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Antimicrobial nano-particle preparation method using metal-organic framework as biocarrier for packing medicine

A metal-organic framework, antibacterial nanoparticle technology, applied in the field of nanomaterials, can solve the problems of poor thermal stability and chemical stability of antibacterial particles, inability to control drug release, poor biocompatibility, etc. Value-added, good adsorption effect

Active Publication Date: 2017-09-08
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing antibacterial nano-ions have low drug loading and cannot release drugs in a controlled manner. At the same time, antibacterial particles have poor thermal and chemical stability, high toxicity, and poor biocompatibility, which cannot meet people's needs for them.

Method used

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  • Antimicrobial nano-particle preparation method using metal-organic framework as biocarrier for packing medicine
  • Antimicrobial nano-particle preparation method using metal-organic framework as biocarrier for packing medicine
  • Antimicrobial nano-particle preparation method using metal-organic framework as biocarrier for packing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] S1. Dissolve 72.09mg of ferric chloride hexahydrate and 44.3mg of terephthalic acid in 40mL N,N-dimethylformamide respectively, and then magnetically stir for 30min at room temperature to dissolve the two precursors. Put it into the same polytetrafluoroethylene reactor lining, and stir it magnetically for 20 minutes, so that the two precursor solutions are fully mixed;

[0031] The volume of the polytetrafluoroethylene reactor is 100ml;

[0032] S2. Put the inner liner of the reaction kettle on the steel sleeve and place it in an oven, heat up to 150° C. at a rate of 2° C. per minute, then react at a constant temperature for 72 hours, and place the reaction kettle at the tuyere for two hours to cool it down;

[0033] S3. Centrifuge the material cooled in step S2 at 8000 rpm for 15 minutes, collect the precipitate, and then wash and filter the product with N,N-dimethylformamide solution, deionized water, and ethanol solution in sequence to obtain metal organic framework ...

Embodiment 2

[0037] S1. Dissolve 54mg of ferric chloride hexahydrate and 33.2mg of terephthalic acid in 30mL of N,N-dimethylformamide respectively, and then magnetically stir for 30min at room temperature to dissolve the two precursors. Put it into the same polytetrafluoroethylene reactor lining, and stir it magnetically for 20 minutes, so that the two precursor solutions are fully mixed;

[0038] The volume of the polytetrafluoroethylene reactor is 100ml;

[0039] S2. Put the inner liner of the reaction kettle on the steel sleeve and place it in an oven, raise the temperature to 160° C. at a rate of 1° C. per minute, then react at a constant temperature for 72 hours, and place the reaction kettle at the tuyere for 1 hour to cool it down;

[0040] S3. Centrifuge the material cooled in step S2 at 9000rpm for 12min, collect the precipitate, and then wash and filter the product with N,N-dimethylformamide solution, deionized water and ethanol solution successively to obtain metal organic Skel...

Embodiment 3

[0044] S1. Dissolve 27mg of ferric chloride hexahydrate and 16.6mg of terephthalic acid in 15mL of N,N-dimethylformamide respectively, and stir magnetically at room temperature for 30min to dissolve them to prepare two kinds of precursors. Put it into the same polytetrafluoroethylene reactor lining, and stir it magnetically for 20 minutes, so that the two precursor solutions are fully mixed;

[0045] The volume of the polytetrafluoroethylene reactor is 50ml;

[0046] S2. Put the inner liner of the reaction kettle on the steel sleeve and place it in an oven, heat up to 170° C. at a rate of 2° C. per minute, then react at a constant temperature for 48 hours, and place the reaction kettle at the tuyere for two hours to cool it down;

[0047] S3. Centrifuge the material cooled in step S2 at 10,000 rpm for 10 minutes, collect the precipitate, and then wash and filter the product with N,N-dimethylformamide solution, deionized water, and ethanol solution in sequence to obtain metal o...

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Abstract

An antimicrobial nano-particle preparation method using a metal-organic framework as a biocarrier for packing a medicine comprises the following steps: S1, correspondingly mixing ferric chloridehexahydrate andterephthalic acid with N, N-dimethylformamide,and arranging into an inner tank of a Teflon reaction kettle; S2, arranging the inner tank of the reaction kettle into an oven,increasing the temperature,and then cooling; S3, centrifuging the substance cooled in step 2,collecting the precipitate,then performing washing and suction filtration on the product,drying in vacuum,and grinding to obtain metal-organic framework nano-particles; S4, mixing the metal-organic framework nano-particles and vancomycin,dissolving the mixture in deionized water,and then absorbing and loading medicine; and S5, filtering the substance obtained in step S5,washing,performing suction filtration,and drying in vacuum to obtain the medicine-packed metal-organic frameworknano-particle composite. The method has the advantages of being capable of absorbing various different macromolecular and micromolecular medicines to form a double-functional metal-organic framework medicine loading system, and being simple in preparation process, green and environment-friendly.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a method for preparing antibacterial nanoparticles based on a metal-organic framework as a biological carrier to encapsulate medicines. Background technique [0002] The existing antibacterial nano-ions have low drug loading and cannot release drugs in a controlled manner. At the same time, antibacterial particles have poor thermal and chemical stability, high toxicity, and poor biocompatibility, which cannot meet people's needs for them. Contents of the invention [0003] In order to solve the above-mentioned technical defects, the present invention provides a method for preparing antibacterial nanoparticles based on metal organic framework as a biological carrier to encapsulate drugs, specifically encapsulating glycopeptides that are non-toxic and have strong antibacterial effects with iron-containing metal organic frameworks Antibiotic vancomycin, thus forming nanocomp...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K38/14A61K47/24A61P31/04B82Y40/00B82Y5/00B82Y30/00
CPCA61K9/5123A61K38/14B82Y5/00B82Y30/00B82Y40/00
Inventor 吴水林林沙刘想梅崔振铎杨贤金
Owner HUBEI UNIV
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