the present invention relates to a golden eriodictine-7-O-β-D-glucuronic acid methyl ester and its extraction method and use. Background technique [0002] Sanjiaopao is the dry whole herb of Sapindaceae Cardiospermum halicacabum L., also known as false balsam pear and sailboat. Mainly distributed in Guangdong, Guangxi, Fujian, Taiwan and other places, its taste is pungent and cold, and has the effects of clearing away heat, diuresis, cooling blood, removing blood stasis, and detoxifying. It is mostly used to treat pneumonia, jaundice, gonorrhea, furuncle, rheumatism, and trauma Injuries, snake bites and other diseases. Modern pharmacological studies have shown that triangular bubbles have anti-inflammatory, anti-oxidant, analgesic, antipyretic, anti-malarial, anti-diarrheal, diuretic, anti-diabetic, anti-convulsant, and anti-anxiety effects. In recent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K8/60A61P39/06A61P3/10A61P35/00A61Q19/08
CPCA61K8/602A61Q19/08C07H1/08C07H17/07
Inventor 卢汝梅韦建华李兵朱小勇黄志其曾艳婷
Owner GUANGXI UNIV OF CHINESE MEDICINE
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