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Carbon monoxide releasing molecule with up-conversion nano-phosphor, method for preparing carbon monoxide releasing molecule and application thereof

A luminescent material, carbon monoxide technology, applied in luminescent materials, chemical instruments and methods, wave energy or particle radiation treatment materials, etc., can solve the problem of difficult to induce PhotoCORMs to release CO, achieve good up-conversion luminescence characteristics, broad application prospects, Simple steps to synthesize effects

Inactive Publication Date: 2017-09-22
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention aims to solve the technical problem that long-wavelength (near-infrared) light is difficult to induce PhotoCORMs to release CO

Method used

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  • Carbon monoxide releasing molecule with up-conversion nano-phosphor, method for preparing carbon monoxide releasing molecule and application thereof
  • Carbon monoxide releasing molecule with up-conversion nano-phosphor, method for preparing carbon monoxide releasing molecule and application thereof
  • Carbon monoxide releasing molecule with up-conversion nano-phosphor, method for preparing carbon monoxide releasing molecule and application thereof

Examples

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Embodiment 1

[0035] 1. A preparation method of an up-conversion luminescent material carbon monoxide release agent

[0036] (1) Preparation of UCNPs nanomaterials

[0037] At room temperature, take the precursor (LnCl 3 , Ln 3+ =Y 3+ , Yb 3+ , Er 3+ ; molar ratio Y 3+ :Yb 3+ :Er 3+ =78:20:2) 2mL, 6mL of oleic acid, 15mL of 1-octadecene were added to a 100mL three-necked flask, stirred and mixed evenly, then the temperature was raised to 50°C and kept for 20min, then raised to 140°C and kept at this temperature 60min. After natural cooling to 30°C, 10mL methanol (dissolved with 2.5mmol NaOH, 4mmol NH 4 F) Add dropwise to the reaction solution, and after 10 minutes, raise the temperature to 70° C. to remove methanol. Finally, argon was passed and degassed at 100 °C for 10 min, then the temperature was rapidly raised to 320 °C and the reaction was carried out at this temperature for 60 min to generate upconversion nanoparticles UCNPs. After washing with ethanol, UCNPs were disperse...

Embodiment 2

[0047] 1. A preparation method of an up-conversion luminescent material carbon monoxide release agent

[0048] (1) Preparation of UCNPs nanomaterials

[0049] At room temperature, take the precursor (LnCl 3 , Ln 3+ =Y 3+ , Yb 3+ , Er 3+ ; molar ratio Y 3+ :Yb 3+ :Er 3+ =78:20:2) 2mL, oleic acid 10mL, 1-octadecene 20mL were added to a 100mL three-necked flask, stirred and mixed evenly, then the temperature was raised to 50°C and kept for 20min, then raised to 140°C and kept at this temperature 60min. After natural cooling to 30°C, 10mL methanol (dissolved with 2.5mmol NaOH, 4mmol NH 4 F) Add dropwise to the reaction solution, and after 10 minutes, raise the temperature to 70° C. to remove methanol. Finally, argon was passed and degassed at 100 °C for 10 min, then the temperature was rapidly raised to 300 °C and the reaction was carried out at this temperature for 90 min to generate upconversion nanoparticles UCNPs. UCNPs were washed with ethanol and dispersed in cycl...

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Abstract

The invention discloses a carbon monoxide releasing molecule with up-conversion nano-phosphor, a method for preparing the carbon monoxide releasing molecule and application of the carbon monoxide releasing molecule as a CO carrier medicine. The method includes synthesizing the up-conversion nano-phosphor from aqueous solution of Y, Yb and Er chloride, organic solvents and methanol solution with sodium hydroxide and ammonium fluoride; uniformly stirring surfactants, cyclohexane and cyclohexane dispersion liquid with the up-conversion nano-phosphor to obtain first mixtures, then adding ammonia water into the first mixtures to obtain second mixtures, sealing the second mixtures and then ultrasonically dispersing the second mixtures in ice bath; adding tetraethyl orthosilicate into mixtures and carrying out reaction; adding silane coupling agents with thiol into mixtures and carrying out reaction; adding dichloromethane solution with iron carbonyl compounds into mixtures, carrying out reaction and centrifuging and washing reaction products to obtain the carbon monoxide releasing molecule with the up-conversion nano-phosphor. The carbon monoxide releasing molecule, the method and the application have the advantages that the UCNPs@SiO2-CORM (up-conversion nano-phosphor@SiO2-carbon monoxide releasing molecule) is excellent in up-conversion luminescence characteristics, and CO can be released under the induction effect of near-infrared light.

Description

technical field [0001] The invention belongs to the technical field of carbon monoxide releasing agents, and in particular relates to a carbon monoxide releasing agent based on an up-conversion luminescent material, a preparation method thereof, and an application thereof in carrying carbon monoxide. Background technique [0002] Carbon monoxide (CO) is well known to the public as a toxic gas, but recent studies have found that CO is an important messenger molecule in the human body, which can assist nitric oxide (NO) to regulate the functions of internal organs in the human body. Studies have shown that the endogenous CO produced by the degradation of heme catalyzed by heme oxygenase in the body has many physiological effects, such as reducing the degree of vasoconstriction during stress, thereby reducing blood pressure and increasing blood flow, and reducing myocardial ischemia and reperfusion. Damage to cardiac function, reduction of infarct size, suppression of immune re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85A61K41/00
CPCC09K11/7773A61K41/00
Inventor 刘小明肖志音郑伟华
Owner JIAXING UNIV
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