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Modified gold nanorod @ gadolinium oxysulfide (Gd2O2S) and preparation method thereof

A gold nanorod, modified technology, applied in nanotechnology, nanotechnology, metal processing equipment and other directions, can solve the problems of easy thermal deformation, cytotoxicity, reduced aspect ratio, etc., to improve photothermal stability, The effect of reducing biological toxicity and simple preparation method

Inactive Publication Date: 2017-10-13
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But CTAB is a biotoxic molecule that has toxic effects on cells
In addition, gold nanorods are prone to thermal deformation under laser irradiation, and the gold nanorods gradually transform from a rod-like structure to a spherical structure, and the aspect ratio is significantly reduced, resulting in an obvious blue shift of LSPR.
This thermal deformation greatly limits the application of gold nanorods at high temperature, and is also unfavorable for the photothermal therapy of gold nanorods in biomedicine.

Method used

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  • Modified gold nanorod @ gadolinium oxysulfide (Gd2O2S) and preparation method thereof
  • Modified gold nanorod @ gadolinium oxysulfide (Gd2O2S) and preparation method thereof
  • Modified gold nanorod @ gadolinium oxysulfide (Gd2O2S) and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of modified GNRs@Gd with a shell thickness of 4 nm 2 o 2 S, including the following steps:

[0032] 1) Preparation of seed crystal solution: mix 0.01 M, 0.25 mL HAuCl 4 Add to the 0.1 M, 9.75 mL CTAB solution and stir with freshly prepared ice-cold 0.01 M, 0.6 mL NaBH 4 The solution was added to the mixture solution, stirring was continued for 2 minutes, and then it was left to stand at room temperature for 2 h;

[0033] 2) Preparation of growth solution: mix 0.01 M, 2 mL HAuCl 4 with 0.01 M, 0.35 mL AgNO 3 Incubate with 0.1 M, 40 mL CTAB solution, then add 0.1 M, 0.32 mL AA;

[0034] 3) Preparation of gold nanorods: Inject 25 μL of the seed solution into the growth solution, mix the solution gently for 30 seconds, and let stand at 28 °C for 6 hours to obtain the desired GNRs;

[0035] 4) Preparation of modified GNRs@Gd 2 o 2 S: Mix 10 mL of uncentrifuged GNRs prepared in step 3) with 1 mL, 0.1 M hexamethylenetetramine, 0.5 mL, 0.1 M AA and 40 μL, 0....

Embodiment 2

[0037] Preparation of modified GNRs@Gd with 8 nm thick shell 2 o 2 S, including the following steps:

[0038] 1) Preparation of seed crystal solution: mix 0.01 M, 0.25 mL HAuCl 4 Add to the 0.1 M, 9.75 mL CTAB solution and stir with freshly prepared ice-cold 0.01 M, 0.6 mL NaBH 4 The solution was added to the mixture solution, stirring was continued for 2 minutes, and then it was left to stand at room temperature for 2 h;

[0039] 2) Preparation of growth solution: mix 0.01 M, 2 mL HAuCl 4 with 0.01 M, 0.35 mL AgNO 3 Incubate with 0.1 M, 40 mL CTAB solution, then add 0.1 M, 0.32 mL AA;

[0040] 3) Preparation of gold nanorods: Inject 25 μL of the seed solution into the growth solution, mix the solution gently for 30 seconds, and let stand at 30 °C for 6 hours to obtain the desired GNRs;

[0041] 4) Preparation of modified GNRs@Gd 2 o 2 S: Mix 10 mL of uncentrifuged GNRs prepared in step 3) with 1 mL, 0.1 M hexamethylenetetramine, 0.5 mL, 0.1 M AA and 40 μL, 0.5 M thioa...

Embodiment 3

[0043] Preparation of modified GNRs@Gd with 20 nm thick shell 2 o 2 S, including the following steps:

[0044] 1) Preparation of seed crystal solution: mix 0.01 M, 0.25 mL HAuCl 4 Add to the 0.1 M, 9.75 mL CTAB solution and stir with freshly prepared ice-cold 0.01 M, 0.6 mL NaBH 4 The solution was added to the mixture solution, stirring was continued for 2 minutes, and then it was left to stand at room temperature for 2 h;

[0045] 2) Preparation of growth solution: mix 0.01 M, 2 mL HAuCl 4 with 0.01 M, 0.35 mL AgNO 3 Incubate with 0.1 M, 40 mL CTAB solution, then add 0.1 M, 0.32 mL AA;

[0046] 3) Preparation of gold nanorods: Inject 25 μL of the seed solution into the growth solution, mix the solution gently for 30 seconds, and let stand at 30 °C for 6 hours to obtain the desired GNRs;

[0047] 4) Preparation of modified GNRs@Gd 2 o 2 S: Mix 10 mL of uncentrifuged GNRs prepared in step 3) with 1 mL, 0.1 M hexamethylenetetramine, 0.5 mL, 0.1 M AA and 40 μL, 0.8 M thio...

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Abstract

The invention relates to a preparation method of a gadolinium oxysulfide (Gd2O2S) gold nanorod core-shell structure. The preparation method comprises the following steps: preparing seed crystals, preparing a growth solution, preparing gold nanorods and preparing the Gd2O2S gold nanorod core-shell structure (GNRs@Gd2O2S). The modified gold nanorod @ gadolinium oxysulfide (Gd2O2S) and the preparation method thereof have the characteristics as follows: the preparation method is simple and repeatable, the biocompatibility is good, and good light-heat conversion efficiency is achieved; besides, both magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) can be carried out, the diagnosis and treatment of tumor are combined, and good biological-medical and cancer therapic application prospects are achieved.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation, and specifically relates to a modified gold nanorod@gadolinium oxysulfide and a preparation method thereof. Background technique [0002] In the past two decades, nanomaterials have been extensively explored for biological applications due to their unique optical and physical properties, especially in bioimaging and drug delivery. Gold nanorods are one of the most studied colloidal nanoparticles. As a typical plasmonic nanoparticle, gold nanorods can adjust its longitudinal surface plasmon resonance properties in the near-infrared region, and have been widely used in the field of disease diagnosis. explore. Most gold-based nanoplatforms use plasmon resonance to enhance two-photon photoluminescence and localized photothermal, while improving bioimaging and photothermal therapy. Monodisperse gold nanorods are usually prepared by seed crystal method, using cationic surfactant CTAB as "soft ...

Claims

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Application Information

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IPC IPC(8): B22F1/02A61K41/00A61K49/08A61K49/22B82Y30/00B82Y40/00
CPCA61K41/0052A61K49/08A61K49/225B82Y30/00B82Y40/00B22F1/16
Inventor 杨黄浩林艳郭涛黄国明吴颖欧翔宇
Owner FUZHOU UNIV
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