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A kind of veterinary traditional Chinese medicine immunopotentiator and application thereof

An immune enhancer and traditional Chinese medicine technology, applied in veterinary vaccines, vaccines, antiviral agents, etc., can solve the problems of rising breeding costs, physiological metabolism restrictions, loss, etc., to restore the body's normal immunity, improve vaccine quality, improve effect of immunity

Active Publication Date: 2020-05-01
商丘美兰生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Immunosuppression restricts the physiological metabolism of livestock and poultry, affects growth and development, and raises the cost of breeding significantly; on the other hand, the immune system is damaged, organs, tissues and cells participating in the immune response are destroyed, and the presentation of antigens is interfered. The formation of antibodies is inhibited or blocked, and the barrier protection function of the body is weakened or lost, resulting in secondary or concurrent diseases of livestock and poultry, and can also lead to a decline in the ability of livestock and poultry to respond to vaccine immunity, often failing to achieve effective immune level of protection, resulting in failure of immune protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: A traditional Chinese medicine immunopotentiator for veterinary use is characterized in that it is prepared from the following raw materials in parts by weight: 10 grams of angelica polysaccharide, 6 grams of lentinan, 4 grams of aloe polysaccharide, hydrogenated polyoxyethylene 20 grams of castor oil, 10 grams of absolute ethanol, 30 grams of ethyl acetate, and 20 grams of water for injection.

[0016] Under sterile conditions, first mix 20 grams of polyoxyethylene hydrogenated castor oil and 10 grams of absolute ethanol, then add 30 grams of ethyl acetate, mix well, and obtain a mixed solution 1, take 10 grams of angelica polysaccharide, 6 grams of mushroom Polysaccharide, 4 grams of aloe polysaccharide and 20 grams of water for injection were mixed evenly to obtain a mixed solution 2, and the mixed solution 2 was added to the mixed solution 1, and the stirring was continued during the addition process, and the stirring was continued for 15 minutes until ...

Embodiment 2

[0017] Example 2: Screening of Angelica polysaccharide, Lentinan, and Aloe Polysaccharide Optimal Ratio

[0018] (1) Grouping and disposal

[0019] 3-factor 3-level orthogonal design L9 (3 4 ) grouping, each polysaccharide was taken as a factor, and different concentrations were taken as level items. The results of the orthogonal design grouping are shown in Table 1. Kunming mice weighing 18-22 g were randomly divided into 11 groups, 10 mice in each group, and labeled with picric acid. Among them, groups 1-9 are polysaccharide groups with orthogonal design: the corresponding polysaccharide prescriptions of traditional Chinese medicine in each group are administered by intragastric administration; normal control group and cyclophosphamide control group: normal saline is administered intragastrically. The intragastric volume of mice in each group was 0.2 ml, and the drug was administered once a day for 14 consecutive days. Except for the normal control group, mice in other gr...

Embodiment 3

[0051] Example 3: Antibody effect of traditional Chinese medicine enhancer on chicken Newcastle disease vaccine (La Sota strain)

[0052] 50 7-day-old AA white-feathered broilers were randomly and equally divided into ① normal saline group, ② Newcastle disease inactivated antigen group, ③ traditional Chinese medicine enhancer group, ④ traditional Chinese medicine enhancer + inactivated antigen group, ⑤ commercially available Newcastle disease inactivated vaccine ( La Sota strain) group was immunized twice at the age of 7 days and 14 days by chest intramuscular injection, respectively, at 14, 21, 28, and 35 days after immunization, the blood was collected to separate the serum, and the content of the corresponding Newcastle disease antibody was detected by the HI method. The test results are shown in Table 3.

[0053] Table 3 Antibody detection results of chicken Newcastle disease vaccine (La Sota strain)

[0054] group 14 days 21 days 28 days 35 days sa...

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Abstract

The invention belongs to the field of veterinary use medicine, and particularly relates to a veterinary use traditional Chinese immunopotentiator and application thereof. the veterinary use traditional Chinese immunopotentiator is prepared from the following raw materials in parts by weight: 7 to 14 parts of radix angelicae sinensis polysaccharide, 2 to 10 parts of mushroom polysaccharide, 3 to 8 parts of aloe polysaccharide, 10 to 30 parts of polyoxyethylene hydrogenated castor oil, 5 to 15 parts of absolute ethyl alcohol, 20 to 40 parts of ethyl acetate and 10 to 30 parts of water for injection. The veterinary use traditional Chinese immunopotentiator is applied to Newcastle disease inactivated vaccines (La Sota strains); the self immunopotentiation effect of the traditional Chinese medicine is achieved; the defects of conventional adjuvants can be avoided; the immune effect is obviously improved; safety, high efficiency and non-toxicity are realized; meanwhile, the veterinary use traditional Chinese immunopotentiator is prepared into nanoemulsion; the antigen slow release is realized; the immunization period of the vaccine is prolonged; and the vaccine quality is greatly improved.

Description

technical field [0001] The invention belongs to the field of veterinary medicines, in particular to a veterinary vaccine immune enhancer and its application. Background technique [0002] Immunosuppression in livestock and poultry is a common clinical pathological phenomenon, which is seriously harmful to the breeding industry. There are many reasons for poultry immunosuppression, including mycotoxin contamination in feed, irregular use of drugs, especially those containing immunosuppressive ingredients, improper long-term feeding management, environmental stress, etc. Immunosuppression restricts the physiological metabolism of livestock and poultry, affects growth and development, and raises the cost of breeding significantly; on the other hand, the immune system is damaged, organs, tissues and cells participating in the immune response are destroyed, and the presentation of antigens is interfered. The formation of antibodies is inhibited or blocked, and the barrier protec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K9/107A61K47/44A61K39/17A61P31/14
CPCA61K9/1075A61K39/12A61K39/39A61K47/44A61K2039/5252A61K2039/552A61K2039/55566A61K2039/55583C12N2760/18134
Inventor 李自波姬星宇王彦辉乔云龙焦金英姚奋卯胡玉胜郭平霞
Owner 商丘美兰生物工程有限公司
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