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Application of gigantol and gigantol composition to preparation of drugs for preventing and treating atherosclerosis

A technology of atherosclerosis and dendrobium, which is applied in the field of application of dendrobin in the preparation of drugs for the prevention and treatment of atherosclerosis, and can solve the problems of no medicines for the prevention and treatment of atherosclerosis of dendrobium, and achieve the goal clear effect

Active Publication Date: 2017-11-03
HEFEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there has been no relevant report on the use of dendrobium as a drug for the prevention and treatment of atherosclerosis

Method used

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  • Application of gigantol and gigantol composition to preparation of drugs for preventing and treating atherosclerosis
  • Application of gigantol and gigantol composition to preparation of drugs for preventing and treating atherosclerosis
  • Application of gigantol and gigantol composition to preparation of drugs for preventing and treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Effect of dendrobium on blood lipid and aortic plaque formation in atherosclerosis model mice.

[0022] 1. Experimental animal: ApoE - / - Mice, 5-7 weeks, male.

[0023] 2, drug preparation: select the tablet that is used for the prevention or treatment of atherosclerosis that the content of dendrobium phenol is 25mg / sheet (except that dendrobium phenol, all the other ingredients are the routine adjuvant of preparation tablet, as starch, powdered sugar, lactose, dextrin, maltodextrin and compressible starch), ultrasonically dispersed in 0.5% sodium carboxymethylcellulose (CMC-Na), for oral administration, the dosage is 25mg / kg.

[0024] 3. Experimental equipment: high-speed refrigerated centrifuge, ABI Step one fluorescence quantitative PCR instrument, cryostat, microplate reader, optical microscope, etc.

[0025] experimental method:

[0026] (1) Grouping and treatment: After adapting to the environment for 1 week, the animals were randomly divided into c...

Embodiment 2

[0037] According to the conventional preparation method, dendrobium was dissolved by adding water and an appropriate amount of solubilizer (polyethylene glycol 400), subpackaged, and sterilized to prepare an oral liquid for the prevention or treatment of atherosclerosis with a content of dendrobium of 25 mg / mL;

[0038] Dendrobium is prepared according to the conventional preparation method, gelatin and sorbitol are selected as the soft capsule material, and a capsule for the prevention or treatment of atherosclerosis with a content of dendrobium of 25 mg / capsule is prepared;

[0039] According to the conventional preparation method, dendrobium was added with excipient cyclodextrin, mixed uniformly, granulated, and compressed into tablets to prepare tablets for prevention and treatment of atherosclerosis with a content of dendrobium of 25 mg / tablet.

Embodiment 3

[0040] Example 3: Safety evaluation of Dendrobium phenol.

[0041] The acute toxicity test in mice adopts a single oral fixed dose method: four fixed doses of 5, 50, 500 and 2000 mg / kg are selected, and each dose is 10 Kunming mice, 5-7 weeks, half male and half male. Mice were fasted for 12 hours before administration and without water. In the experiment, the mice were administered by intragastric administration, and observed continuously for 2 weeks after administration. As a result, it was found that no mice died in each dose group of Dendrobium, except that some mice in the high-dose group (2000mg / kg) had a slight toxic reaction within 24 hours, and no toxic symptoms were found in the mice of the other dose groups, indicating that Dendrobium Phenol has less toxicity and higher safety.

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Abstract

The invention belongs to novel medicine applications of active component gigantol of traditional Chinese medicinal materials, and particularly relates to an application of the gigantol to preparation of drugs for preventing and treating atherosclerosis. Animal test results show that the gigantol has obvious preventing and improving effects on mouse aortic atherosclerotic plaques of an atherosclerosis model. Health care products or drugs for preventing and treating the atherosclerosis can be prepared from the gigantol and relevant accessories by a conventional preparation method.

Description

technical field [0001] The invention belongs to the new medical application of dendrobium phenol, an active ingredient of traditional Chinese medicinal materials, and specifically relates to the application of dendrobium phenol in the preparation of drugs for preventing and treating atherosclerosis. Background technique [0002] Atherosclerotic cardiovascular disease is one of the most common causes of death in the world. In China, the number of deaths induced by cardiovascular diseases accounts for about 1 / 3 of all deaths, and its incidence and mortality are increasing year by year. The pathogenesis of atherosclerosis is complex, with many causes, and its formation is a complicated process. Epidemiological data suggest that the level of serum low-density lipoprotein cholesterol is positively correlated with the occurrence of atherosclerosis, while the cholesterol in high-density lipoprotein transports cholesterol reversely to the liver for processing, which can reduce the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P9/10A61P3/06
CPCA61K31/09
Inventor 王伟王倩倩吴燕王儒情徐忠东
Owner HEFEI NORMAL UNIV
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