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Preparation method of through-hole dual-network polymeric hydrogel scaffold

A polymer, dual network technology, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve problems such as limited application, and achieve the effect of avoiding deformation

Active Publication Date: 2017-09-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these published techniques do not involve the preparation of hydrogels as scaffolds with three-dimensional through-pores, which limits the application of the hydrogels in soft tissue engineering.

Method used

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  • Preparation method of through-hole dual-network polymeric hydrogel scaffold

Examples

Experimental program
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Effect test

Embodiment 1

[0028] In step A) of the present invention, use fused deposition modeling (FDM) additive manufacturing printer and polylactic acid as consumables to manufacture such as figure 1 A polylactic acid porous scaffold template with a pore size of 500 microns and through holes;

[0029] Step B), 9.8 grams of water, 0.2 grams of sodium alginate and 0.01 grams of glutaraldehyde are mixed and poured into the porous template, and then placed in a low-temperature freeze dryer to dry to obtain the porous scaffold template / single network polymer preform SN ;

[0030] Step C), mix 1.0 g of water, 0.5 g of acrylamide monomer, 0.05 g of N,N-methylene-bisacrylamide crosslinker, 0.01 g of ammonium persulfate, and 0.01 g of tetramethylethylenediamine and perfuse Enter the porous scaffold template / single network polymer preform SN, and then place it in a nitrogen environment with a temperature of 50°C and a humidity of 90% for 12 hours to obtain the porous scaffold template / double network polymer...

Embodiment 2

[0033] ABS was used as the printing consumable, and other preparation conditions were the same as in Example 1 to obtain an alginic acid-polyacrylamide double network polymer hydrogel scaffold with a pore diameter of 500 microns and through pores.

Embodiment 3

[0035] In step A), a porous polylactic acid scaffold with a pore diameter of 10 microns was printed, and the other preparation conditions were the same as in Example 1 to obtain an alginic acid-polyacrylamide double network polymer hydrogel with a pore diameter of 10 microns and through pores stand.

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Abstract

The invention relates to a preparation method of a through-hole dual-network polymeric hydrogel scaffold, and belongs to the field of biomedical high-molecular materials. The method is characterized in that a porous scaffold manufactured by three-dimensional printing is taken as a template, and two-step polymer pouring and subsequent removal of the porous scaffold template are performed obtain the through-hole dual-network polymeric hydrogel scaffold. By adopting a preparation technology disclosed by the invention, technical limits caused by overlapping layer by layer and limits on the application of a hydrogel material in a three-dimensional printing manufacturing process can be broken effectively, and a through-hole dual-network polymeric hydrogel scaffold which is consistent with the porous scaffold template in structure, is molded at one time and has high mechanical property can be obtained.

Description

technical field [0001] The invention relates to a hydrogel preparation technology, in particular to a method for forming a double-network polymer hydrogel scaffold with good mechanical energy and through holes, and belongs to the field of biomedical polymer materials. Background technique [0002] Due to its good biocompatibility and insolubility under the condition of maintaining a large amount of water, hydrogel has always been regarded as the best material for soft tissue engineering repair. In practical applications, it is usually necessary to process the medical hydrogel into a scaffold that is consistent with the anatomical structure of the defect tissue. At the same time, the hydrogel scaffold should also have three-dimensional The interpenetrating pores allow cells and tissues to enter the hydrogel to grow and regenerate tissues, and the cells and tissues in the pores of the hydrogel scaffold can effectively carry out a series of physiological activities such as nutr...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/56A61L27/16A61L27/20A61L27/18A61L27/24C08F251/00C08F220/56C08F222/38
CPCA61L27/16A61L27/18A61L27/20A61L27/24A61L27/52A61L27/56A61L2430/06C08F251/00C08L5/04C08L5/08C08L29/04C08L89/00C08L33/26C08L67/04C08F220/56C08F222/385
Inventor 洪友良郭波
Owner SICHUAN UNIV
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