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Mesoporous silicon nano particles having properties of stimulation response and split-warehouse intelligent drug carrying and release and preparation method of mesoporous silicon nano particles

A stimuli-response, nanoparticle technology, applied in the field of nanomaterials, can solve problems such as side reactions, affecting curative effect, etc., and achieve the effects of low cost, convenient operation and simple device

Inactive Publication Date: 2017-12-01
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since most of the current drugs are loaded on micelles, mesoporous silicon and other carriers after mixing, drugs with different biochemical activities may interact with each other due to pre-mixing, which affects the curative effect.
What's more, the synergistic toxic effects between different drugs may cause unexpected side effects during the delivery process after drug blending

Method used

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  • Mesoporous silicon nano particles having properties of stimulation response and split-warehouse intelligent drug carrying and release and preparation method of mesoporous silicon nano particles
  • Mesoporous silicon nano particles having properties of stimulation response and split-warehouse intelligent drug carrying and release and preparation method of mesoporous silicon nano particles
  • Mesoporous silicon nano particles having properties of stimulation response and split-warehouse intelligent drug carrying and release and preparation method of mesoporous silicon nano particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Preparation of mesoporous silicon nanoparticles with stimuli-responsive and intelligent drug-loading and drug-releasing properties, the steps are as follows:

[0047] 1) Preparation of mesoporous silicon nanoparticles: Dissolve 0.5gCTAB and 0.015gNaOH in 480mL deionized water and stir vigorously, then heat to 80°C, stir evenly to obtain a mixed solution, and then slowly drop 2.5gTEOS into the above mixed solution , the dropping speed is 10d / min, and the reaction is carried out under vigorous stirring at 80°C for 2h, and centrifuged (8000r / min, 10min) to obtain a white solid, which is washed several times with secondary water and methanol, and vacuum-dried to obtain a white solid with a surface MCM-41 type mesoporous silicon nanoparticles (CTAB@MSN) of active agent CTAB;

[0048] 2) Preparation of mercaptolated mesoporous silicon nanoparticles containing surfactant: Take 1.3g CTAB@MSN and disperse it in 108mL methanol, ultrasonically disperse it evenly, then add 1.3g 3-m...

Embodiment 2

[0055] The method similar to Example 1 was used to prepare mesoporous silicon nanoparticles with stimuli-response and intelligent drug-loading and drug-release characteristics in separate compartments, except that:

[0056] 6) Preparation of DOX-loaded reduction-responsive mesoporous silicon drug-controlled release system (DOX@MSN-SS-CD): 100 mg of MSN-SS-alkyne was dispersed in 5 mL of methanol and 5 mL of PBS buffer with a pH value of 7.0 under dark conditions After ultrasonically dispersing uniformly, 30 mg of doxorubicin hydrochloride (DOX·HCl) was added, and the reaction mixture was vigorously stirred at room temperature for 24 h. Then add 50mg mono-6-azido-β-CD, 50mg CuSO 4 ·5H 2 O and 75 mg of sodium ascorbate were reacted at room temperature for 3 days under the protection of a nitrogen atmosphere, centrifuged and washed several times with secondary water and methanol, and vacuum-dried to obtain a reduction-responsive mesoporous plugged with cyclodextrin loaded with d...

Embodiment 3

[0059] Preparation of mesoporous silicon nanoparticles with stimuli-responsive and intelligent drug-loading and drug-releasing properties, the steps are as follows:

[0060] 1) Preparation of mesoporous silicon nanoparticles: Dissolve 0.2gCTAB and 0.014gNaOH in 480mL deionized water and stir vigorously, then heat to 80°C, stir evenly to obtain a mixed solution, then slowly add 1.6gTEOS dropwise to the above solution, The dropping speed is 15d / min, and the reaction is carried out under vigorous stirring at 70°C for 2 hours, centrifuged to obtain a white solid, which is washed several times with secondary water and methanol, and vacuum-dried to obtain the MCM-41 type with surfactant CTAB Mesoporous silicon nanoparticles (CTAB@MSN);

[0061]2) Preparation of mercaptolated mesoporous silicon nanoparticles containing surfactant (MSN-SH): Take 1.3g CTAB@MSN and disperse it in 108mL methanol, ultrasonically disperse it evenly, then add 2.6g 3-mercaptopropyltrimethyl Oxysilane was vi...

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Abstract

The invention relates to mesoporous silicon nano particles having the properties of stimulation response and split-warehouse intelligent drug carrying and release and a preparation method of the mesoporous silicon nano particles. The mesoporous silicon nano particles are characterized in that stimulation response groups are modified on the surface, cyclodextrin modified by alkynylation is used as a nano-valve for realizing split-warehouse medicine carrying, and the particle size is 80-190 nm. The mesoporous silicon nano particles provided by the invention have a carrier system which can store and transport two medicines on the same carrier in a split manner, namely, a split-warehouse double-medicine even multi-medicine co-carrying medicine delivery system, through the effects of the cyclodextrin nano-valve and the response of the stimulation response groups for different extracellular and intracellular stimulation environments, the targeted and intelligent medicine delivery for the tumor cells can be realized.

Description

technical field [0001] The technical field of nanomaterials of the present invention, in particular, relates to a mesoporous silicon nanoparticle with stimuli-responsive and compartmentalized intelligent drug loading and drug release characteristics and a preparation method thereof. Background technique [0002] As a nanomaterial with excellent physical and chemical properties, mesoporous silicon has great potential for drug / gene delivery as a drug carrier in biomedicine. Mesoporous silicon nanoparticles have many excellent properties, such as simple synthesis method, high specific surface area, large pore volume, easy surface modification, easy adjustment of nanoparticle size and mesoporous diameter, and stable properties. However, traditional mesoporous silicon is non-specific and can release drugs not only in lesion tissues but also in normal tissues, greatly reducing the drug efficacy. Therefore, functionalized mesoporous silicon emerges accordingly. [0003] Functiona...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/04A61K47/40A61K31/704A61K31/52A61P35/00
Inventor 吕波胡英黄琳
Owner WUHAN UNIV OF TECH
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