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Method for continuous countercurrent ultrasonic extracting of coenzyme Q10

A countercurrent ultrasonic and coenzyme technology, applied in organic chemistry, quinone separation/purification, etc., can solve the problems of inability to reduce the amount of solvent, labor intensity, and extraction time. The effect of the leaching effect

Inactive Publication Date: 2017-12-08
INNER MONGOLIA KINGDOMWAY PHARMA LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ultrasonic extraction technology accelerates the penetration, dissolution, and diffusion during the extraction process, shortens the extraction time, and improves the extraction yield. However, if the tank-type ultrasonic extraction equipment is used, the extraction scale is small, and the second is that it cannot be continuous. At the same time, because there is no concentration difference, The extraction is not clean once, and multiple extractions are required, which can neither reduce the amount of solvent nor reduce the labor intensity, and the problems of slag discharge in conventional extraction tanks still exist. Except for the short time, there are no other obvious advantages

Method used

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  • Method for continuous countercurrent ultrasonic extracting of coenzyme Q10
  • Method for continuous countercurrent ultrasonic extracting of coenzyme Q10
  • Method for continuous countercurrent ultrasonic extracting of coenzyme Q10

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 8

[0076] Example 8 Coenzyme Q10 Extraction

[0077] Get the fermentation thalline 1000kg of Rhodobacter sphaeroides, drop in with the feeding speed of 200kg / h from the feed inlet of continuous countercurrent ultrasonic extraction machine one end by screw feeding device, extraction solvent (10% ethyl acetate-90% n-heptane ) from the solvent inlet at the other end (the side close to the slag outlet) through the flowmeter at a feed rate of 1600L / h, and the bacteria slowly propelled toward the slag outlet under the action of the screw propeller, while the solvent It flows in the opposite direction of the cell movement, and the cell and the solvent fully contact in this countercurrent movement, thereby extracting the coenzyme Q10 in the cell. During the continuous countercurrent extraction process, the ultrasonic vibrator is turned on at the same time for auxiliary extraction, the ultrasonic frequency is 60KHZ, and the extraction temperature is controlled at 15°C. The extract is dis...

Embodiment 2

[0099] Embodiment 2 adopts the technical scheme of continuous countercurrent ultrasonic extraction of a low-polarity single solvent system, compared with Example 10, the extraction yield of Example 10 is obviously better than that of Example 2, indicating that the use of a mixed solvent system helps to improve the coenzyme Q10 The extraction yield;

[0100] Embodiments 6 and 9 adopt the technical scheme of continuous countercurrent ultrasonic extraction of a highly polar single solvent system, in contrast to Example 11, the content of coenzyme Q10 in the extract obtained in Example 11 is significantly higher than that of Examples 6 and 9, indicating that The use of a mixed solvent system helps to improve the quality of the extract of coenzyme Q10.

[0101] In summary, the technical solution of the present invention has the advantages of high extraction efficiency, high extraction rate of active ingredients, and small liquid output coefficient (the ratio of the input extraction...

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Abstract

The invention discloses a method for continuous countercurrent ultrasonic extracting of coenzyme Q10. The method comprises the following steps: respectively feeding thalli and an extraction solvent into a digestion cabin from the feeding ports at the two ends of a continuous countercurrent ultrasonic extracting machine, making the thalli and extraction solvent flow reversely and meanwhile starting an ultrasonic oscillator for assisting in extraction; evaporating and concentrating the extracting solution; purifying, thereby acquiring coenzyme Q10; recovering the solvent; performing residue and liquid separation on the extracted thalli, mixing the extracting solution with the extracting solution acquired in the last step and concentrating, drying and desolventizing the wet thalli residue, thereby acquiring dry thalli residue and recovering the solvent; recovering the gas generated in the processing process through a solvent tail gas recovering system and condensing, thereby acquiring the recovered solvent; and re-pouring all the recovered solvent into a solvent storage tank for recycling. According to the extracting method disclosed by the invention, the continuous dynamic countercurrent ultrasonic extraction is realized within a shorter extracting pipe, the gradient ratio is guaranteed, the yield is increased, the solvent dosage is reduced, the output of later filtering, separation and concentration is relieved, the energy is saved, the consumption is reduced and the production cost is lowered.

Description

technical field [0001] The invention belongs to the field of extraction of coenzyme Q10, in particular to a method for continuous countercurrent ultrasonic extraction of coenzyme Q10. Background technique [0002] Coenzyme Q10, English name Coenzyme Q10, referred to as CoQ10. It is a vitamin-like substance widely distributed in the human body, especially in the heart with the highest content. It is the only natural nutrient on the market that has the functions of activating cellular respiration and anti-free radical oxidation. It is a powerful antioxidant when used alone or in combination with vitamin E. As a metabolic activator, it exists in the mitochondrial inner membrane of cells and generates cellular power through specific cellular metabolism. At the same time, it is also a vitamin-like nutrient substance. After consumption, it can activate cellular respiration, accelerate the production of high-energy ATP, strengthen myocardial metabolism, and improve heart beating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C46/10C07C50/06
CPCC07C46/10C07C50/06
Inventor 王炳荣廖炜程焉世杰游煌崔柏苓
Owner INNER MONGOLIA KINGDOMWAY PHARMA LTD
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