Preparation with new efficacies of activating blood circulation and removing blood stasis and preparation method thereof

Abstract

The invention discloses a preparation with the new efficacies of activating blood circulation and removing blood stasis and a preparation method thereof. The preparation comprises the following components in parts by weight: 250-350 parts of motherwort, 150-250 parts of angelica sinensis, 100-200 parts of ligusticum wallichii, 80-120 parts of sodium alginate, 25-35 parts of hydroxy propyl methyl cellulose, 145-270 parts of glucan, 30-70 parts of calcium hydrophosphate, 50-70 parts of sodium carboxymethyl starch, 10-30 parts of lauryl sodium sulfate and 3-5 parts of micro-powder silica gel. The preparation is prepared into a dispersing tablet, and the preparation method comprises the following steps: extracting and preparing a medicinal material into dry paste powder, preparing the dry paste powder into an inclusion compound and then further preparing the inclusion compound into the dispersing tablet. In the preparation disclosed by the invention, the solubility of an insoluble drug in the dry paste powder extracted from the medicinal material can be significantly improved, the disintegration time is shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost, low in energy consumption and easy to realize industrial production.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a medicine and a preparation method thereof, in particular to a preparation with the effects of promoting blood circulation, expelling blood stasis and promoting new life, and a preparation method thereof. Background technique [0002] Postpartum congestion after childbirth is mainly leftover blood and turbid fluid in the uterus, which is caused by abnormal circulation of Qi and blood, blood stasis and Qi stagnation, and is one of the common clinical diseases in obstetrics and gynecology. Western medicine believes that the cause is mainly incomplete uterine recovery, when part of the placenta, fetal membranes remain or infection affects uterine contraction and recovery; Local factors such as swelling and uterine fibroids can affect incomplete uterine recovery; secondly, after cesarean section, the incision of the uterine wall is dehiscated, the hemostasis during the operation is not comple...

AI Technical Summary

Problems solved by technology

[0006] The extraction process of raw medicinal materials is as follows: Angelica sinensis is percolated with ethanol to make a clear ointment, the dregs and motherwort are decocted with water, concentrated to make a clear ointment, Chuanxiong is directly crushed into fine powder without extraction, and the extraction method of Angelica sinensis is time-consuming and effective. The component transfer rate is low and there are many impurities in the extract due to the absence of any impurity removal process

The extraction process of the patent "A Preparation Method for Cihang Tablets" (Application No. 201510011473.6) is as follows: Ligusticum chuanxiong is crushed into fine powder, the surface is wetted with ethanol, sealed for a certain period of time, dried at a certain temperature for a certain period of time, and then directly Used as medicine, Angelica is extracted with alcohol and then concentrated into a clear ointment for medicine. The dregs of Angelica after alcohol extraction are extracted with motherwort and then concentrated into a clear ointment for medicine. Although the extraction time of Angelica is shortened, it still does not go through any steps of removing impurities

None of the above extraction methods can meet the requirement that the impurities in the extract of traditional Chinese medicine should be as little as possible during the preparation of dispersible tablets, so as to ensure the content of active ingredients in the preparation and the requirements of drug efficacy.

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